Jodomarin - a drug, which comprises an inorganic iodine. Since iodine is needed by the body, above all, for the normal functioning of the thyroid gland, jodomarin take to prevent and treat diseases of the body. In addition, jodomarin prescribed to pregnant women, nursing mothers and young people who need increased amounts of iodine.

The mechanism of action jodomarin

Active ingredient jodomarin is potassium iodide - a substance containing an inorganic iodine. Jodomarin produces a German pharmaceutical company Berlin-Chemie in tablets of 100 and 200 micrograms (jodomarin jodomarin 100 and 200). Other pharmaceutical companies, potassium iodide is released under the title: antistrumin, yodandin, yodbalans iodide, potassium iodide, yodostin, mikroyodid.

Jodomarin mechanism of action is related to the fact that iodine is essential for normal thyroid function. Thyroid hormones (thyroid hormones) are important regulators of metabolism, they actively influence the function of the rest of the internal organs and systems.

Especially important is the normal function of the thyroid gland to work the cardiovascular and nervous system. In addition, it is reflected in the work of the endocrine glands, supporting reproductive (fertility) function of the woman and the child's growth. It reflects the state of the thyroid and mammary glands of women: in violation of its functions are often formed of mastitis.

In the body, potassium iodide misses the thyroid, where enzymatically decomposed to form elemental iodine. This iodine is for the construction of the thyroid hormones, the main ones are thyroxine Thyroxine - the main thyroid hormone   (abbreviated - T4) and triiodothyronine (T3). These hormones are complexed with a protein that is deposited in thyroid tissue and stored therein for a few days or weeks.

When insufficient iodine in the diet thyroid function is broken, which manifests itself in a variety of diseases, but mainly in the form of endemic goitre -kompensatornogo (more fabric, the more hormones) proliferation of thyroid tissue under the influence of pituitary thyrotropic hormone (TSH). Jodomarin able to suppress the growth of endemic goiter, since the increase of iodine in the thyroid gland leads to increased production of thyroid hormones Thyroid hormones: mechanism of action and physiological effects   and to suppress the secretion of pituitary TSH. Furthermore, jodomarin normalized ratios of T3 to T4.

The daily requirement of iodine adult - 150-200 mg, in our country, the people with food consume about 50 micrograms of iodine, so in many parts of the courses are conducted preventive iodine preparations, especially for children, adolescents and pregnant women.

Indications and contraindications

Jodomarin appointed for both treatment and prevention:

• deficiency of iodine in the diet in the locality for the prevention of endemic goiter, especially in childhood and adolescence, during pregnancy and while breastfeeding;
• for the prevention of recurrence of goiter after the suppression of its growth with the help of conservative or surgical treatment;
• for the treatment of diffuse euthyroid (normal thyroid function) goiter caused by iodine deficiency in children, adolescents and adults under the age of forty years;
• in preparation for the removal of the thyroid gland over its increased function (hyperthyroidism) - this leads to a temporary decrease in thyroid function;
• radioactive substances in contaminated areas to prevent the absorption of radioactive iodine by the thyroid gland and radiation protection.

Admission jodomarin Jodomarin - will fill the deficit of iodine in the body   is contraindicated in:

• at elevated thyroid function (hyperthyroidism);
• in toxic adenoma (benign tumor) thyroid nodular goiter, if applied at doses of 300 micrograms (except in cases of preoperative preparation - using jodomarin suppress thyroid function);
• dermatitis herpetiformis senile when Duhring - chronic recurrent itching dermatosis, in which patients appear intolerant of potassium iodide;
• when individulnoy hypersensitive to the components of the drug.

Side effects

Jodomarin in prophylactic doses generally well tolerated. However, when applied in therapeutic doses may be side effects. The main side effects are manifested by the endocrine system. Thus, upon receipt of potassium iodide at a dose of 150 ug hidden Ray Hyperthyroidism: increased secretion of thyroid hormone   It may appear next to the characteristic symptoms, and when taking it in the dose, 300 micrograms may show signs of hyperthyroidism. With extreme caution should be used jodomarin elderly patients with different types of goiter.

Allergic reactions are also possible.

