Motilium dosage form as a suspension for oral administration is used primarily to treat gastritis and esophagitis in children. However, adults can also apply the suspension, especially when taking the pill causes marked gag reflex.

Peculiarities of composition and actions of suspension motilium

Antiemetic drugs of the central action of the slurry produced motilium Belgian pharmaceutical company Janssen Pharmaceutica in bottles of 100 ml. 1 ml suspension contains 1 mg of active principle motilium Motilium - help with the vomiting and impaired motor activity of the stomach   - Domperidone. Auxiliaries in the slurry are microcrystalline cellulose, carmellose sodium, uncrystallized liquid sorbitol, methyl parahydroxybenzoate, propyl parahydroxybenzoate, sodium saccharinate, polysorbate, sodium hydroxide, purified water. The package is also a dosing syringe.

Accepted slurry before a meal, it is rapidly absorbed into the blood and in tissue, but does not accumulate in the body. Suspension is metabolized in the liver, and then output mainly in the faeces (two-thirds) and partially (third) in the urine.

When you receive a suspension Motilium into its active substance blocks dopamine receptors. As a result of suppressed nausea and vomiting, increased duration of peristaltic contraction of smooth muscles of the stomach and intestines, the tone of the lower esophageal sphincter, is accelerated gastric emptying.

Motilium hardly enters the central nervous system (CNS) as bad overcome the blood brain barrier. Therefore, he rarely gives side effects of the central nervous system, unlike other drugs of this series, for example, Cerucalum.

To appoint

The suspension motilium prescribed mainly for the treatment of children with gastrointestinal disease, accompanied by slow evacuation of food from the stomach, again flowing food mixed with the acidic gastric juice into the esophagus (reflux) and the development of inflammation in the wall of the esophagus. This disease is known as gastroesophageal reflux disease (GERD). GERD manifests a sense of fullness, loss of appetite, bloating, pain in the stomach, heartburn, acid regurgitation content. Children who suffer from GERD, lag in physical development. Application Motilium promotes more rapid advance of the food mass from the stomach into the duodenum and prevents a reverse flow into their esophagus.

Suitable suspension motilium as nausea and vomiting from any source other than caused by vestibular disorders (for example, motion sickness).

How to take

The suspension motilium take half an hour before a meal, because after eating the drug is poorly absorbed. Adults and children after 12 years and weighing more than 35 kg, administered at 10-20 ml (10-20 mg which corresponds to one to two tablets) suspension of three - four times per day (maximum daily dose of 80 mg).

Babies, including up to a year designate 0.25-0.5 mg Motilium (0.25-0.5 ml suspension) per 1 kg of body weight three to four times a day (maximum daily dose - 2.4 mg per 1 kg of weight, but not more than 80 mg ).

Dosing suspension using the supplied syringe. Before using the vial of suspension must be a good shake, and then remove the cover, enter the syringe into the vial, type suspension to the level corresponding to the weight of the child, remove the syringe from the vial filled, pour the contents into a spoon and give the child. After that, close the bottle and thoroughly rinse the syringe with water.

Contraindications and possible side effects

Admission motilium suspension is contraindicated in children and adults with hypersensitivity to its components, increase the blood levels of the pituitary hormone prolactin Prolactin - effect on the body is not fully known , Taking certain medications (ketoconazole, fluconazole Fluconazole - used with caution , Erythromycin, or other), gastrointestinal bleeding, mechanical bowel obstruction, violation of the integrity of the walls of the gastrointestinal tract, breast- Breastfeeding - a personal choice   feeding.

Precautions suspension motilium prescribed during pregnancy, disorders of the liver or kidneys.

Side effects when taking suspension motilium are relatively rare, and occur in the same way as the reception of other dosage forms of the drug.

Motilium slurry can be used to treat children of all ages as well as adults. It must appoint a physician with all the indications and contraindications for the appointment of the drug.

