Contraindications and precautions

Safety measures

Xenical should not be used in patients who have had a hypersensitivity reaction to any of the active or the inactive ingredients of the formulation. Cholecystokinin stimulates contraction of the gallbladder after his release from the mucosa of the upper small intestine, which depends on the presence of free fatty acids in the intestinal lumen. Postprandial cholecystokinin concentration in plasma decreased after administration of multiple doses of Xenical in 2 of 4 trials.

Although no decrease gallbladder contraction were noted in healthy people with normal weight during a randomized, double-blind, placebo- Placebo - an effective tool for self-hypnosis -controlled crossover study following the administration of a single dose of Xenical, a long-term effect on gallstones Gall bladder: structure and function   It has not been determined. Xenical is contraindicated for use in patients with cholestasis, which may be present in cases of gallbladder disease.

There have been very rare cases of elevated liver enzymes, increased alkaline phosphatase, and extremely rare cases of hepatitis. It has not been established a causal relationship, or the physiological and pathological mechanisms between hepatitis and treatment ksenikalom.

Absolute contraindications

• cholestasia
• malabsorption
• anorexia nervosa
• lactation
• bulimia nervosa
• Children age
• advanced age
• gallbladder disease
• hepatitis Hepatitis - the scourge of our time
• hypothyroidism
• nephrolithiasis
• obesity
• pregnancy

Xenical reduces the absorption of nutrients and vitamins. Thus, Xenical is contraindicated for use in patients with chronic malabsorption syndrome. Because Xenical can interfere with absorption of fat-soluble vitamins, all patients should take a daily multivitamin Multivitamins - how dangerous overdose? Which contain vitamins A, D, E, K and beta carotene; they must be taken at least 2 hours before or after administration of Xenical.

Relative contraindications

Xenical is contraindicated in respect to organic causes of obesity, such as hypothyroidism. Causes of obesity, in addition to the excess supply, should be excluded before prescribing Xenical.

Because Xenical can lead to weight loss, there is an opportunity for abuse on the part of certain groups of patients, including those with anorexia nervosa or bulimia. These patients should not use Xenical.

Because treatment can occur ksenikalom increase in urinary oxalate. Caution must be exercised in patients with a history of kidney stones with calcium oxalate stones or hyperoxaluria.

Drug Interactions

Cases of reducing prothrombin, increased INR and unbalanced anticoagulant treatment, which resulted in changed hemostatic indices, have been reported in patients receiving anticoagulants concurrently with ksenikalom.

Xenical should not be taken lactating women, so it is not known whether Xenical is absorbed into human milk.

Xenical is not recommended for use during pregnancy as there were no adequate and well-controlled studies in pregnant women. Studies in animals at doses up to 800 mg / kg / day showed no Xenical teratogenic or embryotoxic effect. However, animal studies are not always predictive of human response results.

Xenical for children and the elderly

In pediatrics Xenical should be used with caution, as the safety and efficacy of Xenical has not been evaluated in children 12 years of age. According to the manufacturer, the use in obese twelve-sixteen year olds supported by studies in adults and additional data from pyatidesyatichetyrehnedelnogo study the safety and effectiveness conducted among obese adolescents.

Insufficient numbers of patients aged 65 and older participated in clinical trials to determine the response of the patients. Therefore Xenical in the elderly must be used with caution.

Reviews of doctors

There are many drugs on the blockers and fat metabolism boosters Metabolism: The basis of life of all living things   up pills, which suppress hunger and appetite, from which everyone can choose something for themselves. Most often, the producers of such funds promise that we can get maximum results with minimum effort.

There is an anti-obesity drug, which should be taken only by prescription - Xenical (orlistat). Orlistat is also now exist in the form of diet pills Alli. Xenical blocks the action of lipase, an enzyme that digests the fats in the intestines, and blocks about 30 percent fat, which is ingested with food. As a result, the body loses about a third of the calories contained in the fat, so weight loss occurs. If the fat is not absorbed in the intestine, it is eliminated from the body with a chair.

Since fat contains approximately twice as many calories per serving than the proteins and carbohydrates via Xenical person can expect to lose a significant amount of calories consumed initially losing weight at a speed to 0 -1 5 kg per week. Studies prolonged use Xenical show that those who can stand for Xenical intake, the total weight loss is likely to be approximately 2, 5 - 5 kg more than diet only.

The good news is that, unlike many diet pills that can be bought without a prescription, Xenical is clinically proven medication that helps people lose weight and usually gets the support of the majority of doctors.

Experts believe that this is a very good drug for use in patients who are obese and meet certain medical criteria. Many clinical studies have examined the effectiveness of Xenical in the treatment of obesity and found that he was successful in helping obese people lose weight How to lose weight - basic principles .

Yet many experts believe that the success in the treatment of obesity is not only a result of the active ingredients of Xenical, but also the result of the fact that patients follow the advice on lifestyle they lead. People who are prescribed Xenical should closely follow the recommendations of your doctor. They receive advice on diet and exercise that will help them to achieve the desired effect.

Side effects

In clinical practice, some doctors have reported that the successful use of Xenical is found in 1 out of 5 people. These doctors say that almost everyone who tries to take it, even with the most careful advice about the best ways to avoid the embarrassing side effects, can barely tolerate the drug. The most important of these inconveniences - uncontrollable liquid bowel movements.

Those who take Xenical, also need to be borne in mind that it can cause a deficiency of certain vitamins, especially vitamins A, D, E and K. For this reason, it is recommended to take a multivitamin Multivitamins - how dangerous overdose?   a few hours before or after taking Xenical. This medicine may interfere with the action of certain medications, such as thyroid hormones Thyroid hormones: mechanism of action and physiological effects And it can not be used by people with various diseases of the liver or intestines.

The verdict of doctors

Certainly, Xenical takes place in the treatment of obesity. Patients who believe that they are suitable candidates to try this drug, you should seek the advice of your doctor. You could also try a pill for weight loss Alli. These drugs are subjected to serious research, and their effectiveness is clinically confirmed.

Lose weight need to safely and wisely

Just as vitamin supplements does not compensate for a diet that does not contain fruit or vegetable, it is impossible to expect that any medication for weight loss compensates for high calorie diet and a sedentary lifestyle!

To lose weight safely and sensibly, you must first give up the unhealthy diet and lack of exercise, which helped overweight. If you decide to long-term changes in your diet and lifestyle, you will not have to resort to emergency assistance.

Before you decide to take pills, doctors recommend at least two weeks a diet with a low-calorie and low-fat diet that is recommended by most manufacturers of diet pills. Many people believe that by making some relatively minor changes in dietary habits, they embarked on the path to sustainable weight loss.

Only the patient with his doctor can decide which treatment is best for him. Comments made here are not intended to refer the patient to the treatment of any condition or disease.