Neyromultivit - a drug used to treat a variety of neurological diseases. It consists of vitamins from group B (B1, B6, B12), and the dosage is much higher than in prevention of vitamin-mineral complexes.

Vitamin B1 - thiamine

Thiamine is a result of the metabolic processes that occur in the human body turns into kokarboksilazu - an integral part of enzymes. Recent increases the speed of biochemical processes many times. B1 is involved in fat, protein and carbohydrate metabolism and helps the nerve impulses between nerve cells.

Vitamin absorbed in the small intestine, and when entering the liver breaks down into metabolic products. They are removed from the body through the kidneys. If an overdose of thiamine, the B1 and released through the intestines.

Vitamin B6 - pyridoxine

It is required for normal operation of the peripheral and central nervous system. Pyridoxine part of the enzymes involved in the metabolism of amino acids and the formation of neurotransmitters (by these substances nerve cells exchange information).

B6 absorbed into the bloodstream in the small intestine and is metabolized in the liver. Because the organism is excreted in urine, and in excess of his hand and begins to stand out through the intestines.

Vitamin B12 - cyanocobalamin

This vitamin is necessary for normal blood formation and maturation of red blood cells (RBCs). He is involved in several biochemical reactions that are needed to sustain the human body (the synthesis of nucleic acids and proteins, amino acids exchange, carbohydrates and fats).

B12 reduces cholesterol in the blood, activate blood clotting and has a positive effect on the liver. Cyanocobalamin also affects the processes occurring in the nervous system, and its coenzyme forms are needed for cell growth and division.

Vitamin absorption occurs in the stomach and the upper intestinal tract, and is due to the presence there of a special intrinsic factor. Delivery tsiankobalamina performed in tissue specific transport protein.

It is metabolized in the liver, it is excreted mainly derived from bile. The small amount of B12 excreted through the kidneys.

Indications

Neyromultivit used in treatment of many neurological diseases. These include:

• Polyneuropathy of different origin - damage to the peripheral nerves, which occurs when exposed to toxic substances or metabolic disorders (eg diabetes mellitus Diabetes - threatening and incurable disease   or alcoholism);
• Neuritis - inflammation of nerve fibers;
• Neuralgia - nerve damage membranes (for example, neuralgia Neuralgia - the scourge of the elderly   Trigeminal The trigeminal nerve and its defeat: what happens in the body? , intercostal neuralgia);
• Paresis of the facial nerve;
• Cervical syndrome - various disorders of the cervical spine, which are characterized by pain and mobility disorders;
• Frozen shoulder syndrome - a disorder in which there is pain, a loss of motion in the shoulder joint;
• Radicular syndrome, the occurrence of which is associated with degenerative changes in the spine;
• Sciatica - sciatica Sciatica - warn it is too late ;
• Lumbago - a sharp pain in his lower back.

The drug improves metabolism in nervous tissue. Neyromultivit also improves the general condition of patients.

Contraindications and side effects

There are several contraindications for use neyromultivita. It:

• Increased individual sensitivity to the drug;
• Children's age, as safety and tolerability neyromultivita in this group of people are studied;
• During pregnancy and breastfeeding is not recommended to take the drug. This is due to the fact that no reliable data on the safety of neyromultivita in such periods.

Usually the drug is well tolerated, but in rare cases can appear side effects. In humans, there is nausea, quickens the heartbeat, sometimes develop skin reactions such as itching and hives.

The dosage regimen and overdose

Neyromultivit designate the interior of the tablet one to three times a day. The drug should be taken after meals, not liquid, and drink some water. The duration of treatment appointed the doctor individually, but we should not use the drug in high doses over four weeks.

Vitamins B1, B6, B12 - soluble and therefore do not accumulate in the body. Symptoms of overdose may appear only when receiving extremely high doses neyromultivita for a very long time.

Symptoms of an overdose of vitamin B1 after taking it inside not marked. After receiving more than two grams per day of vitamin B6 may occur with ataxia neuropathy (nerve damage with loss of coordination of voluntary movements), sensory disturbances and seizures. Sometimes developed hypochromic anemia (in which the reduced hemoglobin in red blood cells) and seborrheic dermatitis (skin inflammation as a result of exposure to microbes and increased sebum).

Signs of an overdose of cyanocobalamin when taking it inside appear very rarely. They appear in the form of acne and eczematous skin changes. If you have any of these phenomena should stop taking the drug and treat that will be aimed at eliminating the symptoms.

During treatment neyromultivitom should not take multivitamin complexes, which include vitamins of group B. At the same time taking neyromultivita and levodopa (the drug for the treatment of Parkinson's disease) reduces the effectiveness of last resort.

Prolonged treatment with anticonvulsant drugs (eg, phenytoin, carbamazepine) against application neyromultivita can contribute to thiamine deficiency. The same effect is observed for the simultaneous use with the drug alcohol.

Chronic fatigue syndrome - a complex disorder characterized by extreme fatigue, which can not be explained by any disease. Fatigue may be exacerbated as a result of physical or mental activity, but it does not go after the rest.

Chronic fatigue syndrome is a classic example of disease with unexplained physical symptoms.

