- Enalapril - lowers blood pressure
- Mechanism of action
What is an ACE inhibitor
In the body under the action of the enzyme renin resulting in kidney, produced angiotensin I, which is under the influence of the angiotensin-converting enzyme (ACE) Angiotensin II is formed, causing the active spasm of blood vessels.
There are drugs that can inhibit the activity of angiotensin converting enzyme, they are called ACE inhibitors.
Enalapril and its mechanism of action
Enalapril belongs to the drugs, ACE inhibitors and produced by different pharmaceutical companies under different names. But the international drug name is written on the packaging always, it enalapril. In our country, the most widely used drugs are Enap (KRKA, Slovenia), Enam (India).
Enalapril - lowering blood pressure drug mechanism of action is associated with inhibition of the activity of angiotensin-converting enzyme (ACE) inhibitors. Inhibition of ACE results in vasodilation, an increased formation of substances (kinins and prostacyclin) also possessing vasodilating action, and has some diuretic action. Along with a reduction in blood pressure medication reduces the load on the heart muscle, improves blood circulation and respiratory function, lowers resistance in the blood vessels of the kidneys, which helps normalize the blood flow in them.
Enalapril gradually lowers blood pressure and usually does not cause any changes in heart rate and minute volume. It prevents expansion of the left ventricle, improves blood flow to the heart, reduces the sensitivity of the heart to ischemic injury. After myocardial infarction drug reduces the development of cell death of heart muscle, improves metabolism and reduces the incidence of arrhythmias that occur after the restoration of blood supply to the heart muscle.
Indications for use of enalapril are the following conditions:
- hypertonic disease;
- increased blood pressure in kidney diseases (also in renal failure
Kidney failure - when treatment is vital
and kidney disease in diabetes mellitus);
- Chronic heart failure (in combination therapy);
- dysfunction of the left ventricle of the heart as a consequence of increased load due to high blood pressure (in combination therapy).
Enalapril may be used in combination with other blood pressure lowering agents.
Contraindications for use
Contraindications for use of enalapril (Enap, Enam et al.) Are:
- Hypersensitivity to enalapril, formerly an allergic reaction in its application;
- angioedema in the past (including those associated with the use of ACE inhibitors);
- chronic renal failure;
- porphyria (violation of pigment metabolism);
- Pregnancy and breast-feeding
Breast-feeding: feed - and no nails!
Caution should be used enalapril in violation of the liver and kidneys, as well as in combination with a diuretic drug, since it is possible sharp decline in blood pressure.
In all cases, too marked decrease in blood pressure gradually reduce the dose.
Side effects with the use of enalapril
Enalapril is generally well tolerated and in most cases does not cause side reactions requiring discontinuation of the drug, however the side effects are:
- Central nervous system: headache, dizziness, fatigue;
- The respiratory system: dry compulsive cough, dyspnea;
- the gastro-intestinal tract include nausea, diarrhea, sometimes dysfunction of the pancreas
Diabetes and pancreas - the things you need to know
, Liver abnormalities stool;
- on the part of the cardiovascular system: a sharp drop in blood pressure, especially at sharp rising, irregular heartbeat, heart pain
Pain in the heart - always consult a doctor
- Allergic reactions: skin rash, isolated cases of angioedema of the face, throat.
Very rarely, when used in high doses can appear neurological disorder: insomnia, increased nervous irritability, bad mood, impaired balance, tinnitus. The rare side effects are also hair loss, inflammation in the area of language.
During treatment with enalapril is forbidden to drink alcohol, as Alcohol increases blood pressure lowering effect of the drug.
What if I overdose
If overdose can occur a sharp drop in blood pressure, up to fainting. In that case, should:
- put the patient with elevated legs;
- release from compressing the chest of clothes and open the window or the window;
- to drink lightly salted water;
- if the condition does not improve, then call an ambulance.
If your doctor has prescribed enalapril and you have no side effects when it is received, then, with proper reception and lack of complications of hypertension, you forget about what suffering this disease.