Thrush and clotrimazole - important dosage

October 27, 2012

 yeast clotrimazole
 Treatment of thrush (candidiasis urogenital) is rather complicated and long. At present we know a lot of antifungal drugs that are successfully fighting with thrush. Enough effective treatment for urogenital candidiasis is clotrimazole. But keep in mind that it is unacceptable self-treatment of thrush Treating Thrush: how to get rid of bad fungus  Treating Thrush: how to get rid of bad fungus
   clotrimazole Clotrimazole - effective against bacteria  Clotrimazole - effective against bacteria
 As in the treatment with this drug you must not only comply with the dosage and duration of the course. Clotrimazole affordable and practically has no contraindications.


What is clotrimazole

Clotrimazole is the main active ingredient of drugs such as Canison, Candide, Kanesten, imide, and others. It refers to the group Clotrimazole antifungal agents imidazole derivatives and is applied only for local therapy. The antifungal effect of clotrimazole is based on the violation of ergosterol synthesis and cell membrane of the fungus. The drug has a broad spectrum of activity and is effective against yeasts, especially Candida albicans, Candida tropicalis? Candida krusei and others. In addition, Clotrimazole has antifungal effect on fungi, and also possesses antibacterial properties against streptococci and staphylococci.


Pharmacokinetics and indications for use of clotrimazole

In the treatment of urogenital candidosis clotrimazole administered vaginally, wherein the drug has a local effect only, since through the vaginal mucosa absorbed its minimum amount.

In addition to yeast, clotrimazole indicated for fungal infections of the skin that are caused by dermatomitsetami, and Blastomyces fungi.


Dosage and route of administration

In the treatment of thrush should be remembered that only applied topically clotrimazole (vaginally).

Clotrimazole is produced as a 1% cream in tubes of 20 grams, a 1% solution and 15 ml of intravaginal tablets of 100 mg. Vaginal tablets are administered for six days, once a day (preferably at night before going to bed). If necessary, treatment is repeated. Allowed to blur the skin of the perineum and vulva one percent cream in the presence of urogenital candidiasis Urogenital candidiasis - an infection will not spare anyone  Urogenital candidiasis - an infection will not spare anyone

If you have thrush in men (candidal balanitis) must be careful massaging clotrimazole cream applied to the glans penis. The drug is administered two or three times a day for six to twelve days.


Application via vaginal tablets Vaginal Applicator

Vaginal tablet is removed from the package and is embedded in the applicator. Then vaginal applicator with tablet must enter deeply into the vagina and pushing the piston up to its end. After the introduction of the vaginal tablets vaginal applicator should be thoroughly rinsed with warm water (do not use hot water).


Side effects of clotrimazole

As noted above, Clotrimazole has virtually no side effects, because they do not irritate the vaginal mucosa, is not absorbed and has no systemic effects on the body. Extremely rare hypersensitivity to the drug.



Clotrimazole is not recommended for use in case of hypersensitivity to the drug. In addition, clotrimazole is not allowed to use in the first trimester of pregnancy (according to some authors can not be used during pregnancy and breast-feeding).



Treatment for thrush intravaginal tablets or ointment "Clotrimazole" should be carried out between menstrual cycles (ie you can not use the drug during menstruation). In addition, the treatment of urogenital candidiasis should be combined with the sexual rest for the prevention of re-infection. Treatment of thrush should be carried out simultaneously in both sexual partners.


Drug Interactions

Action clotrimazole reduced by the simultaneous use of polyene antifungals such as amphotericin B, nystatin Nystatin - help with candidiasis  Nystatin - help with candidiasis
 , Natamycin and others.

