Trichopolum has special properties - when combined with alcohol it causes disulfiramopodobnye reactions - severe condition of the patient, at the same time causing an aversion to alcohol. Therefore Trichopolum Trichopolum - he treats?   It is used to treat patients suffering from chronic alcoholism.

What happens in the body when taken Trichopolum and alcohol

Trichopolum - a drug that has antiprotozoal and antibacterial activity. But at the same time it is used as a treatment for alcoholism.

Under normal circumstances, alcohol, getting into the body, quickly decomposed into non-toxic metabolic products (metabolites). When receiving certain medications decomposition of alcohol impaired. The classic formulation of this series is disulfiram (teturam, Antabuse, esperal), so the reaction while taking this drug called disulfiram and alcohol, alcoholic, and if disulfiram is used instead of another drug - disulfiramopodobnyh.

That is the reaction of alcohol while taking calls and Trichopolum. The appearance of this reaction caused by accumulation in the body of one of the products of metabolism of acetaldehyde alcohol, are highly toxic. Under normal circumstances, acetaldehyde is rapidly inactivated by the enzymes (aldehyde and some other). But Trichopolum inhibits the action of these enzymes and toxic acetaldehyde accumulates in the body, causing a number of characteristic symptoms.

In addition, Trichopolum and products of its metabolism inhibit the action of certain enzymes further, resulting in central nervous system, reduced levels of norepinephrine and the relationship between dopamine and noradrenaline, which further exacerbates the symptoms disulfiramopodobnyh reaction.

These properties allow the use Trichopolum for the treatment of patients with chronic alcoholism: if the patient is at least once moved disulfiramopodobnyh reaction, he has produced enough aversion to alcohol.

Symptoms disulfiramopodobnyh reaction

Disulfiramopodobnyh reaction appears while receiving Trichopolum and alcohol in the form of redness and a burning sensation in the face and upper torso. At the same time there is a feeling of tightness in the chest, shortness of breath, buzzing in the ears, decreased blood pressure Blood pressure - dangerous if his swing? , Palpitation, anxiety, feeling of "impending death", nausea Nausea - there may be problems with the nervous system , Vomiting

Duration and intensity of the reaction depends on disulfiramopodobnyh Trichopolum dose received and the number of alcohol. With the increase taken alcohol increases the duration and severity of its main manifestations, until the development of collapse - a sharp decline in blood pressure with loss of consciousness.

Treatment of patients with chronic alcoholism using drugs that can cause reactions disulfiramopodobnye

The history of the use of disulfiram for the treatment of patients with chronic alcoholism began with what has been observed decrease in drinking workers employed in the production of rubber. In the study it was found that the "originator" of this is disulfiram, which is used in production processes in the rubber industry.

This discovery led to the fact that disulfiram has been used to treat patients with chronic alcoholism. It later emerged that the same reaction can cause some drugs, for example, and furozolidon Trichopolum.

This helps patients to cope with a desire to drink at various stress and difficult situations that normally cause disruptions.

Trichopolum prescribe a course of ten days of one tablet (250 mg) twice a day. Such treatments can be carried out twice a year. But sometimes Trichopolum appointed and longer courses for several months. Of course, Trichopolum applies not alone, it is part of the comprehensive treatment of patients with chronic alcoholism.

Why can not apply concurrently with disulfiram Trichopolum

At simultaneous reception Trichopolum and disulfiram may develop sharp decline in blood pressure on a background of reducing the amount of norepinephrine in the central nervous system. It is also possible the development of consciousness disorders and acute psychosis.

Trichopolum - a drug that in no case can not be combined with alcohol.

Galina Romanenko

Vaccination mantle (right - Mantoux test) is done annually for all children in order to detect the early stages of tuberculosis. This test allows you to capture the moment of introduction into the body of the child Mycobacterium tuberculosis, which he develops an allergic reaction, and the development of his primary tuberculosis Primary tuberculosis - a negative contact with mycobacteria .

How to use vaccination Mantoux test can detect tuberculosis

Tuberculosis - a problem that still persists even in the most developed countries. But children in our country, tuberculosis is rare due to the timely detection and treatment of the bends - the initial introduction of the organism Mycobacterium tuberculosis. Penetrating into the body, the TB germs cause an allergic reaction. It is this allergy and identify Mycobacterium tuberculosis using Mantoux test - diagnostic allergy test, based on intradermal injection of tuberculin (product derived from Mycobacterium tuberculosis).

A similar sensitization (allergy) develops in response to vaccination against tuberculosis - BCG. Therefore, when assessing the Mantoux test is taken into account the time that has passed since the BCG.

Who, where and how to make the vaccination Mantoux

Mantoux test for the first time makes a child under the age of one year in order to find out whether he has immunity Immunity - types and characteristics in children in adults   after administration of BCG (vaccination against tuberculosis is carried out to all newborns in the hospital). Then the Mantoux test is conducted each year for all children, usually closer to the birthday.

Mantoux test done in the area of ​​the front surface of the forearm: a strictly intradermally administered 0, 1 ml (2 units TB - TE) tuberculin. Performance is measured through the third day, that is 72 hours. Before testing is necessary subsequent to the injection site is not injured and not combing, so the child is better to wear long-sleeved clothing. It is impossible to seal the injection site with an adhesive plaster, etc. perebintovyvat - It injures the skin and can change the results of the reaction. It is not necessary to bathe the child and simply wet with water or anything to lubricate the place where was made the Mantoux test. After checking the Mantoux test your doctor if the wound is inflamed or festering badly, it can be treated by any means.

The response to vaccination Mantoux - what she says?

After 72 hours after setting the Mantoux test at the injection site may occur a slight thickening of the skin - a papule. That it is measured and evaluated. In order not to confuse the papule with reddening of the skin, press down on it with your finger or a transparent ruler - papule becomes white and has a clear edge. Measure the transverse dimension of the papules without taking into account its surrounding redness. Redness is recorded only if there is no papules.

Evaluation of the results:

• Negative Mantoux test - the complete absence of papules or papule no more than 1 mm.
• Doubtful Mantoux test - papule measuring 2-4 mm, or only redness any size without papules.
• A positive Mantoux test - papule size of 5 mm or more. Weakly positive Mantoux test - papule measuring 5-9 mm, medium intensity - 10-14 mm, expressed - 15-16 mm hyperergic (very severe) - in children and adolescents - 17 mm or more in adults - 21 mm and more . Hyperergic or vesicles, necrotic considered as a reaction at the injection site when formed pustules and necrosis of tissue sites of any size, inflammation of lymphatic vessels or lymph nodes surrounding the increase Lymph nodes - what keeps our immune system .

In addition, it considers how papule increased compared to last year. Increased infiltration by 5 mm or more for the year is considered to be growing reaction to the tuberculin.

After the introduction of infection into the body becomes TB-infected child - nothing unusual in this state is not present, all TB-infected adults. But under adverse conditions (fatigue, malnutrition, and so on), a child may develop TB Tuberculosis - a full recovery is not guaranteed .

Vaccination Mantu - contraindications for

Mantoux test can not be done if any disease that can cause confusion in the evaluation of the results are:

• any skin disorders on the inner surface of the forearm;
• any acute illness and exacerbation of chronic diseases;
• allergic diseases and reactions;
• epilepsy with frequent attacks that occur in response to any external influences (including injection);
• Quarantine in children's groups about any infection.

Vaccination Mantoux conducted a month after the child's recovery, removal or quarantine of any kind was a preventive vaccination.

Galina Romanenko

Vaccination Mantu - everything you wanted to know

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