Duphaston is often used for the treatment of mild forms of endometriosis. This drug inhibits the action of estrogen. Since estrogen is the main cause of the disease is not progressing. Djufaston operates smoothly, rarely has side effects and has a few contraindications for use.
How does endometriosis djufaston
Duphaston (active substance - dydrogesterone) is a progestogen - a synthetic analogue of natural progesterone. He acts mainly on the uterus mucosa (endometrium), inhibiting its growth (proliferation) and causing the mucosa secrete secret needed to introduce it into the wall of the embryo.
The main problem with endometriosis - is overgrowth of the endometrium. Since progesterone
Progesterone - norm and pathology
while underfunded, the endometrium initially very long and growing strongly, and when the amount of estrogen decreases, begins to separate from the uterine wall sections, accompanied by prolonged bleeding.
Djufaston positive effect in endometriosis. It inhibits proliferation, but not at the same time suppresses ovulation (release of an egg from the ovary), so it can be used a woman who wants to get pregnant. In addition, djufaston reduces the pain of endometriosis, because of pain accompanied by increased production and release of biologically active substances prostaglandins. This causes insufficient blood supply to the muscle layer of the uterus, which leads to its spastic contractions, accompanied by severe pain. Djufaston reduces or even completely eliminates this kind of pain. Also reduced menstrual and intermenstrual bleeding. Djufaston also inhibits neoplastic transformation - regeneration areas of endometriosis into cancer cells.
Pregnancy is not a contraindication for receiving duphaston, moreover, in the first trimester of pregnancy djufaston often prescribed to prevent miscarriage, as all progesterone inhibit muscle contractions. Djufaston Available in tablets of 10 mg, which is taken orally.
As prescribed
Treatment of endometriosis djufaston usually conducted in the early stages of the disease, when there was still significant pockets of endometrial growths. Influenced duphaston suppresses endometrial proliferation not only in the uterus, but also in other organs and tissues.
The manufacturers of this drug developed general rules of the destination duphaston endometriosis. But today, it is believed that endometriosis treatment approach every woman should be individualized, so the dose and duration of application should be chosen by your doctor. The doctor usually appoints duphaston daily dose, which is distributed on several doses throughout the day.
In endometriosis this drug pronimayut from 5th to 25th day of the menstrual cycle
The days of the menstrual cycle: Four phases
or continuously for at least six months and sometimes longer - the duration of the course is determined by a physician and often lasts up to nine months. This leads initially to stop proliferation of small areas of endometriosis, and then to their regression (atrophy).
Today djufaston prescribed mainly for small forms of endometriosis or after organ operations when removed endometriosis. In this case, djufaston prevents the occurrence of relapses. When common forms of endometriosis used other hormonal drugs that act more harshly suppress ovulation
Ovulation - How to determine as accurately as possible?
and often have side effects.
Side effects and contraindications
Djufaston rarely produce side effects, however, they occur:
- Central nervous system - headaches, including migraine form;
- on the part of the reproductive system - very rarely develop breakthrough uterine bleeding (which can suppress the increase of the dose), may also appear pain in the breast;
- of the liver - transient disturbances of its function with some pain and jaundice;
- from the blood - hemolytic (destruction of red blood cells accompanied by processes) anemia;
- Other side effects - swelling in the legs (very rare), allergic reactions.
Admission duphaston contraindicated in case of hypersensitivity to its components of the female organism, Dubin-Johnson syndrome and Rotor (congenital liver diseases with impaired metabolism of bilirubin). In addition, since djufaston excreted in breast milk, it is not recommended for use during baby feeding
Breastfeeding - a personal choice
feeding.
Duphaston has a positive effect in endometriosis.
Galina Romanenko
Article Tags:
- djufaston,
- treatment of endometriosis