- Andipal - if not the strength to bear the pain
- Mechanism of action
Andipal - drug used for the symptomatic therapy, i.e. designed to neutralize symptoms such as pain (different origin from migraine and ending cramping pains in the gastrointestinal tract), and increased blood pressure.
Brief general description of the
Andipal - preparation containing in its composition more active components. The international non-proprietary name is: bendazol metamizol + solution + papaverine + phenobarbital. Thus, the combined effect has andipal, acting simultaneously on different links in the pathogenesis of the disease.
Preparation simultaneously relieves pain and helps to relax the smooth muscle cells that make up the walls of blood vessels and of the gastrointestinal tract.
It should be emphasized that it does not eliminate the cause of the disease, but only reduces the manifestations of the disease, preventing the patient to live in a normal operating mode.
The drug has analgesic and antispasmodic effect. Relaxation of smooth muscle cells reduces the total peripheral vascular resistance (they expand, leading to the removal of spasm of arterioles and improve circulation in the periphery), an overall reduction of blood pressure (which is used in hypertensive crises), the removal of excessive tone of the blood vessels of the brain (eg, severe headaches pain), leveling of spasm of the gastrointestinal tract (in intestinal colic and other gastrointestinal diseases accompanied by pain, spasticity caused by the walls of the digestive tract), whose walls also contain smooth muscle cells. Phenobarbital, which is part of andipola causes some sedation and potentiates the effect of other components of the drug.
Andipal produced in the form of tablets (present in one pack of ten tablets). Each tablet contains 0, 25 g of dipyrone, 0, 02 g dibasol, 0, 02 grams of pentobarbital, 0, 02 g of papaverine
Papaverine - for pain caused by spasms of smooth muscles
hydrochloride and various auxiliary agents (such as talc, starch, stearic acid). The tablets are white or yellowish in color.
In which case, it recommended the use of andipal
This drug is indicated for pain caused by a spasm of blood vessels, leading to deterioration of the circulatory organs. Also, he was appointed at the initial stage of hypertension in order to expand the blood vessels, helps to reduce blood pressure. Another indication for andipal - migraine. In addition, andipal prescribed for spasmodic pain associated with the gastrointestinal tract.
Adults designate one or two tablets inside. Multiplicity of reception - two or three times a day. Generally, treatment is from seven to ten days. Unless noted positive dynamics, joined by other medicines.
Contraindications to the use of the drug include individual sensitivity to andipalu or its components, lack of glucose-6-phosphate dehydrogenase, heart disease (violation of the atrio-ventricular conduction), liver failure or renal, hematologic disorders, porphyria, myasthenia gravis, pregnancy (especially the first three months) and lactation (breastfeeding).
Side effects occur infrequently. There are allergies (including immediate reactions, including anaphylactic shock), dyspepsia (nausea, diarrhea or constipation). Due to the fact that part of the andipal analginum, sometimes there are such negative phenomena as leukopenia, thrombocytopenia or agranulocytosis (due to the inhibitory action on the blood - long-term use of the drug). Due to presence of phenobarbital sometimes have depression
Depression - a little more than a bad mood
or ataxia (mainly concerned debilitated patients and elderly patients).
Interaction with other drugs
The hypotensive effect andinpala enhanced by combination with such drugs as nitrates (sustak, nitrosorbid, nitroglycerin and similar drugs), amiodarone, beta-blockers (such as metoprolol, propranolol, talinolol, oxprenolol) myotropic antispasmodics (eg, aminophylline, dipyridamole), ganglionic (pentamin) Corinfar, nifedipine.
The hypotensive effect andinpala reduced when combined with direct agonists (such as adrenaline and noradrenaline), tonics (such as Siberian Ginseng extract and Rhodiola rosea, ginseng root), holinomimetikami.
Also, please note that the simultaneous use of drugs which reduce intestinal absorption (such as activated charcoal
Activated carbon - old but indispensable
Overlying and astringents), reduces the effectiveness of andinpala.
Symptoms of overdose andinpala - dizziness
Dizziness - if the ground is slipping from under his feet
, Severe drowsiness, possible even collapse. As a first aid apply gastric lavage and administration of activated charcoal. The following shows the symptomatic treatment (to reverse the symptoms of overdose).
During the reception andinpala Caution should be exercised with regard to activities related to the increased attention (eg when driving a car or operating dangerous machinery), because the drug enters phenobarbital, able to reduce the speed of reaction. Furthermore, given the presence of dipyrone as one of the components during prolonged use andinpala need to perform regular blood tests to notice in time may oppression blood.
The drug should be stored in a dry, dark place. Shelf life andinpala is 2, 5 years.