Tsetrin - it is anti-allergic drug that produces an Indian pharmaceutical company Dr. Reddic Laboratories Ltd. Used tsetrin in various allergic diseases, the duration of action of the drug is able to receive it once a day.

The mechanism of action tsetrina

Tsetrin (INN - cetirizine) refers to a group of drugs - blockers H1-receptor antagonists of the third generation and is available in tablets of 10 mg. Mediator (a substance with which the excitation is transmitted in cells) Histamine is a basic substance causing allergic reactions. On the cell surface of various organs and tissues have specific molecule - receptor sensitive to histamine, which are called H1-receptors (H2-receptors are located in the stomach wall, through which affect histamine secretion and gastric acidity).

Tsetrin selectively blocking histamine H1 retseptry, without affecting the receptors of other mediators, which significantly reduces the possibility of side effects of this drug. In the recommended therapeutic doses tsetrin does not penetrate into the tissue of the brain (ie, it does not overcome the blood-brain barrier) and has a calming effect on the central nervous system. It is effective, as in the beginning of allergic reactions by reducing the migration of eosinophils (leukocyte species responsible for the allergic reaction) and in its later stages (by inhibiting the action of histamine and other biologically active substances involved in allergic reactions).

When administered tsetrin rapidly absorbed into the blood and into the tissue, the presence in the stomach and intestines to food has no significant influence drug absorption. The maximum therapeutic effect is reached within an hour after administration and lasts for days. Then, most of the tsetrina excreted in the urine in unchanged form, as part of the splits in the liver and excreted then urine and feces.

Indications and contraindications for appointment

Application tsetrina shown in various allergic diseases and processes. It is prescribed for the treatment and prevention of various diseases and allergic reactions in children over six years and Adults:

• in chronic allergic rhinitis, including hay fever when - allergic rhinitis caused by pollen of flowering plants;
• with allergic conjunctivitis, both year-round and seasonal, are a manifestation of hay fever;
• itching of the skin of different origin;
• insect bites, accompanied by edema Prevention and treatment of edema - it is important to understand the root cause , Burning and itching;
• hives, including the chronic course of the disease;
• when angioedema or angioedema - swelling of the subcutaneous tissue, which is dangerous because it can move to the soft tissues of the throat and cause breathing disorders.

Adult patients tsetrin administered one tablet (10 mg) once a day. Babies after six years prescribed daily dose of the same, but divide it into two doses of 5 mg. Tablets advisable not to chew and drink some water.

Contraindications tsetrina intake during pregnancy, breast- Breastfeeding - a personal choice   feeding, the age of six years and in case of hypersensitivity of the patient to the drug. With care and reducing the dose twice tsetrin prescribed for severe kidney disease in violation of their functions.

Side effects

Tsetrin nontoxic drug, it gives little side effects. This enabled to allow the sale of the drug in pharmacies without a prescription, that is, its use in some cases short time allowed without a prescription.

But sometimes side effects do happen, and patients should know about them:

• the central nervous system - may sometimes appear lethargy, weakness, decreased performance, drowsiness; but in some cases, instead of lethargy to develop motor and emotional agitation, insomnia; It can often be headaches and dizziness Dizziness - if the ground is slipping from under his feet ;
• from the gastrointestinal tract - dry mouth, nausea, vomiting, diarrhea, bloating, abdominal pain Abdominal pain: Types and Symptoms ;
• allergic reactions such as itchy skin rash and angioedema - very rare.

Tsetrin a blocker N1- receptor antagonists of the third generation, so it is devoid of such shortcomings, drowsiness, lethargy, impaired attention and coordination. But in some patients it may have such an effect, so to drive vehicles and other activities that require attention and coordination of movements, should be treated with caution.

Tsetrin - a drug that you can have in your home medicine cabinet.

Galina Romanenko

Tablets Erius help get rid of the symptoms of allergic diseases, such as nasal congestion, sneezing, itchy nose and watery eyes associated with pollen blossom season or year-round allergies, allergic skin diseases Skin diseases - what to do when violated the basic functions of the skin   and allergic reactions.

Histamine and antihistamines drugs

Any allergic reaction is accompanied by the release of large amounts of histamine - the active substance, which is a neurotransmitter (a substance through which nerve impulses are transmitted from neuron to neuron). When there is no allergic reaction, histamine is in a bound state, and with the beginning of an allergic reaction, it is released to affect the sensitivity to the receptors, which leads to the different manifestations of allergy.

In humans, there are two kinds of receptors sensitive to histamine H1 receptors are responsible for the implementation of the vascular effects of histamine (dilation of capillaries, tissue edema, serous discharge, and so on) and H2 receptors, which are responsible for the secretion of gastric juice.

Antihistamine drugs inhibit histamine receptor sensitivity and output of histamine into the bloodstream. They also come in two flavors: blockers H1 - receptor (rented tissue swelling, itching, and so on) and the H2 receptor (reduced secretion of gastric juice.

Action tablets Erius on the body

Aerius is a blocker of peripheral H1-histamine receptors. It blocks the action of histamine. It is an antihistamine of the latest generation, which is characterized by high efficiency, duration of action, and nearly complete absence of side effects. At therapeutic doses erius causes lethargy and sleepiness while taking this drug, you can even drive a car.

Aerius is especially effective in the early development of an allergic reaction: it is able to completely prevent the development of edema Prevention and treatment of edema - it is important to understand the root cause , Itching, and other manifestations of allergic reactions. If an allergic reaction in full swing, Aerius is blocking the release of histamine and reduces its manifestations.

When the tablets are administered drug is rapidly absorbed in the intestine into the blood, and thence into the tissue begins to act after 30 minutes and is active during the day. In the central nervous system erius it misses as not pass through the blood-brain barrier, so it does not cause drowsiness, typical first steps antihistamines.

Who and how to take

Aerius is prescribed for allergic diseases such as allergic rhinitis (seasonal and perennial), allergic conjunctivitis, acute and chronic urticaria, angioneurotic edema, contact allergic dermatitis, allergic to insect bites, etc. On prescription Aerius can also be used in other allergic diseases.

Aerius is a non-prescription drug, so it can be kept in a home medicine cabinet. But in chronic allergic diseases (eg bronchial asthma) antihistamines should appoint a doctor, as they need to be combined with other drugs that are part of complex treatment.

Assign Erius tablets for adults and children 12 years after one 5 mg tablet per day (usually in one and the same time). Take the drug regardless of the meal, do not chew (they are covered with a special membrane, which allows them to be dissolved only in the intestine, bypassing the stomach), and washed down with a little water.

Who should not take

In tablets Erius little contraindications. They can not be taken during pregnancy, as adequate clinical trials on the effects of the drug in pregnant women has not been conducted. During feeding baby Breastfeeding - a personal choice   breast pills Erius also contraindicated due to the fact that this drug is excreted in human milk. Do not use Aerius tablets to children under 12 years of age for children is available a special formulation of the drug - syrup. Of course, you can not take Aerius and in case of hypersensitivity to its components of the patient - it will have unintended consequences in the form of non-allergic and allergic reactions.

In severe kidney disease in violation of their functions Erius tablets should be taken with caution.

Side effect

Aerius is generally well tolerated, side effects are rare, but it can not be excluded. When the pill Erius may experience fatigue, weakness, fatigue, headache, dizziness Dizziness - if the ground is slipping from under his feet , Dry mouth, increased heart rate, abnormal liver function (rapidly disappear after discontinuation of the drug), nausea, vomiting, diarrhea, flatulence, pain and discomfort in the stomach, and allergic reactions.

Tablets Erius help cope with allergies.

Galina Romanenko