Ketorol - a powerful anesthetic drug that belongs to the non-steroidal anti-inflammatory drugs (NSAIDs). It helps with pain of different origin from dental and head to severe pain on the background of trauma and cancer.
All NSAIDs have anti-inflammatory, analgesic and antipyretic properties. But each individual product has its own "specialty". Thus ketorol is mainly analgesic, antiinflammatory and antipyretic action in a much less pronounced.
The mechanism of action ketorol
Ketorol mechanism of action is based on the fact that it inhibits the action of an enzyme which participates in the formation of prostaglandins - complicated biologically active substances that cause an inflammatory reaction.
But prostaglandins inter alia also protects the gastric mucosa from various adverse effects. Therefore, after blocking their activity can result in various side effects from the gastrointestinal tract, from simple irritation to erosive and ulcerative processes.
Another side effect of the drug is that it affects the blood, reducing the number of blood platelets. This feature, combined with erosive and ulcerative lesions of the stomach and intestines can cause gastrointestinal bleeding. In addition, ketorol can cause nasal, uterine bleeding
Uterine bleeding outside of menstruation - a sign of a serious breach
, Bruising with small injuries.
Application ketorol
Apply ketorol with moderately severe and severe pain of various origins. But more often it is pain that occurs on a background of injuries (severe injuries, fractures, sprains
Dislocation - Prevention and Treatment
, Cut and gunshot wounds), burns, frostbite with tissue necrosis or postoperative pain (before the surgery was not used because of the risk of bleeding.
Apply ketorol and such chronic diseases that are accompanied by severe constant pain. For example, in rheumatoid arthritis, ankylosing spondylitis
Ankylosing spondylitis - a lot of patience is required
, Osteochondrosis. But in these cases ketorol try to use a short course, and only during the acute inflammatory process.
Ketorol can be used for pain of any origin. For example, in dental pain, including during dental treatment. Short course ketorol also can be administered with strong pains during menstruation, pain in the ear, infringement and inflammation of the peripheral nerves.
Contraindications in the appointment ketorol
Ketorol appointment is contraindicated in various diseases of the stomach or intestines, especially if they had been accompanied by bleeding, with blood clotting, bleeding is suspected in any field at a hemorrhage in the brain (hemorrhagic stroke), which is characterized by the violation of the integrity of a cerebral blood vessel. Since the bulk of ketorol eliminated via the kidneys, its reception is contraindicated in violation of renal function.
Ketorol may cause allergic reactions, however it is contraindicated in cases where there is an allergy to some NSAIDs, and are hypersensitive to the drug itself.
Ketorol contraindicated in pregnancy, during birth and during breast-feeding
Breast-feeding: feed - and no nails!
child. In pregnancy it can have a negative impact on the fetus and during labor - affect the duration of the first stage of labor or labor under the influence of ketorol contractions become shorter and sparse. Ketorol may also inhibit the contractility of the uterus and the fetal circulation.
Ketorol should be used with caution:
- for violations of liver and kidney function;
- in chronic cardiovascular disease, high blood pressure;
- when erosive and ulcerative lesions of the stomach and intestines in remission, as well as if the past were gastrointestinal bleeding;
- in elderly patients - the dose should be lower than that of younger patients.
If signs of liver function abnormalities (jaundice), skin rash, increased number of eosinophils in the blood ketorol to cancel.
During treatment ketorol may appear side effects such as headache, dizziness, insomnia, mood changes, and therefore at this time it is not recommended to engage in potentially hazardous activities that require increased attention and psychomotor speed reactions, for example, to drive a car.
Ketorol not combined with all medications. So, when concomitantly with other NSAIDs or anticoagulants (drugs to lower rolling capacity of the blood) may cause bleeding, some drugs that lower blood pressure (ACE inhibitors) - renal dysfunction, with some diuretics, such as furosemide, - reduction of its diuretic action.
Ketorol - NSAID with pronounced analgesic properties.
Galina Romanenko