The diagnosis is usually established according to the principle exclude other diseases. Patients complain of debilitating fatigue, and often do not find the strength to get out of bed for a few days, this disease can not be reduced to a constant feeling of fatigue. Patients are observed and high physical symptoms such as joint pain Joint pain - how to understand what is going on? Headaches, loss of visual acuity, allergy or sensitization.

The worst thing is that patients often face a lack of understanding of relatives who do not believe in the existence of the disease.

Symptoms

In chronic fatigue syndrome has eight major symptoms, plus a central symptom that gave it a violation of the name:

• Fatigue;
• Impairment of memory and / or concentration;
• A sore throat;
• Swollen lymph nodes in the neck and / or in the armpits;
• Muscle pain without apparent reason;
• The pain moves from one joint to another and does not cause inflammation or redness of the skin over the joint;
• Headache, previously characteristic of the patient;
• Lack of feeling of rest after sleep;
• The feeling of extreme fatigue that persists for more than 24 hours after physical or mental stress.

Fatigue can be a symptom of many diseases, such as infections or psychological disorders. Contact your doctor if you have symptoms such as extreme and / or constant fatigue.

Causes

Scientists have not yet been able to explain why developing Chronic Fatigue Syndrome Chronic fatigue - if life is not a pleasant experience . Probably, there are several factors involved that affect people who have an innate predisposition to the disease. Some of these factors are:

Viral infections. Since chronic fatigue syndrome often develops after a viral infection, the researchers suggest that some viruses can trigger this disorder. Probably such viruses include Epstein-Barr virus, human herpesvirus 6 and murine leukemia viruses. However, while there is no conclusive evidence of a link between the virus and chronic fatigue syndrome.

Abnormalities in the immune system. The immune system of people suffering from chronic fatigue syndrome, broken, but it is unclear whether there is enough of such a violation, to cause the disorder.

Hormonal imbalance. People with chronic fatigue syndrome is sometimes observed abnormal levels of hormones produced by the hypothalamus, pituitary and adrenal glands. The relationship between these disorders, however, is not installed.

Risk factors

Factors that may increase the risk of chronic fatigue syndrome:

• Age. Chronic fatigue syndrome is most susceptible people aged 40 to 50 years.
• Paul. Women diagnosed with chronic fatigue syndrome more often than men. Perhaps the reason for this is that women with the abuse often go to the doctor.
• Lifestyle. Overweight and sedentary lifestyle contribute to the development of chronic fatigue syndrome.

Complications

Possible complications of chronic fatigue syndrome:

• Depression;
• Social isolation;
• Various restrictions related to lifestyle.

Diagnostics

There is no specific diagnostic method that allowed you to establish that the patient has chronic fatigue syndrome. To diagnose this disorder, the physician should rule out a variety of other conditions, such as:

• Sleep disorders. Chronic fatigue can be caused by sleep disorders such as insomnia, sleep apnea, and others.
• Various diseases, such as anemia, diabetes, and decreased activity of the thyroid gland (hypothyroidism) can cause symptoms similar to the symptoms of chronic fatigue syndrome.
• Mental disorders. Fatigue can be a symptom of a number of mental health disorders, such as depression, anxiety Anxiety - how to distinguish normal from disease? , Bipolar disorder and schizophrenia.

Diagnostic criteria

To diagnose chronic fatigue syndrome may be, if the patient for 6 months or more there is severe fatigue, the reasons which could not be established, as well as at least four of the above symptoms of the disorder.

Expert opinion

Patients with chronic fatigue syndrome show signs of immunological, neurological and endocrinological disorders.

In addition to the strong moral and physical exhaustion, symptoms include sleep disturbances Dreams: how to understand our dreams , Cognitive problems, muscle and joint pain, sore throat and headache. Every eighth person there is chronic fatigue syndrome and fibromyalgia.

According to the American College of Rheumatology, fibromyalgia suffers 3-6 mln. US, 80-90% of whom are women. This condition is most often diagnosed in middle age, but at least one of the symptoms at an earlier age.

Recent studies indicate that fibromyalgia is the result of an internal biochemical imbalance, which causes physical symptoms such as pain, weakness, and impaired mental function. As this syndrome - that is, a set of signs and symptoms - not the disease, fibromyalgia can not be diagnosed based on a certain number of specific symptoms or reproducible test results.

Some hypotheses suggest that chronic fatigue syndrome is not caused by a virus, but is caused by disorders of homeostasis of endogenous hydrogen sulfide (H2S) and leads to mitochondrial dysfunction and failure of the ATP cycle.

Studies have shown that low, nontoxic doses of exogenous H2S is a temporary state of hibernation in mice. This reduces the basal body temperature, shortness of breath, decreased heart rate and respiratory rate, and strong metabolic slowdown. These characteristics do not differ much from the symptoms experienced by patients with chronic fatigue syndrome.

Furthermore, H2S effect on biological systems, which causes a failure, chronic fatigue syndrome, including neurological, endocrine and immune systems. Thus, the likely etiology of CFS may be associated with increased activity of endogenous H2S, which inhibits the use of oxygen by mitochondria.

Known treatments

• Physical exercise and behavioral therapy
• Black chocolate
• Probiotics