Analogs of Xenical: Fighting obesity

December 18, 2011

  • Analogs of Xenical: Fighting obesity
  • Effects of orlistat
  • Alai (Alli)

 Xenical analogues
 There are many drugs for weight loss, which helps to reduce body weight. Use should be with caution and only after consulting with your doctor to struggle with excess weight does not harm health.



International nonproprietary name: Orlistat

Trade names: Alli, Xenical.

Orlistat is used to treat obesity in adults who are overweight. It may also be designated to reduce the risk of weight recovery after previous weight loss. It is used in conjunction with a diet low in calories and low in fat. Orlistat - inhibitor of gastrointestinal lipases. It acts by blocking the absorption of fat from the diet.

Orlistat should not be used by those who:

  • are allergic to any ingredient Orlistat
  • No excess weight
  • problems with the gallbladder, bile (eg, cholestasis), or problems with absorbing food (malabsorption)

Before using Orlistat you must inform your doctor about the following conditions:

  • pregnant, planning to become pregnant or breast-feeding Breastfeeding - a personal choice  Breastfeeding - a personal choice
  • taking any prescription or nonprescription medicine, herbal medicines or dietary supplements
  • allergies to medicines, foods or other substances
  • eating disorders (such as anorexia Anorexia nervosa - symptoms and effects on the body  Anorexia nervosa - symptoms and effects on the body
 , Bulimia)
  • history - diseases of the gallbladder, liver, pancreas, thyroid disease Thyroid disease - women at risk  Thyroid disease - women at risk
 Diabetes, kidney stones Kidney stones: identify and treat  Kidney stones: identify and treat
  • medication for diabetes and thyroid disease, or taking any other medications for weight loss, receiving cyclosporine
  • history - organ transplantation

Some drugs may react with orlistat. You must tell your doctor about taking any other medicines, especially the following:

  • anticoagulants (eg, warfarin) because when taking orlistat mozhnt increase the risk of bleeding
  • amiodarone, cyclosporine, or thyroid hormones (e.g., levothyroxine) because their effectiveness may be reduced due to the orlistat

The list of possible interactions may be incomplete. You should ask your doctor whether Orlistat interact with other medications taken. Before you start or stop taking any medication or change the dose, you should consult with your doctor.


How to take Orlistat

Take orlistat should be in accordance with the instructions of the doctor. Read the summary to clarify the dosage.

  • The packaging of the drug have a table height and weight ratio. You can think about the need to orlistat, if the weight exceeds the figures corresponding to the growth of the patient. If you have any questions - you need to ask their doctor or pharmacist.
  • Take Orlistat should be taken with each meal. Do not take more than three capsules a day.
  • If a meal is missed or contains no fat meal, do not take a dose of Orlistat.
  • Orlistat can reduce the absorption of vitamins. While receiving orlistat need to take a multivitamin at bedtime.
  • If a patient takes thyroid hormones (eg, levothyroxine), it should be taken four hours before or after taking orlistat. If you have any questions you need to ask their doctor.
  • If the patient also receives cyclosporin, he must take his two hours before or after administration of orlistat. Before taking orlistat with cyclosporine, should consult a doctor.
  • If the patient has missed a dose of orlistat reception, he should take it as soon as remembered about it, and continue to take the medicine as prescribed by your doctor, or as specified in the summary.

Any questions regarding the use of orlistat should ask your doctor.

Analogs Meridia - produced by different pharmaceutical companies

May 6, 2012

 analogs meridia
 Various pharmaceutical companies produce several analogues of the drug Meridia. The main active ingredient in all of these drugs are sibutramine - a drug that suppresses hunger by affecting the brain.

 Analogs Meridia - produced by different pharmaceutical companies

Sibutramine and its analogues

Sibutramine - a drug for the treatment of obesity of the central action. It prevents the spread of nerve impulses by inhibiting the process of recapturing some of the neurotransmitters - substances through which nerve impulses are transmitted. Simultaneously sibutramine increases energy consumption by inhibiting the reflex slowing metabolism Metabolism: The basis of life of all living things  Metabolism: The basis of life of all living things
   against falling weight. Improved by the action of this drug is also fat and carbohydrate metabolism.

Sibutramine is manufactured by different pharmaceutical companies under the following brand names:

  • Meridia Meridia - gives a sense of satiety  Meridia - gives a sense of satiety
   (Abbott GmbH, Germany);
  • lindaksa (Zentiva, Czech Republic);
  • Goldline (Laboratory of Ranbaxy, India);
  • Slim (Torrent Pharmaceuticals Ltd., India);
  • Reduxine (OOO Avista, Russia).

These drugs are recommended for use only when all other treatments for obesity have no effect. This treatment should be comprehensive and take place under the supervision of a physician, an endocrinologist with practical experience in the treatment of obesity. The complex treatment includes diet, increasing physical activity, changing the whole way of life. All this contributes to the formation of persistent changes in eating habits and lifestyle, which are needed to preserve the achieved body weight after the abolition of drugs.

 Analogs Meridia - produced by different pharmaceutical companies

The original and reproduced drugs

Any drug is available for the first time some of the pharmaceutical company that conducts all the necessary laboratory and clinical trials, drug records under some international non-proprietary name (INN), and obtained a patent for its manufacture a certain number of years. The firm gives to the drug trade (under brand) name and selling it. Such a preparation is called the original or brand. Until the patent has expired, no other firm to produce the same drug may not, but after the expiration of this period other firms can use this formula and to produce similar drugs. They all have the same INN and various trade names, manufactured by invented. These drugs are called generics.

Are there any differences between brands and generics? It would seem that there should not be, but experience shows that there are often significant. Brands usually produce big pharmaceutical company with a good reputation, which has great significance for them. Therefore, they use high quality raw material, have equipment that meets international requirements (system GMP) and comply with all technology.

Generics also produce smaller firms that do not always hold all the necessary requirements. Although, of course, and generics can be as good as brands - all individually. In the production of generics firms often save on the raw material and buy it in Asian countries, where a lack of quality control over their production. The instructions to these drugs, of course, does not reflect all the nuances, so it is difficult to directly determine the quality is generic or not.

 Analogs Meridia - produced by different pharmaceutical companies

Brands and generic sibutramine

The original drug or brand in this case is the drug Meridia, which produces the German pharmaceutical company Abbott GmbH. This drug has successfully passed all clinical trials where it has been proven safe. Meridia is done on their own original technology Abbott in accordance with international quality standards GMP. The starting material (raw materials) for the manufacture of the drug (sibutramine hydrochloride) used only the highest purity and European production.

Therefore, it is meridia quality standard for all other preparations in which the active ingredient is sibutramine Sibutramine - effective but not safe  Sibutramine - effective but not safe
 . All generic drugs sibutramine, which are present in the Russian market, fully replicate the original drug Meridia. Lindaksa, Goldline, Sliema and Reduxine also available in capsules, at the same dosage. Instructions to these drugs completely copied instructions in Merida.

Different prices for all of these drugs. Thus, the average price of Meridia, depending on the dosage and number of tablets in a package of 2, 5 to 4 thousand rubles and more. Lindaksa (15 mg, 90 pieces) - 5000 rubles Reduxine (15 mg 30 pieces) - 1300 rubles, Goldline - (15 mg 30 pieces) - about 950 rubles.

Which of these medicines to choose the best tell a doctor who has experience in the destination of such products.

Galina Romanenko

Article Tags:
  • Meridia