The instructions to tsetrinu developed by the manufacturer to combine the reception tsetrina with alcohol is not recommended, despite the fact that at the reception tsetrina at therapeutic doses, alcohol did not potentiate (not increases) its effect. So why are they combine desirable?

How does the human body tsetrin

Tsetrin is an antihistamine drug, a blocker of H1-histamine receptors. Histamine - a biologically active substance which participates in many vital processes in the body. However, histamine is known mainly due to the fact that is directly involved in the development of allergic reactions.

Antihistamines block the flow of histamine on the H1 receptors located in the cells of tissues, so it is not delivered to the membranes of cells and exerts its action not. The first generation antihistamines have been able to easily penetrate into the tissues of the brain (to overcome the blood-brain barrier), so this group of drugs causes marked sedative effect (diphenhydramine, suprastin, pipolfen).

Tsetrin relates to the third generation antihistamines and has a selective effect on the histamine H1-receptor, without penetrating into the brain, if the drug is taken in therapeutic doses. But tsetrin affects the majority of patients. But some patients feel the side effects of the drug in the form of the inhibitory effects on the central nervous system (CNS): sleepiness, confusion or agitation, headaches and dizziness Dizziness - if the ground is slipping from under his feet . The same phenomenon appears in overdose tsetrina.

In tsetrina there are other side effects: it causes irritation of the gastrointestinal tract, which appears decreased appetite, nausea, sometimes vomiting, diarrhea, transient abdominal pain and dry mouth.

Sometimes these side effects are expressed slightly and the patient does not notice them. It can safely drive a car or do other activities that require high concentration and coordination. So why from time to time do not take alcoholic drinks, why manufacturers tsetrina (Indian pharmaceutical company Dr. Radish Laboratories Ltd) is not recommended to combine intake of the drug with alcohol?

How does alcohol on the human body

The effect of alcohol on the human body two-phase: first, it suppresses the inhibitory effect of the central nervous system, causing excitement, and then, on the contrary, strongly inhibits the work of the CNS. The first phase takes place characteristic of intoxication disinhibition - the man has no control over their actions. He can say and do things that would never have allowed himself sober. At the same time quickens the number of respiratory movements, reduced blood pressure Blood pressure - dangerous if his swing? .

In the second phase, which develops when a person continues to drink alcohol, there comes a pronounced inhibition of the central nervous system: there is lethargy and sleepiness, and at the same time blocks the action of all the centers of internal organs located in the brain. Special danger alcohol poses to the respiratory center, whose activities are actively suppressed. Therefore, the alcohol overdose death of a man often occurs from respiratory failure.

It has alcohol (especially strong) irritant effect on the gastrointestinal tract.

Whether during a reception combining tsetrina and alcohol happen any emergency situation?

Theoretically it is possible, if tsetrin has side effects on the central nervous system, alcohol is his efforts that could lead to respiratory arrest. But any information about this kind of action today does not exist. Perhaps this is due to the fact that tsetrin - is a relatively new drug and has not "tested" by all segments of the population, including in combination with alcohol.

But well studied combination of alcohol with Dimedrolum (first generation antihistamine). This combination causes the psychosis with delusions Brad - not only crazy   and hallucinations and threatens to stop breathing Stop breathing (apnea) during sleep - upper airway obstruction .

The total negative impact tsetrina combination of alcohol on the body

The combination of alcohol with tsetrinom can not but have a negative impact on the patient's body. When receiving the alcohol formed in the body of toxic metabolic products, which stimulate the development of allergic disorders, including exacerbation of chronic allergic diseases, which takes about tsetrin. The negative effect of such a combination may exert on the gastrointestinal tract.

So whether or not to take alcohol to people who receive treatment for allergic diseases? It may be worthwhile to pay attention to their health and well perform all the prescription?

Galina Romanenko

Tavegil - it is one of the oldest anti-allergic drugs, which has both advantages and disadvantages. The disadvantage is its side effects, which result in a number of contraindications to the use of this drug.

The principle of operation Tavegilum

Action Tavegilum based on the fact that it does not allow the appearance of the hearth allergy histamine blocker being its H1 receptor. If an allergic reaction has started, the lack of new revenues of histamine leads to its rapid decay.

Histamine - a biologically active substance which participates in many biochemical reactions, including it is a major cause of allergy symptoms as itching, increased permeability of small blood vessels (capillaries), which leads to the appearance of tissue edema and exudation - liquid secretions (e.g. from the nose). Severe allergic reaction, such as anaphylactic shock accompanied by a sharp drop in blood pressure.

Tavegil available in dosage forms for oral administration (tablets and syrup) and as a solution for injection, it can be used in all types of allergic reactions and many allergic diseases.

But tavegil has a lot of side effects, so you can not use it all. Absolute contraindication for use Tavegilum is the increased sensitivity to the patient.

Contraindications for use Tavegilum the central nervous system

Tavegil (like all first-generation antihistamines) through the bloodstream easily enters the central nervous system (CNS). Therefore, they have traditionally cause such contraindications to the simultaneous use of them with drugs that have an active effect on the central nervous system. But an absolute contraindication for receiving Tavegilum a simultaneous reception of one of the types of antidepressants - MAO inhibitors.

In addition, it is not necessary to combine the reception Tavegilum with taking sleeping pills, sedatives or alcohol.

Contraindications for use Tavegilum from respiratory

All antihistamines help to reduce exudation, tavegil is no exception. In the treatment of diseases of the bronchi and lungs are always trying to translate a dry cough Dry cough - whether to worry about it?   in the wet, that is, cause increased mucus exudation. Admission Tavegilum reduces exudation and makes more viscous mucus that is not conducive to recovery.

Especially dangerous is the use Tavegilum bronchial asthma, bronchospasm attacks in which the end of a viscous glassy mucus release. The application in this case Tavegilum may violate patency of the bronchi and provoking a new attack of bronchospasm.

Tavegil during pregnancy, breast-feeding and children

Tavegil in any dosage form is contraindicated for the treatment of children under one year. And as it stands with human milk, it can not accept and nursing mothers.

Harder with Tavegilum during pregnancy. Absolute contraindications for its reception is not, however, recommended to use it with great caution and only in those cases where the benefit to the mother's body is much greater than the potential risk to the fetus.

In some cases, tavegil should be taken with caution

Some diseases require the appointment Tavegilum with extreme caution. Such diseases include, for example, angle-closure glaucoma Glaucoma - a perspective possible blindness In which the intraocular pressure can rise very quickly on any extension of the pupil, for example, from taking drugs, including Tavegilum. At the same time patients suddenly appears a severe headache and blurred vision.

There are relative contraindications for receiving Tavegilum and from the gastrointestinal tract. This various disorders passage of stomach contents to the duodenum, such as stenosis (narrowing) of the opening in place of the transition.

Precautions should apply Tavegilum well as violations of urination, e.g., an increase in prostate cancer (if it squeezes bladder) or when there is patency of the bladder neck Urinary bladder - structure and function .

In diseases of the heart and blood vessels, including high blood pressure, and improve thyroid function The thyroid gland - is responsible for your hormones Which may be accompanied by changes of the cardiovascular system, tavegil also relative contraindications and appoint a doctor.

Tavegilum - is an effective anti-allergic drug, which, however, has both absolute and relative contraindications for use.

Galina Romanenko