Ointment (more correctly, cream) Makmiror complex is a safe and effective tool not only for the treatment of infections of the external genitalia of women, but also for the prevention of candidiasis, which may develop during the treatment of these diseases.

How does

Cream Makmiror complex - a composite tool for the local treatment of vaginitis (inflammation of the vagina and external genitalia of women) of different origin.

Makmiror produced pharmaceutical company Polihim (Italy), in which the research labs have developed a new synthetic drug which is a derivative of nitrofuran - nifuratel. Nifuratel is an excellent antiseptic, active against a number of bacteria, chlamydia Chlamydia: insidious and widespread disease , Trichomonas and fungi - the main pathogens causing vulvovaginitis. A feature of nitrofuran derivatives has always been that it is very slow to develop resistance of microorganisms. But the preparations of this series of past generations have significant side effects. Nifuratel has all the advantages of nitrofurans and with almost no side effects.

The structure of the complex also includes Makmiror Nystatin Nystatin - help with candidiasis   - Antifungal antibiotic. Overall cream Makmiror complex (1 g of cream contains 100 mg nifuratel and 40,000 units nystatin) has both curative and preventive action - prevents the development of candidiasis, which often develop during treatment vulvovaginozov especially Trichomonas origin.

However, despite the ease of use, this cream can be effective only if the laboratory control sensitivity to infectious agents, and cure disease. This means that the self-administration of such drugs should be avoided.

In what diseases is effective cream Makmiror

Vulvovaginitis - an inflammation of the external genitalia and the vagina of women. This disease can be caused by different infectious agents. This can be a bacterial infection that gets both from without and from the bloodstream (staphylococci, E. coli and others). Most bacterial pathogens vulvovaginitis showing sensitivity to nifuratel, which is part of the cream Makmiror complex. No less sensitive to it chlamydia, trichomonas Trichomonas - leads to infertility   and mushrooms - they are often the cause of inflammatory processes of female genital mutilation.

Vulvovaginitis often caused by several infectious agents. Vital functions of most of them is suppressed cream Makmiror complex. In the treatment of bacterial infections and trichomonas often develop yeast infections Fungal infection: to prevent and defeat But their development is immediately suppressed by members of cream Makmiror components.

How to apply

Cream Makmiror produced with a special dosing applicator which is provided with scale marks of the content in cream applicator in grams.

The applicator is screwed to the tube of cream, squeeze the right amount in grams, then unscrewed from the applicator tube is introduced as deeply as possible into the vagina and fully squeezed. For girls and young women has a special applicator nozzle that allows you to not injure the hymen.

Normal dosage cream Makmiror complex - 2, 5 g once or twice a day, usually in the morning and (or) the evening for 8 days. During the course of treatment with a cream Makmiror complex should avoid sexual contact. It must be treated and female sexual partner.

Contraindications for use and side effects

Contraindications for the use of cream Makmiror complex is the only idiosyncrasy of the drug. Side effects can be distinguished only allergic reaction to this drug. Not applicable nifuratel negative impact on spermatogenesis, fertilization or pregnancy.

However, it is used with caution in the first trimester (12 weeks) of pregnancy when there is a tab tissues and organs of the fetus - cream Makmiror partially absorbed into the blood and can be introduced into the body of the fetus. Also with caution this cream is used in the treatment of nursing mothers - included in the cream components are excreted in mother's milk.

Usually cream Makmiror complex is very well tolerated and rarely causes any side effects, cases of overdose have been reported.

Cream Makmiror complex - an effective tool for the treatment of vaginitis in women.

Galina Romanenko

Orungal - a modern, effective antifungal agent active against most pathogens of fungal infections. It produces orungal pharmaceutical company Janssen Pharmaceutica (Belgium) in the form of capsules and oral solution.

Orungal - especially actions

Orungal - a modern antifungal drug broad spectrum of action. Active substances it is itrikonazol. It is produced only in dosage forms for oral administration (capsules and solution). Upon receiving orungala it is rapidly absorbed in the intestine and enters the blood is distributed in the body, while its concentration in the skin and nails are several times higher than in blood. In the tissues of the internal organs it is also more concentrated than in the blood. The highest concentration in the tissues orungala achieved two weeks after his regular admission. It decomposes orungal hepatic metabolism of numerous products, some of which also have an antifungal effect. Excreted in the bile and urine.

When injected into tissue, infected with pathogenic fungi, orungal prevents the formation in the cell membranes of fungi of ergosterol, leading to the death of these cells.

Sensitivity orungalu exhibit most pathogenic fungi which cause disease in humans. The only exceptions are a few quite rare, including tropical fungi that cause diseases such as zygomycosis, fizarioz, skopulyariopsioz and alleshiroz.

At any fungal infections will orungal

Orungal used for fungal infections caused by susceptible pathogens to it. This is a fungal disease of the skin (microsporia, trichophytosis, jock itch Jock itch: fungal infection , Athlete's foot, ringworm multicolored Colorful lichen: relapses , Candida skin lesions and so on), mucous membranes (candidiasis or thrush), nails (onychomycosis caused by various pathogens fungal infection), eye (fungal keratitis), as well as systemic fungal infection that affects the internal organs, including the brain.

Contraindications for use

Orungala peculiarity is that it is not combined with the administration of many other drugs are degraded in the liver by the same enzyme belonging to the family of cytochromes, - CYP3A4. The use of such drugs concurrently with orungalom enhance its side effects on the heart - the heart muscle is reduced with a smaller force. These drugs include terfenadine, astemizole, mizolastine, cisapride, dofetilide, quinidine, pimozide, Levo, sertindole, simvastatin and lovastatin, midazolam and oral triazolam. In addition, together with orungalom can not be applied preparations of ergot alkaloids such as dihydroergotamine, ergometrine, ergotamine and metilergometrin. Orungal also contraindicated if you are hypersensitive its components the body of the patient, pregnancy and breast-feeding Breastfeeding - a personal choice   feeding.

Precautions orungal prescribed for disorders of the liver, kidneys and cardiovascular system.

What side effects may give orungal

Orungal gives little side effects. The worst side effect is the suppression force of heart contractions (mainly due to the reduction of potassium in the blood). This leads to the fact that the blood in the large and small circles of blood circulation stops and starts effectively pumped stagnate. Stagnation in the systemic circulation leads to edema, and small - to a violation of the respiratory function and the appearance of shortness of breath. In healthy people, these side effects usually do not happen, but those who suffer from disorders of the cardiovascular system, liver (liver orungal decomposes) or renal (kidney displayed through a significant part of it) side effects can be quite heart. Similar problems may arise while taking orungala simultaneously with several other drugs.

In addition, side effects may occur on the part of the digestive system in the form of nausea, vomiting, diarrhea, abdominal pain, constipation, transient liver dysfunction (in very rare cases develop chronic hepatitis). From the nervous system can cause headaches, dizziness, neuralgia Neuralgia - the scourge of the elderly . In women, the menstrual cycle is possible. There are also various types of allergic reactions from hives to the syndrome of Stevens - Johnson (severe lesions of the mucous membranes of the internal organs).

Orungal - it is an effective antifungal agent. Like many other antifungals, it can produce side effects, and should be used only on prescription.

Galina Romanenko