Any drugs which can not be combined with the use of other drugs or foods that have a similar effect. For example, during the course of treatment can not be used nimesilom alcohol, because both nimesil, and alcohol have hepatotoxic (liver-destroying cells) properties.

Hepatotoxic effects of alcohol

Hepatotoxicity have many poisons, drugs and products. Drinking among them a special place. The reason for its toxicity to liver cells is that it decomposes in the body to metabolites (metabolic products) is in the liver. At the same time most of the alcohol is decomposed into acetaldehyde, which damages the liver cells - hepatocytes. The liver cells are damaged and die off instead grows connective tissue. When thus will replace a significant portion of the hepatocyte cells of connective tissue, the reduced function of the liver. In this case speak of alcoholic cirrhosis.

Sometimes alcohol affects the liver differently. Since alcohol itself is a source of energy, fatty acids, which normally decompose in the liver followed by the release of energy, and makes it unnecessary to accumulate in the liver. This gradually leads to fatty liver - fatty liver, in which also impairs the function of the liver. Drinking alcohol or any other hepatotoxic substances can translate steatosis in hepatitis Hepatitis - the scourge of our time Which then also pass in the alcoholic cirrhosis.

Toxic liver changes may occur in mild, moderate and severe forms. In mild form such changes may not be noticed, which is very dangerous, as any further use of hepatotoxic substances could lead to a sharp deterioration.

At moderate pain in the right upper quadrant, jaundice of varying intensity, during examination revealed liver dysfunction. In such a case diagnosed acute toxic hepatitis Toxic hepatitis - the impact of harmful substances on the liver .

In severe the patient has severe abdominal pain Abdominal pain: Types and Symptoms , Vomiting with blood, his condition is getting worse by the hour due to massive necrosis (dying off) liver cells. If time does not help, the patient goes into a coma and may die.

Can I drink alcohol during treatment nimesilom

Of course, it is impossible. Simultaneous exposure to two substances hepatotoxic very dangerous, above all, unpredictable effects on the body. Much depends on the individual, including the inherited characteristics of an organism. After alcoholic cirrhosis suffer not all patients with chronic alcoholism, but no more than 15%.

Of course, nimesil has no pronounced hepatotoxicity, however, this action is, which is reflected in the instructions in the form of possible side effects - abnormal liver function and even hepatitis. At the same time such side effects are not all the patients, and in very rare cases. This also indicates that a person has a predisposition to such changes of the liver, most likely in the form of some failure or enzymatic metabolic characteristics.

Now imagine that the liver of the patient at the same time there are two factors hepatotoxic. This can lead to instant very severe liver disease - the so-called fulminant hepatitis. Since most people do not know the genetic characteristics of their metabolism Metabolism: The basis of life of all living things It is better not to risk and not to drink alcohol during treatment nimesilom.

Reflected whether the prohibition of alcohol in the treatment of nimesilom instructions

An outright ban on the simultaneous reception of Nimes and alcohol in the instruction no. This is surprising for such a large pharmaceutical companies such as Berlin-Chemie.

But if you carefully read the instructions, you can see that nimesil contraindicated in hepatic dysfunction and chronic alcoholism (where is the guarantee that in patients with chronic alcoholism no hidden liver damage). In addition, the side effects of the drug have a point that there were cases of fulminant hepatitis in patients receiving nimesil. How is it possible to combine the reception albeit not very strong hepatotoxic drug nimesil alcohol, which has a selective and very strong toxic effect on the liver cells?

How to take nimesil

Nimesil take one sachet of 100 mg twice daily after meals. The contents of the sachet are poured with a cup of water (about 100 mL). Divorced nimesil immediately taken, it can not be stored. The course of treatment should last no more than 15 days.

About taking alcohol during treatment nimesilom not out of the question.

Galina Romanenko

Costochondritis - an inflammation of the cartilage that connects the ribs to the breastbone (located in the edge-sternal junction). The pain of this disorder can be similar to symptoms of a heart attack Symptoms of heart attack in women - do not miss time   and some other states. Costochondritis, not accompanied by swelling, called Tietze's syndrome.

Symptoms

Frequently costochondritis causes pain and increased sensitivity, which usually appears on the left side of the sternum, it affects more than one rib and amplified when the patient breathing deeply or coughs. Because these symptoms may be signs of a heart attack Heart disease and heart attacks: that every woman should know , When they occur, and it is necessary to address urgently to the doctor.

Causes

In most cases kostohondrita no obvious reasons. Sometimes it is caused by the impact of the following factors:

• Injury. The blow to the chest can cause kostohondrita.
• Physical exertion. Lifting heavy loads and very intense exercise, and coughing associated with the development kostohondrita.
• Arthritis. Some patients costochondritis caused by specific problems, such as osteoarthritis, rheumatoid arthritis Arthritis - a variety of forms and complications Or ankylosing spondylitis.
• Infection of the joint. Costosternal joint can be infected by viruses, bacteria and fungal organisms. For example, it happens in syphilis, tuberculosis, aspergillosis.
• Tumors. Cancerous and non-cancerous tumors can also cause costochondritis.

Risk factors

Costochondritis is most common in women in people older than forty years.

Diagnostics

During the examination the doctor feels the area edge-sternal junction to detect swelling and increased sensitivity of the area. It may also move the patient's arm in a certain way in an attempt to cause the appearance of symptoms.

Since there is no lab tests and medical imaging, by which it would be possible to diagnose costochondritis, during the diagnostic tests are performed to help rule out other possible causes of symptoms for which the patient complains. Among such tests - X-ray, electrocardiogram, and so on.

Treatment

Typically costochondritis extends itself, although in some cases, symptoms may persist for several months or even longer. The objective of treatment - to relieve these symptoms.

Medications

• OTC nonsteroidal anti-inflammatory drugs (NSAIDs) most often recommended to relieve pain and reduce inflammation in the costochondritis. In some cases, the doctor prescribes receiving prescription NSAIDs.
• Opioid painkillers. In very severe pain doctor may prescribe medications containing codeine, such as hydrocodone (Vicodin, Lortab, and others) or oxycodone (Percocet, Roxilox and others). These drugs can cause dependence, so long-term treatment should be minimal.
• Antidepressants. Tricyclic antidepressants such as amitriptyline, often used to control chronic pain - especially if it does not give a patient to sleep at night.
• Anticonvulsant drugs. The cure for epilepsy Epilepsy - a sacred disease   Gabapentin has been used successfully for chronic pain, including those caused by kostohondritom.

Treatment

• Stretching exercises can be very effective in costochondritis. Which exercise suitable in each case, to decide a physiotherapist.
• Stimulation of the nerve. During the procedure, called transcutaneous electrical nerve stimulation, using a special device under the skin sends a weak electrical current, which can disrupt or mask pain signals, not allowing them to enter the brain.

If the above treatments do not help the physician can offer to inject anesthetic agent and a corticosteroid in a joint, which is a source of pain.

At home, you can relieve the symptoms kostohondrita applying to a portion of ice or a heating pad, as well as avoiding the loads that increase the pain.

Prevention

Carrying heavy bags, especially on one shoulder may be a direct or indirect cause of kostohondrita. Teach your child to wear a school bag, and themselves avoid too heavy bags.

Avoid exercises that cause pain similar to the symptom kostohondrita. Frequent repetition of such exercises can actually cause the development kostohondrita.