Aspirin - a non-steroidal anti-inflammatory drug (NSAID), a non-narcotic painkillers, has also antiplatelet properties - increased ability to prevent blood clots. All of these beneficial properties are widely used in a variety of diseases and conditions. But these properties, as well as side effects not allow the use of aspirin during baby feeding Breastfeeding - a personal choice   feeding.

Aspirin can threaten the life of the baby

Aspirin (active substance - acetylsalicylic acid) after administration of the tablet is rapidly absorbed from the gastrointestinal tract into the bloodstream, rendering on its main body and side-effects, and then excreted in urine. If a woman is breastfeeding, it is part of the aspirin excreted in human milk.

Once in the body of an infant Baby man, though with a little finger Aspirin also shows its main and side effects, which can have a negative impact on the child's body, and even threatened his life.

The antithrombotic effect of aspirin and its impact on the child's body

Aspirin inhibits the synthesis of thromboxane A2 - a substance that activates the platelets, including their ability to adhesion and aggregation (sticking to the walls of blood vessels and the formation of clumps which then become the basis of blood clots).

As a result of entering into the bloodstream aspirin baby had reduced the ability of blood to clot, which may manifest itself in increased bleeding in the skin and the appearance of small hemorrhages. Long-term use of aspirin nursing mother may even cause the child's internal bleeding. This is called hemorrhagic diathesis Diathesis in children - an integrated approach   and poses a threat to the life of the baby.

Like aspirin can affect the gastrointestinal tract of the child

Aspirin inhibits the formation of the enzyme cyclooxygenase (COX), which leads to a reduction in the stomach wall biologically active substances prostaglandins, whose main function is to protect the gastric mucosa of various mechanical and chemical influences. In adults any longer aspirin in high doses leads to the formation of ulcers and erosions of the stomach wall. In children, gastric mucosa is thin, delicate, blood vessels close to the surface and are easily injured.

Maternal use of aspirin can cause internal bleeding from the blood vessels of the stomach. Bleeding can be significant due to the fact that under the influence of aspirin reduced rolling capacity of the blood. Of course, from taking one tablet of aspirin like effect it will not be needed long enough taking it.

"Aspirin" asthma and other manifestations of allergy in the child's mother when taking aspirin

Aspirin often cause allergies, including so-called "aspirin" asthma, in which the intake of aspirin or any other product in this group (NSAID) there are attacks of bronchospasm.

Chronic administration of aspirin mother allergy can manifest as bronchospasm, in the form of the common cold in a child, while in the nasal cavity and sinuses child can grow polyps. Allergy there may occur not only aspirin, but other nonsteroidal anti-inflammatory drugs.

What other side effects can cause a child receiving aspirin nursing mother

When receiving a nursing mother aspirin and simultaneous viral infection disease of the child he may develop Reye's syndrome - a serious liver disease with severe disturbance of its function and brain damage. Because of the possibility of Reye's syndrome are not allowed to prescribe aspirin to children under 15 years old, especially if they suffer from a viral infection.

Chronic administration of high doses of aspirin in the mother and baby can decrease the number of red blood cells in the blood and hemoglobin (iron deficiency anemia), white blood cells (this will lead to decreased immunity) and platelets (cause increased bleeding).

There may also develop significant changes in the kidneys - interstitial nephritis, kidney necrosis, acute or chronic renal failure Chronic renal failure - what to do and how to be? . Violations can occur in the liver. In addition, it was found that long-term aspirin may develop hearing loss.

Aspirin - a drug that can not be taken during breast-feeding. If it becomes necessary to aspirin, then breast-feeding should be interrupted and resume after the completed treatment with this drug.

Galina Romanenko

The mechanism of action of aspirin

Nonsteroidal anti-inflammatory drugs (NSAIDs) - is drugs that exhibit analgesic and antipyretic properties in combination with a pronounced anti-inflammatory activity, which is as strong approaching steroid anti-inflammatory activity, but these drugs have a different chemical structure.

The very first drug in this group was aspirin, synthesized in 1869 from preparations derived from willow bark, antipyretic effect which has been known since Hippocrates. But only 30 years later, in the late XIX century, the pharmaceutical company Bayer decided to release its industrial way. Bayer made the right decision: Aspirin is today the best-selling drug in the world.

Aspirin (INN - acetylsalicylic acid) belongs to the group of NSAIDs and has analgesic, antipyretic, anti-inflammatory and antiplatelet (prevents clot formation) effect.

