Riboxinum - a drug that stimulates the metabolism of the cells by increasing their energy potential. Especially effective Riboxinum acts on the cells of the heart muscle (myocardium), so it is often prescribed for coronary heart disease and other cardiovascular diseases.

The mechanism of action Riboxin

Riboxinum (INN - inosine) - is a drug belonging to the group means of normalizing the metabolism in tissues and reducing myocardial oxygen deprivation (hypoxia) tissues. Riboxinum discharged into tablets of 200 mg and a 2% solution in 10 ml ampoules for intravenous administration. Various pharmaceutical companies produced analogues Riboxin: inosine and ribonozin.

Riboksina mechanism of action is based on the fact that it is a nucleoside, i.e. precursor energy source ATP. How nucleoside Riboxinum easily penetrates into cells, increasing their energy balance and stimulating the synthesis of nucleotides. Especially effective Riboxinum acts on the cells of the myocardium and liver, improving metabolic processes in them. By activating the metabolism (especially glucose metabolism Glucose: The energy source , Which resulted in the release of energy) of myocardial cells are easier to tolerate the lack of oxygen (hypoxia), they restored the normal conduction of electrical impulses, which helps to restore heart rhythm.

Riboxinum also improves myocardial arterial blood supply, restores normal blood flow in the kidney, impaired following surgery on this organ. The process of tissue respiration is also improved by enhancing the exchange of pyruvic acid. It reduced the ability of blood to the blood clots.

Riboksina general effect is to increase the contractility of the myocardium, its more complete relaxation during diastole and increased stroke volume. In addition, under the influence of Riboxin improved recovery of the heart muscle after myocardial infarction. This action helps to prevent the development of chronic cardiovascular disease and the development of thromboembolism. Also improved regeneration of gastric mucosa after erosive and ulcerative lesions and liver condition in all its diseases.

Indications for use

Riboxinum used primarily in cardiovascular diseases. So, it is widely used in coronary heart disease (CHD). This disease is characterized by impaired coronary circulation due to the fact that the clearance reduces atherosclerotic plaques of the coronary arteries. An extreme manifestation of coronary heart disease is a heart attack - necrosis of myocardial tissue. Under the action riboksina it improves myocardial metabolism, which in turn increases the tolerability of myocardial hypoxia, that is, prevents the development of myocardial infarction. And if you still infakrkt infarction occurred Riboxinum contributes to the rapid recovery of heart function.

In addition, Riboxinum prescribed for heart defects (congenital or acquired), inflammatory and metabolic disorders in the myocardium (myocarditis and myocardial), as well as adults, in developing on the background of cardiac glycosides.

Will Riboxinum in acute and chronic hepatitis, liver cirrhosis of any origin, fatty liver and other diseases. Under the influence of Riboxin improved function of hepatocytes - the liver cells.

In gastric ulcer and duodenal ulcer Riboxinum prevents exacerbation and contributes to a more rapid conclusion.

Used Riboxinum well as urokoproporfirii - cutaneous porphyria, is characterized by impaired metabolism of porphyrins, which are being postponed in the skin to cause sensitization to the sun, and increased sensitivity to mechanical stimulation. The disease is dysfunction of the liver enzyme responsible for the synthesis and exchange of porphyrins. To improve the condition of the liver cells, and thus the condition of these patients could use Riboxin.

Under the influence riboksina faster the healing of radiation burns, and there is no reduction in the number of leukocytes in the blood. With open-angle glaucoma Open-angle glaucoma - occurs often goes unnoticed   Riboxinum improves vision.

Side effects and contraindications Riboxin for its reception

Riboxinum generally well tolerated, but sometimes in the background of his admission there are attacks of palpitations, there is redness and itching of the skin, increased uric acid in the blood and increase gout. And possible allergic reactions.

