The mechanism of action of tinidazole

Tinidazole - a drug that inhibits the activity of protozoa and bacteria, inhibiting the cells sensitive to the formation of microbial DNA it is easy to penetrate into the cells of infectious agents. It is active against Trichomonas vaginalis, amoeba dysentery, giardia. Suppresses reproduction (bacteriostatic effect), anaerobic (without developing air) bacteria - fuzobakterii, Clostridium, etc.

After oral tinidazole is rapidly absorbed into the blood, high blood concentration is achieved in two hours. It penetrates the tissues and body fluids (including cross the placenta of a pregnant woman to the fetus), and then enters the liver, and there is decomposed in approximately 14 hours with urine and feces. Tinidazole can also be allocated to human milk.

In some cases, appointed tinidazole

Tinidazole has the following indications:

• trichomoniasis in women and men;
• all forms of amoebic dysentery;
• giardiasis (if you have any of its manifestations);
• bacterial infections caused by anaerobic bacteria (after microbiological analysis);
• condition after the operation - to prevent suppurative complications caused by anaerobic bacteria;
• infections caused by anaerobic and aerobic (which develop only under air) bacteria; in such cases, tinidazole combine with antibiotics acting on aerobic microflora;
• gastric ulcer or duodenal ulcer caused by Helicobacter pylori (in the complex treatment).

Contraindications to the use of tinidazole

Contraindications Tinidazole is an individual intolerance of components, injuries and diseases of the central nervous system, diseases of the blood. Tinidazole is contraindicated in the first 12 weeks of pregnancy and breastfeeding Breast-feeding: feed - and no nails!   Child (excreted in human milk). After 12 weeks of pregnancy, the drug should be taken with caution, and only on prescription. Not established the safety and efficacy of tinidazole for children under 12 years.

Possible consequences

In the treatment of tinidazole may be some side effects:

• the part of the digestive system: loss of appetite, nausea, vomiting, dry and metallic taste in the mouth, diarrhea;
• the central nervous system: weakness, headache, dizziness Dizziness - if the ground is slipping from under his feet , Gait disturbance, seizures (in this case override tinidazole); In this regard, during the treatment is not recommended tinidazole driving transport and other activities that require attention;
• with a side of blood: reducing the number of white blood cells (leukocytes), which have the function of protecting the body from infection; In this regard, while taking tinizazola over 6 days, you must do a complete blood count;
• an allergic reaction: hives (drain, towering above the skin rash), itching, angioedema (swelling of the face, which goes to the larynx may be the cause of suffocation);
• while taking tinidazole and alcohol may cause the so-called antabusopodobnoy reaction tinidazole blocks the enzyme aldehyde dehydrogenase, which is why when taking alcohol in the body accumulates toxic acetaldehyde, there is a feeling of fear, chills or fever, difficulty breathing, increased heartbeat, a feeling of lack of air, drop in blood pressure Blood pressure - dangerous if his swing? , Uncontrollable vomiting.

Tinidazole is compatible with antibiotics Antibiotics - whether they will help you in the foreseeable future?   and sulfanilamidnymi drugs. It is not necessary to combine it with taking certain drugs that reduce the rolling properties of the blood (anticoagulants).

As used tinidazole

Tinidazole is available in tablets that are taken orally during or after a meal. Trichomoniasis, giardiasis, and for the prevention of postoperative complications once it is taken, with amoebic dysentery - within two or three days, amebiasis of the liver - up to six days.

When treating bacterial infections it is prescribed in smaller doses, but for a longer time (up to five or six days).

Tinidazole has a broad spectrum of activity against protozoa, as well as agents inhibit the development of some bacterial infections. But as with any effective medication, it has contraindications for use and should be used only on prescription.

  Galina Romanenko

Nail fungus and its causes

Nail fungus is called onychomycosis. Parasitic fungi affecting the skin and its appendages (hair and nails), fungi called dermatophytes (dermatomitsetami).

Fungus, getting on the skin can be a, sometimes for a long time to be there without causing disease. But with the appearance of predisposing conditions (wearing tight or not breathable shoe, moist environment, nail trauma, reducing the body's defenses), he begins to actively multiply and cause disease.

Infected nail fungus can be in the pool, the sauna, the gym and so on, in contact with skin or clothing and footwear of the sick person. This initially affected skin and then its appendages (nails).

Signs

It starts usually in the defeat of the free edge, at the side edges or at the bottom (bed) nail. Sometimes the nail is affected all at once. Patients nails change shape, color (made dull, yellow), thicken, then stratify and crumble. First, the fungus affects one nail, then spread further or remained unchanged over the years.

Because of the enhanced keratinization nail bed is the destruction of the nail, especially laterally. Gradually, this process leads to separation and shrinkage (dystrophy) of the nail: it gradually loses its luster, becomes dull, thickens and changes its shape and color. The color change is as follows: first appear on the nail spots and stripes, then the entire nail changes color, getting the color from white to brown-black, it becomes opaque.

Diagnostics

Nail fungus is a typical manifestation, so its diagnosis is not difficult. To confirm the diagnosis carried out laboratory research scraping with modified skin. Detection of fungi in scrapes allows to establish a definitive diagnosis of nail fungus.

The fungus can be found by PCR - detected the DNA of the infectious agent.

Treatment for nail fungus

Complex treatment of nail fungus, which includes a general treatment (strengthening the body's defenses), the use of antifungal drugs, drug improves blood circulation and local treatment of the affected nails and skin.

General treatment to strengthen immunity Strengthening the immune system - help the immune system   - A healthy lifestyle, regular intake of vitamin-mineral complexes, if necessary - drugs that stimulate the immune system.

Currently, there are antifungal agents (e.g., griseofulvin) which can completely release the body from the mold, and they not only kill the fungus, but also stimulates the growth of the nail plate as well as a time delayed in the nail that is the prevention of disease recurrence. But it is quite toxic drugs, they usually have a lot of contraindications, as well as the need to take them for a long time (at least 2 months), the reception of them without a doctor's prescription should be completely excluded.

There are also a variety of drugs for local treatment, it is ointments, creams, lacquers, means softening horny masses and provide access to the affected tissues. For processing hardware nails there are devices with special cutters polish that safely clean off excess horny layers and thickening of the nail occurring fungal diseases. Some local products enough to put on nails 1-2 times a week.

In some cases, may help people's money. For example, is daily put a small towel dampened with a 20% propolis tincture Propolis tincture: obvious use   (in pharmacies) to the affected nail fungus and kept for 20 minutes. After some time, the affected nail is gone, and in its place will grow healthy.

Prevention of recurrence of nail fungus

During treatment is required at least once a month to handle contaminated items, including shoes, floors, as well as all the items in the house, which could survive the fungus. For this purpose, a solution of acetic acid or formalin: cloth soaked in the solution, put shoes pre-treated insole, then shoes tightly closed in a plastic bag for a day.

To prevent nail fungus need to wear loose shoes, personal hygiene, nail care and skin of the feet. In addition, we must remember that to enter such public places as baths Sauna and health: the benefits and harms of bath procedures , Saunas and swimming pools to personal shoes

And remember that nail fungus is most often combined with impaired immunity Immunity - types and characteristics in children in adults And therefore require inspection.