Galina Romanenko

Odeston used in the treatment of chronic pancreatitis. Acute pancreatitis Odeston not treated, since in that case the drugs for parenteral (injectable and infusion) administration, and at Odeston have such a dosage form.

Chronic pancreatitis - how it develops

Chronic pancreatitis, or inflammation of the pancreas - a common disease. It usually develops after acute pancreatitis, with systematic violations of diet, frequent use of fatty and spicy foods, alcohol. Chronic pancreatitis may also be co-morbidity other pathology of the gastrointestinal tract, such as cholecystitis, gallbladder dyskinesia, sphincter of Oddi dyskinesia.

A feature of the pancreas is that it is closely connected with the rest of the digestive organs - liver, biliary ways, gall bladder and intestines. Communication takes place by means of ducts through which the bile and pancreatic juice coming into the intestine. Duct, in which the pancreatic juice from the pancreas enters the duodenum, shortly before the confluence is connected to the common bile duct. These ducts, there is also a common sphincter - smooth muscle that can close the channels and adjust the pressure between them and the duodenum. This is called the sphincter of Oddi's sphincter.

If the sphincter of Oddi is not functioning properly, then talk about it dyskinesia. In this case, may develop stagnation of bile in the gall bladder, inflammation and its transition infections on the pancreas. It is also possible infection from entering the duodenum and pancreas in the development of chronic pancreatitis. But the main mechanism for the development of chronic pancreatitis is a violation of the separation of pancreatic juice, large concentration in the pancreas and its self-digestion of certain small areas during exacerbations of the disease. In remission in situ necrosis areas developing connective tissue, which gradually leads to a reduction of pancreatic function.

Symptoms of chronic pancreatitis

Symptoms of chronic pancreatitis are very diverse. The most common symptoms are pain in the upper abdomen and left upper quadrant, loss of appetite, nausea, vomiting, diarrhea, weight loss due to violations of the processes of digestion and absorption of food, metabolism Metabolism: The basis of life of all living things   (especially protein), vitamin deficiencies.

Complications of chronic pancreatitis are cysts, stones pancreas Diabetes and pancreas - the things you need to know Thrombosis her veins stenosis ducts. In a progressive course of chronic pancreatitis may develop diabetes because the affected cells in the pancreas that produce insulin The principles of action of insulin - the science of saving lives . Against the backdrop of long flowing chronic pancreatitis may develop pancreatic cancer Pancreatic cancer - diagnosis of the problem .

Action Odeston in chronic pancreatitis

The main action is Odeston excretion of bile from the biliary tract. This is important for pancreatitis as bile stasis can always lead to the inflammatory process, which in turn can move on the pancreas.

But Odeston and has another important effect - it selectively removes the spasm of the sphincter of Oddi. This means that regulation of the pressure is restored between the common bile duct, pancreatic duct and ampulla, which fall into both of these flow.

As a result of the pancreatic ducts freely allocated by the pancreatic juice, that is, self-digestion process warned her tissue. This results in pain relief, the disappearance of bloating, stool recovery, improvement in laboratory parameters of pancreatic function.

Odeston well tolerated by patients with chronic pancreatitis and almost no side effects. It is given two tablets (400 mg) three times a day, half an hour before a meal. This provides a sufficient concentration of drug in blood during day. Duration of treatment - from one to three weeks. When a moderate course of chronic pancreatitis Odeston administered as monotherapy (one drug that), but more often it is still administered in the complex treatment.

Contraindications Odeston and its side effects

Contraindications Odeston are obstruction of the biliary tract, severe liver disease and kidney with a violation of their functions, erosive and ulcerative diseases of the stomach and intestines, bleeding disorders, age 18 years, drug idiosyncrasy.

Side effects manifested Odeston diarrhea, bloating, abdominal pain, erosive and ulcerative processes in the walls of the stomach and intestines, headache. Sometimes develop allergic reactions to Odeston.

Odeston able to significantly improve the condition of patients with chronic pancreatitis.

Galina Romanenko