Side effects Trichopolum

On the part of the digestive system:

• dyspepsia, dry and / or metallic taste in the mouth;
• stomatitis;
• drug pancreatitis (which is reversible for the abolition of the drug);
• changes in the level of liver samples;
• hepatitis (rarely).

From the nervous system and sensory organs:

• neuropathy;
• myopia;
• diplopia;
• headache;
• ataxia;
• dizziness;
• cerebellar syndrome.

From the side of hematopoiesis:

• reducing the number of blood cells: anemia, thrombocytopenia, agranulocytosis.

Other side effects:

• allergic reactions (rash, anaphylaxis, angioedema);
• change in urine color to red-brown.

Contraindications

Contraindications: children's age (up to 6 years), intolerance to metronidazole, or other components of the drug, pregnancy up to 12 weeks, breast-feeding Breast-feeding: feed - and no nails! , Kidney diseases, blood diseases.

Use during pregnancy and breast-feeding

Since metronidazole is rapidly absorbed through the placenta, it is contraindicated in pregnancy for up to 12 weeks. When pregnancy over 12 weeks Trichopolum can be used under strict indications and under strict medical supervision. Metronidazole also passes into breast milk, so if during the period of breastfeeding there is a need to accept Trichopolum, breast-feeding should be discontinued.

Cautions

• Trichopolum kidney disease should be taken strictly under the supervision of a physician;
• use Trichopolum Trichopolum - indications for use are wide enough   in the complex therapy (amoxicillin) is not recommended for persons under eighteen years of age;
• throughout the period of treatment should monitor the status of the peripheral blood;
• during the treatment of trichomoniasis in women and Trichomonas urethritis in men, patients should refrain from sexual intercourse; In addition, for the successful treatment of trichomoniasis require treatment of both partners;
• while taking metronidazole should refrain from consumption of alcoholic beverages, as development disulfiramopodobnyh reactions (sudden epigastric pain, feeling hot, headache);
• Caution should be exercised in the appointment of Trichopolum patients with pathologies of the central nervous system;
• liver failure Trichopolum Trichopolum - he treats?   should be administered under strict indications and under strict medical supervision, because of the possible accumulation of the drug and the deterioration of the patient up to hepatic coma;
• Trichopolum after use may cause candidiasis oral mucosa, genitals, digestive tract, this condition requires the use of antifungal agents;
• during application Trichopolum may be some variation in the biochemical analysis: changes in transaminase levels, glucose Glucose: The energy source Triglycerides.
• Trichopolum during treatment, you should avoid working with complex mechanisms and management of road transport because of the risk of dizziness, confusion, seizures.

Interaction with other drugs

Trichopolum may increase the effects of coumarin derivatives, so when they joint appointment requires correction dose of anticoagulant.

Agents acting on the liver microsomal enzymes, may increase or decrease the action Trichopolum, so inducers of microsomal enzymes (phenobarbital, phenytoin) may reduce the effect of Trichopolum, through faster elimination of the drug; inhibitors (cimetidine) opposite the output time can be lengthened Trichopolum from the body, which leads to an increase in its concentration.

In an application with lithium Trichopolum, you must carefully monitor the concentration of lithium in the blood, since it may increase the toxic effect.

Trichopolum may enhance the toxic effect of astemizole and terfenadine on the conducting system of the heart, extending the range of Q-T, which increases the risk of arrhythmias, including fatal.

Metronidazole increases the side effects of disulfiram (psychosis, disorientation in space), so that their combined use is not possible. Metronidazole should be appointed within two weeks after discontinuation of disulfiram.

Trichopolum may increase the toxicity of fluorouracil.

Overdose Trichopolum

Overdose symptoms may include nausea, vomiting, convulsions, ataxia. Treatment for overdose is directed to the early elimination of the drug (possible hemodialysis), and relief of symptoms.

Storage conditions

Trichopolum should be stored in a dry, well-ventilated place, away from direct sunlight, at room temperature.

