Potassium and magnesium are part of asparkama needed heart muscle (myocardium) for normal metabolism. Homergy Improves metabolism and losing weight without dieting   It provides good myocardial contractility. Therefore asparkam is a part of complex treatment of many heart diseases.

As asparkam effect on metabolism in the heart muscle

The composition includes potassium aspartate asparkama and magnesium aspartate. Potassium is located intracellularly, while his antagonist sodium - extracellularly. Competing with each other, they create the so-called sodium-potassium pump, allowing to maintain normal osmotic pressure in the tissue.

But potassium-sodium pump works only when a power and energy delivered to the magnesium ions that participate in carbohydrate metabolism. Aspartate helps potassium and magnesium ions get into the cell. Thus, all components asparkama involved in metabolism Metabolism: The basis of life of all living things . Especially important and significant this is for the action of the heart muscle or myocardium. Improving metabolism in the myocardium has a beneficial effect in many heart diseases.

Asparkam and chronic heart failure

Chronic heart failure develops in reducing myocardial contractility. If the myocardium can not be reduced to the normal force, it compensates for the lack of frequent power cuts and still can not time to pump all the blood flowing into the heart. This creates a stagnation of blood in the venous system and causes peripheral edema and disruption of the internal organs (for cardiovascular disease in a large circle of blood circulation) or the appearance of fluid in the lungs (pulmonary edema, with cardiovascular disease in a small circle of blood circulation).

For the treatment of cardiovascular disease prescribe medications called cardiac glycosides. They make the myocardium to contract less often and with greater force, that is, have a pronounced positive effect on the heart. Unfortunately, it is quite toxic drugs and their smallest overdose can have severe consequences. Especially dangerous are caused by cardiac glycosides cardiac arrhythmia.

In order to reduce the risk of side effects and overdose of cardiac glycosides, patients designate asparkam. Amid asparkama that improves the metabolism in the myocardium (i.e., makes this a stronger muscle) may also decrease the dose of cardiac glycosides.

Asparkam and coronary heart disease

Coronary heart disease (CHD) develops on the background of atherosclerosis Atherosclerosis - a chronic disease of the arteries When plaques clog blood vessels, including arteries which carry blood to the myocardium, - the coronary artery. As a result of decreased clearance through the coronary arteries to the myocardium with an inadequate amount of blood that carries oxygen and nutrients needed for proper metabolism in its cells.

The main symptoms of IBS are short-term bouts of severe heart pain (angina) associated with sudden spasms of the coronary arteries and interruptions in the delivery of oxygen to the myocardium. These attacks occur first on the background of physical exertion or stress (angina), and then themselves (angina at rest). If time does not remove the spasm of coronary arteries using coronary dilatators funds (usually nitroglycerin tablet under the tongue) may occur necrosis of the heart muscle - Myocardial infarction Myocardial infarction - the most formidable diagnosis .

Ischemic heart disease requires a long complex treatment, which usually includes asparkam. Under the influence of this drug improves metabolism in the heart muscle, which leads to better tolerance myocardium lack of oxygen and nutrients.

Asparkam in disorders of heart rhythm

Cardiac arrhythmias or arrhythmias may occur in violation of the nervous regulation of cardiac activity of the autonomic nervous system (which supplies the internal organs), inflammatory or metabolic diseases infarction, chronic poisoning by some poisons and so on. At this heart rhythm disorders it is almost always associated with impaired ratio of potassium ions, sodium, magnesium and calcium within the cells of the myocardium and in the intercellular space. As a result of a change in excitability of the autonomic ganglia, which set the rhythm of the heart.

Asparkam aligns ratio between potassium and sodium content in the control cells of magnesium and calcium. This leads to the normalization of the electrophysiological processes in myocardium, including the right to restore the depolarization electric potential of myocardial cells.

Asparkam restores myocardial metabolism, which contributes to an overall improvement in its functions.

Galina Romanenko

Validol is the drug of choice for cardioneurosis - pain in the heart, occurring against the backdrop of nervous disorders. Often it is taken with nitroglycerin during strokes, and also as a sedative with nervousness. It will validol and seasickness. However, an overdose of this drug is undesirable.

What is the danger of overdose validol

Validol - a reflex action of the drug. When taken under the tongue, he is active in the cold receptors located in the oral mucosa. This causes a reflex release into the blood of some biologically active substances - histamine, kinins, endorphins and enkephalins.

Endorphins and enkephalins is difficult to overdose - a morphine substances (endogenous opiates), which have a slight analgesic, vasodilatory effects and improves mood. Allocated endogenous opiates in small quantities and when taking an overdose of validol can not be.

But validol overdose may be followed by the release into the blood of a large number of histamine. Histamine - a biologically active substance which is produced in allergic reactions. It can provoke an allergic reaction not only to Validolum, but also to any other substances, including the drug.

Validol Overdose can lead to elevated blood content of kinins. Together with histamine, endorphins and enkephalins kinins dilate blood vessels. At low or labile (changeable) arterial pressure this can lead to a sharp decrease.

Furthermore, kinins cause irritation and light stimulation of the exocrine glands - lacrimal, salivary, gastric mucosa. This gives rise to lacrimation, hypersalivation, nausea and sometimes vomiting.

On the central nervous system (CNS) validol has an inhibiting effect and an overdose can cause CNS depression, including the vital centers - the respiratory and cardiovascular activity. After absorption into the blood validol enters the various tissues, and then metabolized by the liver and excreted in the urine as glucuronides.

Symptoms of overdose

Validol overdose is extremely rare, as it is non-toxic drug. However, do not exceed the recommended daily dose. Validol usually prescribed for one - two tablets two or three times a day, the maximum daily dose - 6 tablets of 50 mg. When you receive more validol possible overdose.

Overdose validol often manifested as nausea, vomiting, watery eyes, and hypersalivation Increased salivation - deviation from the norm   - Effects caused by kinins. In addition, the characteristic signs of low blood pressure - headache and dizziness Dizziness - if the ground is slipping from under his feet Sometimes, especially with a sharp transition from horizontal to vertical, possible loss of consciousness.

In overdose possible validol oppression CNS, including those located in the medulla oblongata respiratory and circulatory centers. In adults, these disorders is not seen, but the children, especially small validol Validol - old, but reliable   it is not necessary to give - menthol can cause them to respiratory disorders.

Overdosing validola can be accompanied by allergic reactions (result of histamine released into the blood), as Validolum itself or any other material. Allergies often in the form of urticaria and angioedema - growing and merging maculopapular rash, swelling passing into the subcutaneous tissue, a spectacular area of ​​the larynx and accompanied by respiratory disorders.

What if I overdose

No specific antidote. If you suspect an overdose validol patient should wash the stomach and take any antihistamine - suprastin, tavegil, Claritin Claritin - histamine receptor blocker   and so on. If after that the patient's condition does not improve, you need to call an ambulance: the patient may require inpatient care.

As validol interacts with other drugs

With most drugs validol blends. But at the same time it is undesirable to use with medications, have a depressing effect on the central nervous system.

Very good validol combined with nitroglycerin - vasodilator effects of the latter is enhanced and prolonged. Can also enhances the effect of drugs, lowers blood pressure.

Validol - this drug has no toxic effects on the body, so it is an overdose is extremely rare. Yet taking it in large quantities is not recommended.

Galina Romanenko