Indinol - drug or another fiction?

September 24, 2009

   Indinol - a drug recently developed by a team of the Research Institute of Molecular Medicine (at the Moscow Medical Academy. Sechenov), together with scientists working at the Russian Research Center of Molecular Diagnostics and Therapy. This drug has not yet managed to enter the list of drugs registered in the official register of medicines of the Russian Federation. The active substance is indole-3-carbinol, was first isolated from broccoli (cruciferous plant).

 Indinol - drug or another fiction?

Brief general description of the

Indinol - herbal remedies, has anti-estrogenic and anti-tumor effect. It has a normalizing effect on the synthesis and metabolism of estrogen - one of the main hormones that regulate the activity of the female organism.

By normalizing the content of estrogen in the blood, Indinol has a positive effect on disorders resulting from increased concentration of these hormones in the blood (hyperestrogenemia).

Accordingly, Indinol can be used to treat any disease caused by an imbalance of estrogen, ie, with the broadest spectrum of diseases of the female sphere.

 Indinol - drug or another fiction?

Action Indinol

The basis of the action Indinol - normalization of estrogen metabolism, prevents the emergence and development of estrogen-dependent disease.

The drug promotes proper metabolism of estradiol and inhibits the formation of 16-hydroxyestrone that distinct known carcinogenic properties. Indinol reduces the amount of estrogen receptor Estrogen - the key to bone health  Estrogen - the key to bone health
   Depending on the hormone target tissues. Displaying its beneficial effect when hyperestrogenemia and caused its various functional disorders. Indinol inhibits the development of hyperplastic processes caused by dysregulation of cell division in tissues of the female reproductive system.

Indinol recommended women in epithelial tumors, hyperplastic processes affecting reproductive organs, estrogen-dependent tumors (including benign tumors and breast cancer, and internal reproductive organs). This drug helps selective apoptosis of tumor cells, neutralizes the effect of growth factors that promote the emergence and development of breast tumors.

Furthermore, Indinol epithelial cells blocked synthesis Cancer E7 protein produced in an organism infected by human papillomavirus. Accordingly, this drug may help prevent malignancy of papillomas.

 Indinol - drug or another fiction?

Product form

Indinol release capsule (a single package contains 30, 60 or 120 units). One capsule preparation contains 100 mg of active substance - indole-3-carbinol.

 Indinol - drug or another fiction?

In which case, it recommended the use of Indinol

The drug is used in the composition of traditional complex therapy of diseases of the female reproductive sphere, if they involve a violation of hormonal levels (namely, estrogen metabolism). In malignant diseases taking it combine with chemotherapy, radiotherapy or surgery (if indicated). In the pathology of a milder course and a better prognosis administered with immunomodulators and other essential drugs. With Indinol possible prevention of various disorders associated with hormonal imbalances, and hormone-dependent diseases, including cancer.

The main indications for use Indinol include breast cancer, dysplasia Dysplasia - what is it?  Dysplasia - what is it?
   and cervical cancer, ovarian cancer, endometriosis and associated disorders, adenomyosis, myoma / uterine fibroids, ovarian cysts Ovarian cysts - normal or dangerous?  Ovarian cysts - normal or dangerous?
 , Breast (cystic and fibrous), premenstrual syndrome, the effects of infection with the human papilloma virus (HPV), including traditional papilloma respiratory papillomatosis and genital warts.

 Indinol - drug or another fiction?

Dosing, dosing

Indinol taken orally during meals or before a dose of 400 mg (two capsules twice a day), every day for 3-6 months.

When uterine / uterine fibroids or endometriosis combined with the use of Indinol epigallatom (this drug is also not included in the list of drugs registered in the official register of medicines of the Russian Federation). Indinol should take two capsules twice a day for six months. To prevent a recurrence Indinol with epigallatom administered in the same dose, the course of three months.

In order to treat cystic fibrosis and mastopathy Indinol used dose two capsules twice a day for six months, for preventing - in the same dosage and under the same conditions, the course of three months.

When infected with human papillomavirus (regardless of form) Indinol should take two capsules twice a day for six months during treatment with immunomodulatory and / or anti-viral drugs (prescribed by a doctor).

Contraindications to the use of the drug include individual intolerance Indinol or components of the drug (immediate hypersensitivity reactions or delayed type). The drug is not recommended in combination with drugs that reduce gastric acidity.

Side effects include a variety of individual reactions to the reception Indinol.

 Indinol - drug or another fiction?

Safety measures

You should not start taking this drug without first consulting your doctor. The drug should be kept out of reach of children and pets.

 Indinol - drug or another fiction?

Storage conditions

Capsules were stored at room temperature in a dry place. Shelf life is two years.

 Indinol - drug or another fiction?

Who should take Indinol

Official Indinol area of ​​application is as follows (from the site of Rospotrebnadzor) for sale to the public through specialized shops and pharmacies network of Retail Network as a dietary food supplement - a source of indole-3-carbinol.

The instructions included with the drug, these statements are considerably expanded:

  • mastitis;
  • mammary cancer Breast cancer: what every woman needs to know  Breast cancer: what every woman needs to know
  • endometriosis;
  • dysplasia and cervical cancer;
  • uterine fibroids;
  • ovarian cyst;
  • premenstrual syndrome;
  • HPV infection in all its manifestations (papillomas, warts, respiratory papillomatosis).

The manual has a disclaimer: before using consult your doctor. Is this really necessary, since Indinol obviously should not be used with a lack of estrogen in the body.

Indinol recommended to take 400 mg (2 capsules 2 times) a day before meals daily for 3 months.

 Indinol - drug or another fiction?

Contraindications Indinol

  • idiosyncrasy of the individual components of the drug;
  • pregnancy and lactation (strictly contraindicated - estrogens play an important role in child bearing);
  • reception, together with agents which reduce gastric acidity.

 Indinol - drug or another fiction?

Side effects

The manual says that the side effects have not been identified (Supplements are not clinical trials). But many women report weight gain while taking this drug, which is not surprising at lower levels of estrogen. In addition, judging from the reviews can occur over a long process of oocyte maturation, that will create problems conceiving (estrogens are active precisely in the first half of the menstrual cycle, helping to egg maturation).

Biologically active food supplements are necessary, they are an effective form of primary and secondary (prevention of recurrence of the disease) prevention, as well as an auxiliary correction of many acute and chronic diseases. The peculiarity of them is that they can be taken as the sick and healthy, because their action should not go beyond the physiological norm. Indinol is such a useful organism Supplements, which operates within the physiological norms.

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