Mirena Intrauterine therapy system has been successfully used in the treatment of certain types of endometriosis, since steadily releases small doses of hormones, thereby inhibiting, growth of the mucous membrane of the uterus (the endometrium). Today, such treatment is often used in endometriosis of the uterus.

How does endometriosis Mirena

Mirena is a hormone-white elastomeric core, placed in a special box covered with an opaque membrane, regulating the release of active principle intrauterine therapeutic system - levonorgestrel. The housing has at one end a loop, which are attached to the filament to remove Mirena. Releases MIRENA known German pharmaceutical company Bayer.

After the introduction of Mirena in the uterus begins to slow at a constant speed of releasing levonorgestrel - a synthetic analogue of the female sex hormone progesterone Progesterone - norm and pathology . A feature spiral action is that it has a mainly local actions which require lower doses of hormones than when taken orally

The constant presence of Mirena in the uterus leads to the fact that in endometriosis regulated menstrual cycle, the duration and decreases the amount of menstrual and intermenstrual bleeding, decreased pain. In some cases mild forms of endometriosis uterus observed regression of lesions up to a full recovery.

Thus immediately after installation Mirena may increase bleeding and spotting, but then (usually within one to three cycles) reduces blood loss by regulating the menstrual cycle, and less prolonged and heavy menstruation. Sometimes menstruation ceases altogether, which is a positive factor for endometriosis, as it is cyclical changes in the uterus contribute to the spread of the disease and its recurrence after treatment.

Mirena also causes an inflammation limited to the uterus, resulting in the uterine cavity is formed by an acidic environment with an increased number of leukocytes, which hampers the promotion of sperm. This may create a risk of infectious-inflammatory process in the uterus.

Do Mirena side effects and how dangerous they are for endometriosis

Mirena - a low-dose hormonal system, so it has side effects dramatically. But sometimes still appear nausea, headache, depression Depression - a little more than a bad mood   or irritability Irritability - you try to control my temper , Painful swelling of the breasts, small irregular menstruation, acne Acne: facial trouble , Hair loss, increased body hair, urticaria, back pain. These side effects do not require the removal of the spiral and tested independently for several menstrual cycles. In endometriosis, they are not dangerous, in fact, cessation of menstruation carries therapeutic function in this disease.

In some cases, self-helix is ​​removed from the uterus, even more rarely perforation (perforation) of the uterus, the development of ectopic pregnancy - such complications could theoretically arise with the introduction of any intrauterine devices, including from the Mirena.

Sometimes the background Mirena in the uterus developing inflammatory processes, this rarely happens, but requires the removal of the spiral.

When MIRENA install contraindicated

Contraindications to set the Mirena are:

• individual intolerance of components;
• pregnancy and lactation;
• Any inflammatory and infectious gynecological, urology, proctology processes, including postpartum endometritis, infected abortion;
• oncological diseases;
• cervical dysplasia;
• vaginal bleeding of unknown origin;
• lowered immunity and susceptibility to common infectious and inflammatory diseases;
• any structure uterine disorders both innate and acquired nature, including adhesion in the uterus;
• severe liver disease in violation of its functions.

In any case, the decision and the introduction of Mirena endometriosis takes the doctor after a thorough examination of women. In severe cases of endometriosis MIRENA is usually not used. But it can be used for suppression of recurrence of the disease after the active hormonal therapy or following surgery.

Mirena is a hormonal contraceptive quality, which is now often used to treat certain types of endometriosis.

Galina Romanenko

Prevent unwanted pregnancy by using hormonal contraceptive tablets for many modern women was vital. Therefore, these drugs produced in abundance. Choose among them "their" drug of the woman can not afford, it should be done only after a preliminary examination of the doctor.

What is the basis effect of hormonal contraceptives

The action of hormonal contraceptives based on the fact that by inhibiting the secretion of certain hormones, delayed and inhibited oocyte maturation in the ovaries of women. Hormonal contraceptives lasts 21 days, then their reception is interrupted and it causes rejection of the mucous membrane of the uterus and bleeding menstrualnopodobnoe.