Galina Romanenko

Hyperthyroidism can develop at different diseases of the thyroid gland, which require different treatment strategies. But high blood levels of thyroid hormones requires immediate treatment regardless of the underlying diagnosis. Therefore, the patient is prescribed drugs that inhibit thyroid function and at the same time continue to examine him to establish a definitive diagnosis.

How to suppress thyroid function

Suppress thyroid function in hyperthyroidism is necessary in the first place, as the long-term effect on the body increased blood concentrations of thyroid hormones may adversely affect the activity of the whole organism. Especially hard hyperthyroidism affects the state of the heart and blood vessels. In addition, all of a sudden such a patient can begin thyrotoxic crisis - a serious condition that can lead to death.

Thyroid function can be suppressed with the help of medical treatment, the appointment of radioactive iodine or by removing most of the thyroid gland using surgery.

Conservative treatment of hyperthyroidism, thyroid

Conservative treatment of hyperthyroidism, thyroid Hypothyroidism thyroid cancer - treatment is carried out for life   carried out with the help of drugs that suppress the synthesis of thyroid hormones (pathogenetic treatment). In addition, untreated, hyperthyroidism improves impaired operation of various bodies (symptomatic treatment).

Medications that suppress thyroid function, called antiterioidnymi. In our country, used mainly antithyroid drugs belonging to the group tionamidov - Mercazolilum, tiamazol, propylthiouracil. These drugs inhibit the enzyme action of thyroid peroxidase, which participates in the synthesis of thyroid hormones Thyroid hormones: mechanism of action and physiological effects , Thereby inhibiting their formation and entry into the blood.

Conservative treatment is applied with a slight increase of the thyroid gland Increase in thyroid - that underlies the disease . If thyroid hyperthyroidism is bulky and compresses the surrounding tissue, most often it is removed by surgery.

It starts with the appointment of conservative treatment of large (drums) doses of antithyroid drugs, such as 20-40 mg per day merkazolila. After a few weeks (guided by the patient's condition, usually between three and eight weeks) examined the blood levels of thyroid hormones (T4 - thyroidin and T3 - triiodothyronine), and thyroid stimulating pituitary hormone (TSH). Reduced levels of T4 and T3 in combination with an increase in TSH levels into the normal range indicates a bong, that you can go on a maintenance dose of the drug - 2, 5-10 mg per day. This dose the patient receives merkazolila usually within a year.

Against the background of such treatment in a third of patients develop persistent remission. Sometimes used to treat hyperthyroidism combination of anti-thyroid drugs and synthetic analogs of thyroid hormones (most often it is a L-thyroxine). Recent suppress blood levels of TSH, which, after the abolition of anti-thyroid hormones can stimulate the secretion of thyroid hormones, causing exacerbation of hyperthyroidism.

The main side effect is the development of agranulocytosis merkazolila - reducing the number of leukocytes in the absence of granular white blood cells. This contributes to a sharp decline in immunity and the accession of many infections. Occasionally there are allergic reactions.

Treatment of hyperthyroidism with radioactive iodine

This is a very effective method of treatment, which in most cases contribute to the emergence of long-term stable remission. The disadvantage is that the radioactive iodine is not available in all hospitals.

The mechanism of action of the radioactive iodine based on the fact that, as with any other inorganic iodine, it immediately enters the thyroid, it falls inside the cells (thyrocytes) and destroys them. Radioactive iodine is produced in the form of the sodium salt of iodine 131 in the solution and capsules for oral administration.

Surgical treatment

In hyperthyroidism often performed incomplete (subtotal) removal of the thyroid gland. The operation is prescribed in the case, if the size of the prostate is very large and it compresses the surrounding organs and tissues, as well as recurrence of hyperthyroidism after the conducted conservative treatment and an allergy to antithyroid drugs.

When subtotal resection removed the bulk of cancer, leaving only a few milliliters of tissue. At the same time before the surgery required to carry out medical treatment, the vast thyroid function.

With proper adequate treatment of patients with hyperthyroidism Hyperthyroidism: increased secretion of thyroid hormone   can continuously be in a state of remission.

Galina Romanenko