Application Riboxin contraindicated in gout, elevated levels of uric acid in the blood, intolerance of simple sugars (glucose, fructose, sucrose), as well as hypersensitive to the components of the drug. Riboxinum in vials is contraindicated in pregnancy, breast- Breastfeeding - a personal choice   chest and under the age of 18 years - the use of the drug in these patient groups has not been confirmed by clinical studies.

With careful use Riboxinum with severe renal impairment and diabetes.

Riboxinum improves metabolism Improves metabolism and losing weight without dieting   in cells, and thus the condition of an organ as a whole.

Galina Romanenko

The symptoms of sciatica may vary in its severity. Someone this disease can occur with intense and exhausting unbearable pain, and some - unexpressed pain, but over time the symptoms may get worse.

Typically, the pain of sciatica is most often observed on one side. And depending on the level of the nerve roots of the lumbar plexus, the pain can be in the buttocks and give to the legs, feet or fingers. In addition to pain is frequently observed as numbness or tingling.

Back pain may be present along with the pain in his leg, but usually the pain in my leg is much more intense than the pain.

The most common symptoms of sciatica

• Back pain, if it occurs, less severe than the pain in his leg.
• Constant pain there is only one side of the buttocks, legs, or feet, but rarely affects both sides of the body.
• The pain occurs in the lower back or in the buttocks and hands down the back of the thigh, shin and foot.
• Pain is reduced when the patient takes a horizontal position, or walking, but worsens while standing or sitting.
• Burning or tingling in the lower leg.
• Weakness, numbness or difficulty of movement in the leg.
• Constant sharp pain on the back of the leg.
• Severe or shooting pain in the leg, hindering the standing or walking.

Depending on the level of the nerve root pain with sciatica can give to the foot and toes.

Symptoms of inflammation for each root of the sciatic nerve

We have two sciatic nerve root in the lumbar spine (L4 and L5) and three spine in sacral (S1, S2 and S3). These five nerve roots forming the sciatic nerve The sciatic nerve: how to avoid the excruciating pain? , A branch of which go up and provide motor and sensory functions of the lower leg and foot.

Symptoms of sciatica depends on what level was the defeat of the nerve roots, ie, a nerve root damage. For example:

• Symptoms of neuralgia in the defeat L4 nerve root is usually applied to the thigh. Patients may feel weak at straightening the legs, and perhaps worsening knee-jerk.
• Symptoms of neuralgia nerve L5 nerve root lesion may extend to the big toe and ankle (so-called "hanging foot"). Patients may feel pain or numbness in the upper part of the foot, particularly between the thumb and the second toe.
• Symptoms of neuralgia S1 nerve root lesion spread to the outside of the foot and can give to the little finger or other toes. Patients may experience weakness when lifting the foot or trying to stand on tiptoe. Achilles tendon reflex may also be weakened.

Since inflammation can affect more than one nerve root, many patients experience symptoms combined. Most patients with leg pain may be aggravated by coughing, sneezing, laughing. In addition to the pain of sciatica Sciatica (sciatica) - is not a disease   notes, and muscle weakness.

Symptoms that require immediate attention

In rare cases rapidly increases the symptoms of neuralgia of the sciatic nerve Sciatica - and if it will affect the spine?   may require immediate surgical intervention. The following symptoms indicate the need for immediate medical attention:

• symptoms of inflammation, which will eventually increase, rather than decrease, which may indicate possible nerve damage, especially if the symptoms are progressive neurological in nature (eg, weakness);
• Symptoms, which are distributed on both legs (the so-called "two-sided sciatica"), and are accompanied by bladder dysfunction Urinary bladder - structure and function   or bowel, which may indicate cauda equina syndrome. This syndrome occurs in the case of compression (compression of) the nerve roots, while there is dysfunction of the lower extremities and bladder. Cauda equina syndrome can lead to urinary incontinence and temporary paralysis of the legs. Cauda equina syndrome is observed in 2% of cases of disc herniation of the lumbar spine.

Patients should seek immediate medical attention if they experience any of these symptoms.