- Primary amenorrhea - a consequence of a genetic "damage"
Primary amenorrhea - is the absence of menstruation in women older than 16 years. Amenorrhoea is combined with infertility. In the case of primary amenorrhea infertility can carry genetic nature and be combined with various other anomalies, as well as developmental disorders.
Primary amenorrhea - the causes of
Menstrual cycle and its characteristics
by type of primary amenorrhea can occur at any level of neurohormonal systems - the cerebral cortex - the hypothalamus - pituitary - ovary. In addition, "breaking" may be at the level of the uterus, in that case would be considered primary amenorrhoea false as neurohumoral system will not be activated.
The most common cause of primary amenorrhea are genetic disorders (chromosomal abnormalities) that affect the condition of the ovaries. Each person has a set of 46 chromosomes (23 pairs). The 23rd pair of chromosomes - is the sex chromosomes in women is two X chromosomes, and males - XY. To female reproductive system to function properly in the 23rd pair must have two X chromosomes. If this policy is somehow broken, then there are violations, including developing primary amenorrhea. In some genetic disorders (for example, in Turner syndrome) egg in the ovaries are replaced by connective tissue and restore them is not possible.
Sometimes primary amenorrhea is the consequence of serious illness or intoxication suffered by a girl in utero or in early childhood. This also kills ovarian oocyte and replaced by connective tissue.
The blood of these girls found very low levels of female hormones and high levels of pituitary gonadotropins (pituitary struggling to stimulate ovarian function, but it does not work). Such species are called primary amenorrhea hypergonadotrophic.
The cause of primary amenorrhea may also be the defeat of the hypothalamus that evolved with severe physical and neuropsychiatric load and stress and poor nutrition among adolescent girls. Such amenorrhea
The absence of menstruation (amenorrhea) - ambiguous symptom
called the center, as a rule, it is a functional one, and with proper treatment runs independently. Sometimes the cause of primary amenorrhea are tumors and diseases of the hypothalamus and pituitary gland. This is a violation of development the hypothalamic gonadotropin-releasing hormone, which leads to a suppression of the secretion of pituitary gonadotropins (TG), as well as this there will be no ovarian stimulation
Ovarian stimulation: if you want to get pregnant
To fall and the content of female hormones. And this, in turn, is often accompanied by increased secretion of male sex hormones and promotes the emergence of virilnogo syndrome (increased body hair, changes in the figures for male pattern), moderately expressed in the hypothalamus-pituitary disorders.
Primary amenorrhea is called false in case neurohormonal system is functioning normally, but there is no menstruation because of the obstacles to the outflow of menstrual blood. This happens, for example, when there is no hole in the hymen.
The main symptoms of primary amenorrhea
Since the primary amenorrhea may develop on the background of various diseases and conditions, their signs may also be different. For example, the central (hypothalamic) amenorrhea usually manifests itself only in the absence of monthly, but the long flowing hypothalamic amenorrhea body and face girl gradually undergoes characteristic changes: weight increases, fat is stored mainly in the abdomen, pelvis, hips and breast. The face becomes round, soft leather, with a marble shade, pubic hair and armpits rare or completely absent. External genitals are usually underdeveloped, narrow vagina, the uterus is too small.
Severe genetic abnormalities in the ovaries are usually combined with the general underdevelopment. For primary amenorrhea is of genetic origin, such as Turner syndrome Shershnevskoye, when the primary defect in ovarian tissue develops due to genetic damage. Girls with Turner syndrome are short stature, short neck, the predominance of the lower half of the body over the top. Secondary sexual characteristics are poorly developed, osteoporosis
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(brittle bones associated with calcium deficiency). Sometimes these symptoms are combined with other severe anomalies.
An experienced doctor after the questioning and examination of the girl is about, the cause of primary amenorrhea. To confirm the diagnosis, the girl takes blood on hormones, hormone tests are carried out when using a specific hormone stimulated by a particular segment of the neurohormonal system - it allows you to more accurately determine exactly where the violation occurred.
Held as ultrasound pelvic X-ray and magnetic resonance imaging of the brain, if necessary - endoscopic examinations.