All hormonal contraceptives are divided into simple (containing one hormone, today they are not very reliable and almost never used) and combined (contain some hormones). In addition, hormonal contraceptives may be monophasic (all taken within 21 days of a tablet containing the same amount of hormone), and two-, three-phase (amount of hormone in the tablets varies according to the day of the menstrual cycle The days of the menstrual cycle: Four phases   - Such tablets are usually manufactured in different colors).

Silest and its mechanism of action

Silest - a monophasic combined hormonal contraceptive, which is composed of two synthetic hormones: norgestimate (analogue progesterone Progesterone - norm and pathology   hormone second half of the menstrual cycle that starts after ovulation) and ethinyl estradiol (an estrogen analogue - hormones first half of the menstrual cycle).

Under the influence of these hormones inhibit the production of gonadotropin-releasing hormone of the pituitary gland (the main endocrine gland located in the brain, which affects all the other endocrine glands, including the sex glands) - follicle-stimulating and luteinizing hormone that normally stimulates the maturation of the egg and cook endometrium to receive the embryo. As a result, the egg does not mature and are not released from the ovary for fertilization (ovulation does not occur), so pregnancy is not possible. Influenced Silest occurs as the allocation of viscous mucus in the canal of the cervix, which prevents sperm into the uterus.

When receiving Silest inside he quickly absorbed into the blood, partially decomposed in the liver and then excreted in urine and feces.

Indications and Contraindications

Indications for admission Silest - prevention of unintended pregnancies. Contraindications Silest are:

• inflammatory diseases of the veins and their blockage (thrombophlebitis);
• violation of blood coagulation (increased tendency to thrombosis);
• cerebral atherosclerosis (blockage of the arteries of atherosclerotic plaques - the threat of a stroke);
• violation of patency of the arteries that supply blood to the heart muscle (myocardial infarction threat);
• some types of hereditary anemia;
• any malignant tumors (particularly hormone-dependent, such as breast cancer Breast cancer: what every woman needs to know   or uterus);
• Vaginal bleeding of unknown origin;
• benign tumors of the liver;
• any disease of the liver, which are accompanied by violation of its functions;
• genital herpes;
• pregnancy (possible fetal malformations and miscarriages);
• breast-feeding a child;
• smoking after 30 years (many times increases the risk of side effects).

With caution and only under medical supervision Silest can take women suffering from cardiovascular diseases (including hypertension), diabetes, asthma, gallbladder disease, varicose veins, uterine fibroids, depression Depression - a little more than a bad mood   (persistent low mood), epilepsy.

Side effects that may occur when receiving

When receiving Silest may experience the following side effects:

• from the gastrointestinal tract: nausea, vomiting, abnormal liver function (including the appearance of jaundice staining of the skin), irritation of the gallbladder;
• Central nervous system: headache (including in the form of migraine), depressed mood;
• on the part of the cardiovascular system: high blood pressure;
• on the part of the endocrine system: spotting and bleeding, the complete absence of menstruation, a sense of tension, and breast tenderness, discharge from the nipples, body weight change (increase or decrease), the change in sex drive;
• on the side of the genital organs: thrush, cervical erosion, increased secretion of cervical mucus;
• by the organs of vision: dryness and irritation when wearing contact lenses;
• of the skin and its appendages: the appearance of age spots on the face (chloasma), hair loss;
• an allergic reaction (rare).

How to take Silest

Silest take on the first day of menstrual bleeding, one tablet a day at the same time for 21 days, then make a seven-day break (at this time begins menstrualnopodobnoe bleeding), a week (even if the bleeding has not ended) are beginning to take the next pack of pills . Efficacy is reduced by the delay in taking the pill more than 12 hours - in this case, you should use additional methods of contraception.

Silest - qualitative hormonal contraceptive marketed pharmaceutical concern CILAG AG INTERNATIONAL (Switzerland).

Galina Romanenko