Lamisil - modern effective antifungal agent with broad spectrum of action. It is available in different dosage forms, it can be used in different types and forms of fungal infection. The drug is not toxic, with different formulations have different contraindications for the use of this drug.

Why Lamisil no toxic effect on the human body

Active ingredient is terbinafine lamizila that affects fungal cells, by inhibiting its metabolism in the cells. This Lamisil does not inhibit metabolism Metabolism: The basis of life of all living things   cells in the human body, which distinguishes it from previous generations of antifungal drugs.

Lamisil is an antifungal drug of last generation, whose effectiveness in the treatment of fungal infections has been repeatedly tested in practice, including the treatment of children after two years (for tablets). The combination of efficiency and lack of toxicity makes terbinafine drug of choice in the case where the pathogen exhibits fungal infection sensitivity thereto (based on laboratory tests).

Do lamizila side effects

Side effects are manifested mainly in the reception of the drug inside (Lamisil tablets). In this case, the major side effects arise on the part of the digestive system: pain and discomfort (discomfort) in the upper abdomen, taste disturbances, nausea, sometimes vomiting, and diarrhea.

But the main danger is that Lamisil may have a negative effect on the liver. There are side effects are very rare, however, there are cases where violations laboratory values ​​of liver function, and there are such signs as jaundice and pain in the right upper quadrant.

Sometimes there are also side effects such as muscle and joint pain, decrease blood of granular white blood cells (granulocytes, this leads to decreased immunity), platelets (there is excessive bleeding and bleeding), hair loss. There may be allergic reactions, which are sometimes very difficult to proceed with necrosis - the withering away of the surface skin cells, and so on (Stevens-Johnson syndrome, toxic epidermal necrolysis).

When using lamizila formulations for external use may cause skin irritation and allergic reactions, which are sometimes difficult to distinguish from each other. Therefore, the appearance of the skin at the site of lamizila redness, swelling, rash of any kind, you need to see a doctor to solve the question of the continuation or repeal of treatment (allergy require immediate discontinuation of the drug, and if skin irritation is sometimes possible to continue treatment).

Is it possible to overdose lamizila

Overdosing lamizila is only possible if it is ingested. But this preparation is so toxic that to overdosage symptoms appeared, it is necessary to take not less than 20 tablets of the drug (or 5 g of active principle, while in one tablet contained 250 mg). Overdose is manifested in the form of nausea and vomiting (rare), pain in the upper abdomen and hypochondrium, headaches and dizziness.

If you suspect an overdose of the drug should wash the stomach to take a few tablets of activated charcoal Activated carbon - old but indispensable   and if the condition does not improve, call an ambulance.

External dosage forms lamizila overdose usually do not cause.

Contraindications for use lamizila

Lamisil tablets are contraindicated in case of hypersensitivity to its components of the patient, for children up to two years for violations of liver function, as well as during feeding baby Breastfeeding - a personal choice   feeding (the drug is excreted in human milk).

During pregnancy intake lamizila Lamisil - a modern drug to help cope with fungal infection   I shall be assigned a doctor and only for health reasons. Such precautions are necessary because the clinical trials of the drug (in pregnant women) were not carried out. Laboratory studies (in animals) lamizila negative impact on the mother and fetus are not revealed.

Precautions Lamisil tablets should also be applicable in case of violation of renal function, chronic alcoholism, cancer (including blood diseases), metabolic diseases, disorders, blood vessel patency limbs.

External lamizila dosage forms can not be applied under the age of 12 years (Lamisil Uno under the age of 15 years) and hypersensitivity to its components of the patient.

Lamisil - a modern, effective antifungal drug that does not have increased toxicity and has very few side effects and contraindications.

Galina Romanenko

Actually mikosist tablets are not produced. Hungarian pharmaceutical company Gedeon Richter manufactures mikosist capsules for oral administration in various dosages and as a solution for infusion. Mikosista capsules used in the treatment of many fungal infections.

How do tablets (capsules) Mikosista

Mikosist (active substance - fluconazole) - is an antifungal medication wide spectrum of action. For oral mikosist available in hard gelatine capsules of 50, 100 and 150 mg. Such a diverse dosage useful for the treatment of various fungal infections.

After ingestion mikosist rapidly absorbed from the gastrointestinal tract into the bloodstream, where it comes in various tissues and biological fluids. Mikosist selectively inhibits the synthesis of sterols (they are a part of cell membranes) in fungal cells. This occurs in cells by inhibiting the fungal enzyme system.

A similar enzyme system in human liver cells is practically not inhibited. However, sometimes it gives mikosist side effects of the liver, which develop due to the suppression of the function of this enzyme system.

Displayed mikosist urine largely unchanged.

Mikosist is active against many fungi that can cause fungal infections in humans: candidiasis, cryptococcosis, microspores trichophytosis, coccidioidomycosis, paracoccidioidomycosis, histoplasmosis.

With which diseases and how to apply

Mikosist oral is used to treat fungal infections of the skin and mucous membranes. In generalized (multiple lesions of organs and tissues) lesions and lesions of the internal organs mikosist usually applied in the form of intravenous drip infusion.

The main application mikosist capsules found in the treatment of candidiasis - skin and mucous membranes of the yeast genus Candida. Candidiasis of the oral mucosa, which often develops when wearing dentures, a fungal infection may move to the throat, esophagus, larynx, trachea and bronchi. For the treatment of such diseases mikosist administered 50-100 mg once a day for one - two weeks.

When immunodeficiency, such as HIV infection, a fungal infection frequently develops. For its prevention mikosist appoint 150 mg once a week. In the treatment of cancer patients used chemotherapy and radiotherapy, which also causes a decrease in immunity, and the threat of fungal infections. In this case mikosist assigned 50 mg per day as long as the patient is at risk for disorders of immunity, i.e. receiving treatment facilitates its reduction.

Widespread use mikosist found candidiasis of genitals Candidiasis genitals: possible severe complications   - Thrush in women Thrush in women - the relevance of the problem   and men. When thrush mikosist take a one-off - 150 mg capsule. If you disturb the constant recurrence of thrush, the mikosist administered once a month for 150 mg for several months, and sometimes up to a year. Candidiasis of skin designate Mikosista 150 mg once per week or 50 mg every other day for two to four weeks.

When fungal infections of the nails (onychomycosis) 150 mg administered Mikosista Mikosist - another remedy for thrush   once a week for as long as the affected nail fungus completely replaced by healthy, that is, from three months to a year.

Who should not take

Absolute contraindications for receiving Mikosista are individual intolerance of components of the drug by the body of the patient, breast-feeding Breastfeeding - a personal choice   feeding, child up to the age of six months and the simultaneous use of certain antihistamines (terfenadine and astemizole), which is the same as mikosist can cause cardiac arrhythmia.

Relative contraindications (mikosist take is possible, but with caution) are pregnancy, cardiac arrhythmia, simultaneous Mikosista with drugs, decomposing in the liver enzymes, the activity of which can suppress mikosist (eg, rifabutin).

Side effects

Mikosist capsules for oral administration are usually very well tolerated. Nevertheless, the emergence and possible side effects such as nausea, vomiting, bloating, abdominal pain, changes in taste, abnormal liver function until hepatitis and hepatic necrosis. There may also be headaches, dizziness, convulsions, blood disorders (reduction in the blood platelet count and white blood cells), abnormal heart rhythm, increased blood content of the amount of cholesterol and lowering of potassium, renal dysfunction, alopecia (hair loss), and allergic reactions.

Galina Romanenko