Nimesil gives significantly fewer side effects than conventional non-steroidal anti-inflammatory drugs (NSAIDs). However, such effects occur, especially in people with some comorbidities nemisil therefore not suitable for all patients.
Contraindications nimesil on the part of the gastrointestinal tract
The mechanism of action of NSAIDs is based on the fact that they inhibit the synthesis of biologically active substances - prostaglandins by inhibiting enzymes involved in their synthesis. Prostaglandins play a major role in the human body and perform a variety of functions. In particular, they form an inflammatory response - it is their property and try to suppress using NSAIDs.
But prostaglandins also protect the gastric mucosa against various impacts and inhibition of this property causes different reaction from the gastrointestinal tract. Nimesil the latest generation of NSAIDs, which inhibit the action substantially only enzymes that affect the synthesis of prostaglandins involved in inflammatory processes. But to completely eliminate its effect on the synthesis of prostaglandins is impossible, so the side effects (though to a much lesser extent) are stored.
Nimesil can be taken in certain diseases of the gastrointestinal tract without exacerbation, but diseases such as gastric ulcer and duodenal ulcers, erosive (Surface impaired mucosal integrity), gastritis, ulcerative colitis (inflammation of the colon) in the acute stage is Contraindications this drug.
Contraindications nimesil of the liver and biliary tract
Nimesil can have toxic effects on the liver cells, so it is very rare, but do occur cases of toxic hepatitis
Toxic hepatitis - the impact of harmful substances on the liver
Which can take place very quickly, and even lightning. In other cases, perhaps a little abnormal liver function, which results in an increase in liver enzymes.
May cause nimesil and stagnation of bile in the biliary tract (cholestasis), sometimes accompanied by the yellowness of the skin and mucous membranes.
Therefore, for any active liver disease nimesil contraindicated. It can not be also used in conjunction with other drugs having hepatotoxic properties (toxic effect on the liver cells), such as paracetamol. Nor during treatment nimesilom drinking alcohol, which has a direct toxic effect on the liver cells.
Contraindications nimesil in the blood
Nimesil promotes blood oppression. Reduced number of red blood cells (which can lead to anemia), white blood cells (low immunity) and platelets (the possibility of bleeding). The number of some types of white blood cells, in contrast, may increase, such as eosinophils - it says allergization body.
Therefore nimesil prescribed with caution for people who have a bleeding tendency, including, if the patient suffered a hemorrhagic stroke. You can not apply it after coronary artery bypass surgery and diseases accompanied by bleeding disorders.
Other contraindications for receiving nimesil
Nimesil contraindicated in severe heart failure and renal failure, as it is excreted in the urine and renal impairment may be retained in the body. In heart failure, it is delayed in the body fluid, which may also lead to an overdose of the drug.
Contraindications for use nimesil are also allergic to aspirin and other NSAIDs, such as urticaria, angioedema, bronchoconstriction, allergic rhinitis.
Do not use nimesil as an antipyretic agent in infectious and inflammatory diseases are hypersensitive to the drug, pregnancy and nursing
Breastfeeding - a personal choice
chest and under the age of 12 years.
Alcoholism, drug and substance abuse
Substance abuse - as a child back to life?
as a contraindication for receiving nimesil because of violations of the liver.
Be careful when assigning nimesil high blood pressure, diabetes mellitus
Diabetes - threatening and incurable disease
Type 2, coronary heart disease, cerebrovascular disorders - all violate the disease condition of the walls of blood vessels. Nimesil reduces the clotting ability of the blood and, therefore, increases the risk of hemorrhage in violation of the integrity of the vessels.
Since nimesil can cause dizziness and drowsiness, it is better not to take the performance of work requiring high concentration (for example, when driving a car).