The mechanism of action of aspirin is based on the fact that it inhibits the action of cyclooxygenase enzymes, which are involved the synthesis of prostaglandins. Prostaglandins - biologically active fatty substances contained in all organs and tissues of the body. They are formed from unsaturated fatty acids under the influence of special enzyme proteins - so-called cyclooxygenase and have versatile physiological activity, including the active members are inflammatory processes. Aspirin inhibits the cyclooxygenase, thereby reducing the production of prostaglandins and thus - to reduce their many and diverse effects, including reduced inflammation in the tissues.

Antipyretic and analgesic effect of aspirin is associated with its effect on the centers of thermoregulation and pain sensitivity, which is in the brain.

Aspirin also reduces clot, affecting the processes of aggregation (bonding) of platelets, so it has found application in the treatment and prevention of thrombosis.

Because of the negative effects on the human body, first of all, it should be noted its irritating effect on the mucous membrane of the gastrointestinal tract (including the formation of ulcers, followed by bleeding), and the ability to cause allergic reactions.

Indications for use

Aspirin is used for prevention and treatment of the following diseases and conditions:

• as an analgesic to relieve or alleviate headache, toothache, sore throat, pain during menstruation, pain in muscles and joints, back pain;
• as an antipyretic elevated body temperature in cold and other infectious and inflammatory diseases;
• as an anti-inflammatory rheumatic diseases, rheumatoid arthritis, ankylosing spondylitis;
• how antiagregatine agent (prevents blood clots) for varicose veins Varicose veins - the operation is inevitable? , Thrombophlebitis, thrombosis;
• for the prevention of myocardial infarction and stroke in patients with hypertension, coronary heart disease and atherosclerosis.

Contraindications

Aspirin is contraindicated in:

• if you are hypersensitive to the drug;
• gastric ulcer and duodenal ulcer, erosive gastritis, ulcerative colitis (inflammation of the large intestine);
• in hemorrhagic diathesis Diathesis in children - an integrated approach   (bleeding disorders accompanied by bleeding disorders);
• bronchial asthma, occurring in patients receiving aspirin and other NSAIDs;
• pregnancy (especially in I and III trimester) and breastfeeding Breast-feeding: feed - and no nails!   Child;
• Children up to 15 years with viral infections (may experience severe disorders of the central nervous system and liver);
• If the kidney function and liver;
• while the treatment of drugs that lower blood clotting;
• while taking alcohol.

Aspirin before heart surgery reduces the risk of post-operative acute renal failure

The study involved 3219 patients were divided into two groups: those who are within five days before the operation took aspirin (2247 patients) and those who do not accept it. Although the researchers do not have accurate data on the magnitude of doses, the normal daily dose is 80-325 mg. It is assumed that the value of the test dose is within these limits.

After analyzing the results according to different characteristics such as age, diagnosis, and others taking the drug, the researchers found that preoperative use of aspirin is associated with a significant reduction in the incidence of postoperative acute renal failure: in the first group, it was observed in 85 of 2247 patients ( 3.8%), the second group - in 65 of 972 (6.7%). Thus, we can conclude that aspirin reduces almost twice the chance of developing acute renal failure after heart surgery.

Acute renal failure - a common postoperative complication, which has a significant impact on the probability of survival of the patient. This condition increases the required hospital stay after surgery, the likelihood of developing other complications and death. Acute renal failure occurs in 16-40% of patients undergoing surgery is not the heart; severity vary depending on how the patient's kidneys were functioning prior to surgery. Despite extensive research in this area, scientists still could not understand why developing this complication. Likely causes are inflammatory and neurohormonal factors, limiting blood flow, renal toxicity, or a combination of all factors.

For many years, aspirin is widely used as anti-platelet and anti-inflammatory agent in the non-surgical treatment of cardiovascular diseases. Now it is used in surgery, for which he conducted the study, doctors called miracle drug aspirin. At this time, research is continuing and may soon will open new ways of aspirin.

Aspirin may protect against melanoma

In the first phase of the study, scientists collected and examined subjects, some of whom regularly took aspirin for different periods, while others do not take it at all. Over the next 12 years to carry out regular inspection of the study participants. The subjects who regularly took aspirin less than one year, the likelihood of developing melanoma by 11% turned out to be lower than that of women who did not take aspirin. Those who took aspirin for one to four years, decreased risk of melanoma by 20%. Finally, women who took aspirin for five years or more, the risk of melanoma was 30% lower than those who did not take aspirin. The risk is calculated according to age, education, income level, type of skin How to determine your skin type And other factors that may influence the likelihood of developing melanoma.

Based on the research result suggests that aspirin has a chemopreventive effect. This information is consistent with the results of other studies that have linked NSAIDs, including aspirin, with a lower risk of developing breast cancer, colon and rectum, stomach. This effect is explained by the ability of aspirin to inhibit cyclooxygenase-2, which stimulates the inflammatory processes in the body.