- Ulcerative colitis: Complications after treatment
- Treatment
- Side effects of the treatment
Treatment
For the treatment of ulcerative colitis used medicines and surgical techniques. The latter is usually used in acute inflammation and life-threatening complications.
Exacerbations in patients with ulcerative colitis are followed by periods of remission, which lasts from several months to several years. During exacerbations enhanced abdominal pain, bleeding and diarrhea. Remission usually occurs after the treatment, but sometimes it happens spontaneously.
Ulcerative colitis can not be completely cured with medicines.
The objectives of medical treatment:
- Calling remission
- Save remission
- To minimize side effects of treatment
- To improve the quality of life
- To reduce the risk of cancer
During treatment using anti-inflammatory drugs and immunomodulators
Immunomodulators: a contract with the protective forces of the body
. Among the anti-inflammatory medications are used most frequently:
- Point 5-ASA compounds such as sulfasalazine, olsalazine and mesalamine that nabolee effective in direct contact with tissue inflammation
- Systemic anti-inflammatory drugs, such as corticosteroids can reduce inflammation without direct contact with affected areas
Immunomodulators - a medication that suppresses the immune system
The immune system - how it works?
body by reducing the amount of immune cells or inhibiting production of proteins involved in inflammatory processes. These drugs are often used in acute forms of ulcerative colitis when the patient does not help other medicines.
5-ASA compounds
The chemical composition of 5-aminosalicylic acid is similar to aspirin. However, acetylsalicylic acid, which, for many years is used in medicine, is not suitable for the treatment of ulcerative colitis. Compounds 5-aminosalicylic acid, in contrast, can be very effective in treating the disease if applied dot, i.e. directly on the affected areas.
Azulfidine
Sulfasalazine (Azulfidine) for many years been successfully used to induce remission in patients with mild to moderate forms of ulcerative colitis. Call remission means to reduce intestinal inflammation and relieving the symptoms of the disease. Sulfasalazine is also used in long-term therapy for preservation of remission.
The efficiency depends on the dosage of sulfasalazine - in particular, to induce remission, requires a fairly large dose. In some patients, larger doses cause severe diarrhea. Sometimes this effect is not so much if you take drugs with food; enteric capsule is also usually does not cause stomach upset.
Asacol
Tablets consist of Asacol mesalamine and acrylic shell. The shell does not allow 5-aminosalicylic acid to dissolve before it reaches the small intestine. When the tablet reaches the ileum and colon, the shell dissolves and 5-ASA into the intestine.
Asacol cause remission in patients with mild or moderate symptoms of ulcerative colitis. It is also used for maintenance of remission. The recommended dose for induction of remission Asacol - 2 tablets at 400 mg three times a day. For maintenance of remission should be taken on the same two tablets twice daily. In some cases, the recommended dose may be higher.
Among the other 5-ASA compounds used in the treatment of ulcerative colitis:
Lialda, Apriso, Pentasa and other drugs.
The side effects of 5-ASA compounds
In general, it is quite safe medicines, but they should avoid those who are allergic to aspirin.
In rare cases, these drugs can cause inflammation of the kidneys
Inflammation of the kidney - do not suffer pain
; patients who already have kidney disease, you need to take these medications with extreme care. Before treatment, it is recommended to check the function of the kidneys.
There are cases where these drugs cause side effects such as very severe diarrhea, cramping and abdominal pain
Abdominal pain: Types and Symptoms
, Fever, skin rashes and severe weakness. It is believed that this reaction is caused by an allergy to 5-ASA compounds.
Systemic corticosteroids
If corticosteroid treatment does not require direct contact with the affected tissue medications. Oral corticosteroids have effective anti-inflammatory action. In critical cases, corticosteroids may be administered intravenously.
They are faster than 5-ASA compounds. Most patients feel relief within a few days after the start of treatment, but corticosteroids are not suitable for the maintenance of remission.