- Endometriosis uterus - one of the most frequent diseases in women
- Treatment
Endometriosis is diagnosed in the uterus of a large number of patients who go to the doctor in connection with gynecological problems. According to some endometriosis can be observed in up to 50% (from 10% to 50%) of women of reproductive age. The disease is often a diagnostic laparoscopy finding in the survey women for infertility.
Some women suffer from endometriosis for many years, even without knowing it because the disease may be asymptomatic. But it can bring a lot of trouble, especially in the form of heavy and painful menstrual blood loss as a result of developing iron-deficiency anemia.
Why endometriosis uterus begins
Endometriosis is called the development of tissue-like mucous membrane of the uterus (the endometrium) in other organs. In endometriosis uterine such tissue develops in the thickness of the muscular layer of its wall. Endometriosis uterine relates to the internal forms of the disease.
The causes of this disease are currently not fully understood, but it is believed that the main causes are neuroendocrine disorders and immune disorders. In most cases, uterine endometriosis associated with increased secretion of female hormone estrogen, which contribute significantly to the widening of the mucous membrane of the uterus during the first half of the menstrual cycle.
The risk of endometriosis is enhanced during the various manipulations and operations in the uterus, for example, in childbirth, especially if they are accompanied by a manual removal of the placenta, abortions, spontaneous abortions, diagnostic and therapeutic manipulation in the uterus. All this leads to injury of the uterus wall, which may further crosses with blood cells of the endometrium. There they grow and begin to respond to cyclical hormonal changes in a woman's body in the same way as the normal endometrium in the uterus.
But the cells of the endometrium during menstruation, many women fall into the interior of the uterus, endometriosis is developing not all. This happens due to the fact that in the normal cells of the immune system destroys these "stray" endometrial cells, not allowing them to take root where it is not necessary. When violations of the immune system, this protection factor is weakened or absent, which leads to the development of the disease.
It is thought that counts, and a genetic predisposition to the disease.
In the uterus the disease process may be diffuse (spread evenly) and focal (nodal) form.
What characterizes the uterus endometriosis
By nature Endometriosis is a benign process, the growth of which is shown a tissue having morphological similarity to the endometrium. This tissue is cyclical changes typical of the menstrual cycle, but the tissue is outside the uterus. Scientists who study the nature of the disease, came to the conclusion that there are several theories. The greatest importance is attached to migrated inflammation, disruption of the body's immunological status and hormonal regulation. We must also consider the fact of hereditary predisposition.
As evidence of the role of hormonal imbalance indicates that the earliest cases of endometriosis were found in girls aged 10-11 years. This is the age of formation of hormonal regulation, when the first menstruation. Hormonal dysfunction can be expressed in the development of the syndrome or SNF neovuliruyuschego follicle in a short menstrual cycle, long and heavy menstruation. In a study of patients revealed changes in the level of secretion of sex hormones and central concentration of receptors for sex hormones estrogen
Estrogen - the key to bone health
and progesterone
Progesterone - norm and pathology
. A study of the hormonal profile of women reveals the features of the dynamics of hormone levels, which in the future will greatly assist in the selection of treatment tactics.
Pathological process can have genital and extragenital localization. Endometriosis refers to the uterus and genital localization is called adenomyosis.
There are two clinical forms of the disease:
The prevalence of pathological process with internal endometriosis determines the stage of the disease. The most favorable course have initial form. In the case of the first and second stages of the disease process is distributed more muscle and mucosal membranes. The defeat of the body of the uterus until the serous cover is characteristic of the third stage. Endometriosis uterus can occur in isolation in a process involving only the body of the uterus, but may change in adjacent organs and pelvic peritoneum. The fourth stage of the disease is characterized by a complicated one for the flow that causes the development of clinical symptoms.
In rare cases, adenomyosis are asymptomatic. The localization of the pathological process, its prevalence and form lesions determine the main clinical symptoms. The main complaint is pain. Pain can wear intense, with some patients noted the presence of persistent pain in the lower divisions. If adenomyosis lesion of the peritoneum occurs, nearby organs, the pain radiates to the lumbar region, coccyx or anus. There is no scientific proof of the existence of a clear interconnection pain intensity and severity of the disease. In the initial stage of the disease pain can be pronounced with minimal changes.
Besides pain noted the appearance of menstrual disorders in the form of irregular menstruation, prolonged discharge from the genital tract, which appear at different periods of the menstrual cycle and have a dark brown color, therefore such allocation is called "daubs". Adenomyosis may be the cause of disease, discomfort during sexual intercourse. The most negative impact of this disease on the health of the woman and her reproductive function associated with the development of infertility.
It is impossible to ascertain the diagnosis of disease based only on clinical evaluation. The main importance is attached to instrumental methods of diagnosis, allowing to describe in detail the defeat of the uterus.
In the case of internal endometriosis can be traced to the dependence of clinical symptoms of certain phases of the menstrual cycle. An objective examination of the patient on the gynecological chair size of the uterus will be increased in the second phase, that is, in the days before the expected menstruation. The uterus is enlarged to fill the 6-8 week of pregnancy. This feature also applies to the severity of pain. Shortly before and during the first few days of menstruation pain increases dramatically. In this connection, it is recommended to carry out a dynamic examination on different days of the cycle, so that you can see the difference between symptoms and diagnose adenomyosis
Adenomyosis - diagnosis endometrioid lesions of the uterus
and other diseases of the reproductive sphere.
Symptoms
The main symptoms of any kind of genital (sex organs) Endometriosis is a painful menstruation (dysmenorrhea). When the disease of the uterus there are abundant painful menstruation (menorrhagia). Moreover, this disease is characterized by and metrorrhagia - irregular intermenstrual bleeding.
Bleeding these have a long character and tend hardly treatable. They can not stop even scraping
Scraping - heavy and unsafe procedure
mucous membrane of the uterus.
But in some cases the disease is asymptomatic and detected incidentally during routine inspections.
Diagnostics
The diagnosis of this disease gynecologist may suspect on the basis of complaints by women. Survey of the gynecologist, if the changes are in the body of the uterus, usually nothing. But nodular form, if the nodes are large enough, they can be felt. During vaginal examination
Ultrasonography (US) of the uterus is the main additional method of identifying this disease is carried out using a vaginal ultrasound probe. To clarify the diagnosis, and apply other methods: X-ray, CT and magnetic resonance imaging, hysteroscopy (endoscopic examination of the uterus using a hysteroscope).
Work is also a blood test for the presence of certain tumor markers characteristic of endometioza (CA-125, CA 19-9) - so you can not only refine diagnosis of the disease, but also to assess the severity of its manifestations, as well as to monitor the effectiveness of therapy. Be sure to explore the female hormones.
Treatment
Treatment begins with conservative methods. Since most women have an increase in estrogen secretion, the activity of these hormones is suppressed by means of individualized hormone replacement therapy (anti-estrogens, progesterone or synthetic analogs agonists Riesling-hypothalamic hormones that suppress the secretion of pituitary gonadotropins).
With the ineffectiveness of conservative treatment is carried out the operation, during which pathological lesions in the muscle layer of the uterus cauterizing different ways. In some cases, surgery is performed supravaginal removal of the body of the uterus (the cervix with preservation). After the operation is also assigned long-term (several months) hormone therapy.