Doxycycline and alcohol can not be combined. Despite the relatively low toxicity of doxycycline, the drug, like the rest of the antibiotics tetracycline, may cause some side effects. One such side effect is liver toxicity - property characteristic and alcohol.
Hepatotoxic effects of antibiotics tetracycline and alcohol
Tetracycline is a natural antibiotic
Antibiotics - whether they will help you in the foreseeable future?
, Produced radiant fungus. In recent years, by enzymatic cleavage tetracycline
Tetracycline - a natural broad-spectrum antibiotic
and improvement of its chemical structure created semisynthetic preparation of this group - doxycycline, which has the same mechanism of action, but it is more effective and less toxic.
All antibiotics tetracycline inhibit intracellular protein production in bacterial cell, whereby further development of suspended microorganisms (bacteriostatic effect). They also block the entry of pathogens into the cells of some trace elements belonging to the bacterial enzyme that slows their metabolism.
Thus all tetracyclines have several side effects, doxycycline is no exception, despite the fact that its toxicity is much lower than that of natural tetracyclines. One of the most dangerous side effects of doxycycline is a toxic effect on the liver cells (hepatotoxicity).
The recommended dose for the treatment of hepatotoxicity doxycycline practically not shown, but at higher dosages, long-term use and in combination with other hepatotoxic substances adverse effect on the liver of doxycycline may be significant.
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Main adverse effects of doxycycline combination with alcohol takes place on the liver, as both of these compounds have hepatotoxic effects.
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The extent of the impact will depend on the dose received and strength of alcohol, and from individual to individual, including from his inheritance. Therefore, such a combination of one patient may not cause significant harm, and another cause severe complications in the form of toxic hepatitis
Toxic hepatitis - the impact of harmful substances on the liver
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Doxycycline may cause side effects in other organs of digestion, as it irritates the mucous membrane of the stomach and intestines. Side effects may appear as nausea, vomiting, diarrhea, pain during bowel. The treatment with doxycycline
Doxycycline - penetrates into the tissue cells
it is also possible ulceration of the esophagus (erosive esophagitis), stomach (erosive gastritis, acute gastric ulcer), colon (exacerbation of duodenal ulcer, ulcerative enterocolitis).
Alcohol, particularly strong, also has a negative effect on the gastrointestinal tract, resulting in all the side effects of doxycycline increase.
Exposure to doxycycline and alcohol on the central nervous system
The simultaneous use of doxycycline and alcohol can also have negative effects on the central nervous system.
Doxycycline has the side effects of the central nervous system as a benign intracranial hypertension (decreased appetite, vomiting, headache, blurred vision), a toxic effect on the central nervous system (dizziness or instability). In some cases, doctors do not recommend that patients while taking doxycycline to drive a car.
Alcohol also has a negative effect on the central nervous system in the form of toxic effects on brain cells. The combination of doxycycline and alcohol can cause severe drowsiness or agitation, slowness and blurred speech, disorientation to time and place of residence, confusion and impaired consciousness, shortness of breath or cessation of breathing, hallucinations, seizures, rigidity (stiffness) of muscle, heart rhythm disorder.
Why not combine with alcohol intake of doxycycline
Drinking alcohol accelerates the decay of tetracycline antibiotics (including doxycycline) and their more rapid excretion from the body, reducing the concentration of drug in blood plasma and, accordingly, the efficiency of its therapeutic effect.
Therefore, even if the combination of doxycycline alcohol does not cause severe complications in the liver, the gastrointestinal tract or the central nervous system, it is guaranteed to lead to a decrease in the effectiveness of treatment.
Acceptance of doxycycline is not combined with the admission of alcoholic drinks of any fortress.
Galina Romanenko