- Prolactin - effect on the body is not fully known
- Hormone production
Pituitary hormone prolactin and its role in the regulation of various body functions
Prolactin - a hormone that is produced by the pituitary gland (the main endocrine gland located in the brain), and has a broad spectrum of biological activity. The chemical structure prolactin is a protein.
Prolactin stimulates growth and development of the mammary glands, increased number of lobes and ducts therein, production, secretion and maturation of colostrum, colostrum transformation in mature milk, growth and function of the sebaceous glands, growth of the internal organs. Prolactin regulates the processes of childbirth, stimulates the manifestation of the maternal instinct. In men, prolactin stimulates growth of the prostate and seminal vesicles.
Prolactin inhibits the maturation of the egg in the ovary, delaying the secretion of follicle stimulating hormone (FSH), which contributes to the process, extend the existence of the corpus luteum and release of progesterone, estrogen reduces the secretion of ovarian follicles, thus decelerating ovulation
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and the advent of a new pregnancy during lactation
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child.
Prolactin also has oncogenic effect, causing the development of tumors.
What affects the production of prolactin
Lactotropic function of the pituitary gland (the production and release of breast milk) is controlled by the Department of the brain called the hypothalamus. Hypothalamus constantly inhibits the function primarily through the neurotransmitter (substance with which the excitation is transmitted to the nerve cells) dopamine. Activation of prolactin occurs after birth with another substance secreted by the hypothalamus - thyrotropin.
The direct stimulating effect on the secretion of pituitary prolactin have a female sex hormone estrogen, which also delayed the production in the hypothalamus of substances that prevent the development of prolactin. Increased secretion of prolactin also cause stress factors, alcohol, drugs and medicines, have a stimulating effect on the psyche, sexual intercourse, irritation of the cervix and nerve endings in the breast nipple. Prolactin increases during pregnancy and breast-feeding the child. In pregnancy, increasing the level of estrogen that causes the increase in the concentration of prolactin lactation but not due to the large number of female sex hormone progesterone
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, Retarding the process. Progesterone drops sharply after birth, helping the beginning of lactation.
Active prolactin begins when the child was first put to the breast, it starts to irritate the nipple, on which there are receptors that send signals to the hypothalamus via the spinal cord. The hypothalamus receives a signal, begins the selection of biologically active substances that stimulate prolactin and inhibiting dopamine release. Under the influence of prolactin lactation begins.
Prolactin secretion is reduced when taking drugs that block the production of estrogen and dopamine. The slight decrease of prolactin secretion occurs while taking thyroid hormone
Thyroid hormones: mechanism of action and physiological effects
And corticosteroids.
Violation of prolactin
Violation of prolactin by the pituitary gland is expressed in an uncontrolled increase or decrease in the formation of prolactin. Increased secretion of prolactin (gipergalaktiya) leads to spontaneous expiration of milk from the nipple (galaktoree). Sometimes elevated prolactin associated with pituitary tumors producing prolactin, as well as disorders of the hypothalamus, decreased thyroid function, ovarian, liver, and kidneys. At elevated prolactin female menstrual cycle is disrupted, leading to infertility, decreased sexual drive, increased breast size, they develop cysts and breast, which are pre-cancerous diseases.
Insufficient secretion of prolactin (hypogalactia) causes underdevelopment of the breast and the violation of their functions. Such a condition occurs when the functional impairment of the pituitary gland, which may occur after heavy blood loss during childbirth, when perenashivanie pregnancy (decreases the amount of estrogen in the blood, and thus the production of prolactin), while taking certain medications (eg, anticonvulsants, estrogens, and others.) . For the treatment used hypogalactia prolactin isolated from the pituitary glands of cattle and pigs. The drug enhances lactation in the postpartum period.
Prolactin - vital pituitary hormone whose action on the body is not yet fully understood.
Galina Romanenko