Anna Sozinova

Article Tags:
  • treatment of thrush

Polyp endometrial cancer: how is formed and shows

January 26, 2013

 polyp endometrial cancer
 One of the perennial problems of women of all ages and nations are gynecological diseases. Gynecologic Pathology is so diverse that it is impossible just to list all the types of female diseases. One of them is considered a polyp endometrial cancer. Like all women's diseases, endometrial polyp in need of treatment. According to statistics, this pathology occurs in fifty percent of women suffering from gynecological problems, and more likely to occur in the reproductive age, but may cause endometrial polyps, as well as in premenopausal Premenopausal women - one step in a woman's life  Premenopausal women - one step in a woman's life
 And postmenopausal.

 Polyp endometrial cancer: how is formed and shows

What is a polyp endometrial cancer

Polyp endometrial cancer is considered to be a focal endometrial hyperplasia Hyperplasia endometrial cancer - requires timely detection and treatment  Hyperplasia endometrial cancer - requires timely detection and treatment
 And often develops in the basal layer giperplazirovanogo endometrium. On histological structure of the polyps are the following forms:

  • gland (derived from the basal layer of the endometrium and are made up of stroma and glands, which are often extended lumen);
  • glandular-fibrous polyps (a part of them enters the connective tissue stroma and small amounts of iron);
  • fibrous polyps (this formation of connective tissue, they are often kollagenizirovany, virtually no glands).

In the case of intensive proliferation gland polyps are adenomatous acquire the character, that is precancerous. Polyps are characterized by circulatory disorders, hemorrhage and necrosis and inflammation in them.

 Polyp endometrial cancer: how is formed and shows

The mechanism of formation

Most researchers believe that in the pathogenesis (development mechanism) endometrial polyps into play by the same factors as in the endometrial hyperplasia, namely violation of ovarian function, which leads to excessive production of estrogen deficiency and generation progestogens (progesterone). Some scholars are inclined to think that endometrial polyps occur against the backdrop of glandular-cystic hyperplasia of the endometrium, inflammatory diseases of the uterus (endometritis), as well as on the background of dysplastic (violation) of the endometrium. In addition, in the development of endometrial polyps of the uterus are often guilty of diseases such as overweight, increased blood sugar Blood sugar - a very important indicator  Blood sugar - a very important indicator
   and high blood pressure. By the predisposing factors of endometrial polyps include: diagnostic curettage of the uterus Curettage - how dangerous it is?  Curettage - how dangerous it is?
 , Abortions, uterine surgery (conservative myomectomy), obstructed labor and inflammatory diseases of the pelvic organs.

 Polyp endometrial cancer: how is formed and shows

Clinical manifestations

The clinical picture of uterine endometrial polyps is very diverse and is directly linked to the woman's age, hormonal ovarian function and the presence of concomitant gynecological pathology (uterine fibroids, endometriosis, uterine body, inflammation of the uterine appendages).

A characteristic symptom of endometrial polyps is a violation of the menstrual cycle .  If endometrial polyp developed against the background of the normal functioning of the mucous membrane in women of reproductive age, the patients complain of premenstrual sukrovichnye or intermenstrual spotting .  The cycle in such cases saved, but there is an increase menstrual blood loss .  In addition, women of childbearing age have iron-fibrotic and fibrotic polyps can lead to profuse and prolonged menstruation (menorrhagia) .  If there are anovulatory menstrual cycles on a background of endometrial glandular polyps, the patient complained of irregular cycle and the appearance of uterine bleeding (this is due to necrotic changes in the lining of the uterus and hormonal disorders) .  In postmenopausal women more likely to develop polyps fibrous .  A characteristic symptom in this case is a one-time moderate bleeding from the genital tract .  Often, patients with fibrotic polyps complain of aching pain in the abdomen and whites .  If you experience cramping pain speak of "birth" of the polyp and / or necrotic .

 Polyp endometrial cancer: how is formed and shows


Diagnosis of endometrial polyps is to conduct ultrasound of the uterus, hysteroscopy and gisterogrgafii. The most effective method of examination during a hysteroscopy endometrial polyps (introduction into the uterus of a special device that allows you to visually assess its mucosa).

Anna Sozinova

Article Tags:
  • Polyps