Sulfa drugs

Sulfa drugs - a chemotherapeutic antimicrobials. Sulfonamides are active against bacteria, certain protozoa (e.g., malaria and toxoplasmosis pathogens) and chlamydia. Their action is mainly due to a violation of Education microorganisms necessary for their development of folic acid and dihydrofolic. Since sulfonamides are close in structure to para-aminobenzoic acid, the microorganisms necessary for their development, they are captured by the microbial cells, disrupting the metabolic processes in it and thus rendering bacteriostatic (suspend development of microbial cells) action.

The mechanism of action Biseptolum

Biseptolum (INN-to-trimazole) - is a combined antibacterial preparation belonging to the group of sulfonamides. Biseptolum has a broad spectrum of antibacterial action, both of its components involved in blocking the formation of folic acid and dihydrofolic in microbial cells, thereby disrupting the formation of RNA and DNA of microorganisms, protein synthesis, thereby causing the death of microbial cells. Biseptolum active against nearly all groups of bacteria, Chlamydia, fungi and protozoa. Drug resistance, some types of bacteria and viruses.

Biseptolum able to inhibit the vital activity of beneficial intestinal wand, which reduces the formation of B vitamins in the intestines and can cause dysbacteriosis.

If ingestion Biseptol rapidly absorbed into the blood and is well distributed in the body. Its action begins within an hour after receiving the tablets and maintained for ½ days .. In Biseptolum high concentrations accumulate in the lungs and in the urine, a smaller quantity of vaginal secretions, secretions and prostate tissue, middle ear fluid, spinal fluid, bile, bones, saliva, aqueous humor, breast milk.

After 12 hours of Biseptol decomposed in the liver and excreted (approximately 72 hours) is mainly via the kidneys, but a small part, through the intestines.

Indications for use

Currently any infection is treated after analysis sensitivity thereto antimicrobials. This is especially true of chronic infections.

Biseptolum used to treat diseases caused by microorganisms susceptible to the drug:

• Respiratory infections (bronchitis, pneumonia, pleurisy, lung abscess, and others.);
• infections of the nasopharynx and the middle ear (otitis, rhinitis, sinusitis, sore throat, inflammation of the pharynx, larynx)
• childhood infections such as scarlet fever, whooping cough;
• infections of urinary organs (inflammation of the kidneys, urinary tract, bladder, prostate, sexually transmitted diseases, etc.).
• infections of the digestive system (dysentery, cholera, typhoid, paratyphoid, salmonellosis Salmonellosis - features of the disease , Inflammation of the gallbladder and biliary tract, inflammation of the stomach and small intestine, caused by some types of E. coli, etc.);
• infections of skin and soft tissue (pustular rashes, boils, abscesses of the skin and subcutaneous tissue, wound infections);
• of bone infections (acute and chronic osteomyelitis);
• acute brucellosis, septicemia, peritonitis (peritonitis), inflammation of the membranes of the brain (meningitis), brain abscess, malaria.

Contraindications

Admission Biseptolum contraindicated:

• in case of hypersensitivity to the drug or to other sulfonamide;
• Pregnancy and breast-feeding Breast-feeding: feed - and no nails!   Child;
• children up to three months of life;
• in violation of liver or kidney function;
• blood diseases, such as certain types of anemia, disorders of the white blood cells (leukocytes insufficient, including granular leukocytes - neutrophils) and other diseases;
• in cases involving folic acid deficiency.

With care apply Biseptol in bronchial asthma and thyroid disease Thyroid disease - women at risk .

Side effects

Usually the drug is well tolerated, but may occur and side effects:

• Nervous system - headache, bad mood, dizziness, tremors throughout the body;
• from respiratory - bronchospasm bronchospasm;
• from the gastrointestinal tract - poor appetite, abdominal pain Abdominal pain: Types and Symptoms , Inflammation of the mucous membrane of the mouth, abnormal liver function, inflammation of the intestines;
• the part of the blood, reducing the number of platelets (bleeding tendency), decreasing the number of leukocytes (lowered immunity), anemia;
• From the urinary system - renal dysfunction, release of large amounts of salts in the urine;
• on the part of the musculoskeletal system - pain in muscles and joints;
• allergic reactions - itching, rash, angioedema and other allergic reactions.