Nimesil gives significantly fewer side effects than conventional non-steroidal anti-inflammatory drugs (NSAIDs). However, such effects occur, especially in people with some comorbidities nemisil therefore not suitable for all patients.

Contraindications nimesil on the part of the gastrointestinal tract

The mechanism of action of NSAIDs is based on the fact that they inhibit the synthesis of biologically active substances - prostaglandins by inhibiting enzymes involved in their synthesis. Prostaglandins play a major role in the human body and perform a variety of functions. In particular, they form an inflammatory response - it is their property and try to suppress using NSAIDs.

But prostaglandins also protect the gastric mucosa against various impacts and inhibition of this property causes different reaction from the gastrointestinal tract. Nimesil the latest generation of NSAIDs, which inhibit the action substantially only enzymes that affect the synthesis of prostaglandins involved in inflammatory processes. But to completely eliminate its effect on the synthesis of prostaglandins is impossible, so the side effects (though to a much lesser extent) are stored.

Nimesil can be taken in certain diseases of the gastrointestinal tract without exacerbation, but diseases such as gastric ulcer and duodenal ulcers, erosive (Surface impaired mucosal integrity), gastritis, ulcerative colitis (inflammation of the colon) in the acute stage is Contraindications this drug.

Contraindications nimesil of the liver and biliary tract

Nimesil can have toxic effects on the liver cells, so it is very rare, but do occur cases of toxic hepatitis Toxic hepatitis - the impact of harmful substances on the liver Which can take place very quickly, and even lightning. In other cases, perhaps a little abnormal liver function, which results in an increase in liver enzymes.

May cause nimesil and stagnation of bile in the biliary tract (cholestasis), sometimes accompanied by the yellowness of the skin and mucous membranes.

Therefore, for any active liver disease nimesil contraindicated. It can not be also used in conjunction with other drugs having hepatotoxic properties (toxic effect on the liver cells), such as paracetamol. Nor during treatment nimesilom drinking alcohol, which has a direct toxic effect on the liver cells.

Contraindications nimesil in the blood

Nimesil promotes blood oppression. Reduced number of red blood cells (which can lead to anemia), white blood cells (low immunity) and platelets (the possibility of bleeding). The number of some types of white blood cells, in contrast, may increase, such as eosinophils - it says allergization body.

Therefore nimesil prescribed with caution for people who have a bleeding tendency, including, if the patient suffered a hemorrhagic stroke. You can not apply it after coronary artery bypass surgery and diseases accompanied by bleeding disorders.

Other contraindications for receiving nimesil

Nimesil contraindicated in severe heart failure and renal failure, as it is excreted in the urine and renal impairment may be retained in the body. In heart failure, it is delayed in the body fluid, which may also lead to an overdose of the drug.

Contraindications for use nimesil are also allergic to aspirin and other NSAIDs, such as urticaria, angioedema, bronchoconstriction, allergic rhinitis.

Do not use nimesil as an antipyretic agent in infectious and inflammatory diseases are hypersensitive to the drug, pregnancy and nursing Breastfeeding - a personal choice   chest and under the age of 12 years.

Alcoholism, drug and substance abuse Substance abuse - as a child back to life?   as a contraindication for receiving nimesil because of violations of the liver.

Be careful when assigning nimesil high blood pressure, diabetes mellitus Diabetes - threatening and incurable disease   Type 2, coronary heart disease, cerebrovascular disorders - all violate the disease condition of the walls of blood vessels. Nimesil reduces the clotting ability of the blood and, therefore, increases the risk of hemorrhage in violation of the integrity of the vessels.

Since nimesil can cause dizziness and drowsiness, it is better not to take the performance of work requiring high concentration (for example, when driving a car).

Galina Romanenko

Don - a drug that has a positive effect on the articular cartilage, suspends its destruction, strengthens, prevents the development of osteoarthritis and reduces inflammation in the joint. It is used to treat osteoarthritis of different localization.

The mechanism of action of Dona

Don (Active ingredient - glucosamine) refers to a group of drugs - stimulants metabolism Metabolism: The basis of life of all living things   in cartilage. Available Don Italian pharmaceutical company Rottafarm bags with powder for oral solution and as a solution for intramuscular injection in ampoules of 2 ml (as an auxiliary substance in the vial contains anesthetic lidocaine) together with the solvent.

The mechanism of action of Dona based on the fact that glucosamine is a natural component of joint cartilage, it is always there in the human body. This substance is a low molecular weight, small amounts of it is contained in the food and have particular affinity for the cartilage. Cartilage cells used for glucosamine synthesis of biologically active substances that provide normal structure and strength of the cartilage its ability to withstand pressure, part of the synovial fluid - "lubricant" joints. Glucosamine also promotes the growth of connective tissue ligaments and tendons of the joints.

The lack of glucosamine in the body Glucosamine - a building material of an organism Particularly at high physical exertion and after the age of forty years, it may cause disorders of joints and, respectively, their functions. Medicinal products containing glucosamine (including Don), make up its deficiency in the body, prevent the destruction of cartilage, and if the process has already started the destruction of cartilage, helps to restore cartilage.

In general, Don has hondroprotektivnoe (protects the cartilage), anabolic (promotes restoration of cartilage tissue), anti-inflammatory and analgesic properties. It helps to restore cartilage, strengthens the connective tissue, improves the formation of synovial fluid. Don normalizes the enzymatic processes in the cells of the synovial membrane and cartilage tissue, prevents the development of degenerative (metabolic) disorders of the joints, and osteoarthritis Osteoarthritis - take care of the joints healthy longer It restores the normal operation of the joints, removes or reduces joint pain and. The improvement comes just two weeks after the start of treatment Dona, the maximum effect is achieved after a sufficiently long course of treatment (one - one and a half months) and stored for a further two months after treatment.

Indications and contraindications for appointment

Indications for use dons are:

• metabolic disorders in a variety of joints (osteoarthritis), including osteoarthritis of the knee, hip and other joints;
• chondromalacia patella - a softening of the cartilage under the kneecap;
• frozen shoulder - inflammation, thickening and contraction of the capsule that surrounds the shoulder joint.

Don taken orally or injected intramuscularly daily for a long time, up to four to six weeks.

Contraindications to the appointment of Dona are:

• phenylketonuria - a hereditary disease associated with the violation of protein metabolism, and cause severe changes in the central nervous system in this disease is contraindicated Dona reception inside in the form of a powder, as the excipient it contains aspartame, which can not be taken at phenylketonuria;
• heart block and severe congestive heart failure - intramuscular dons, as it is composed of lidocaine;
• Dona intramuscular administration is contraindicated also in epilepsy and seizures of unknown origin in a patient in the past, children under twelve years of age, during pregnancy and nursing Breastfeeding - a personal choice   feeding (adequate clinical trials data of patients were not carried out);
• idiosyncrasy components dons.

Side effects

In the treatment of the bottom, the following side effects:

• gastro-intestinal bloating, diarrhea, or constipation;
• Allergic reactions can manifest urticaria, angioedema, pruritus;
• Dona intramuscular injection may cause side effects of lidocaine - headache, dizziness, nausea, vomiting, lethargy and sleepiness, double vision, numbness of the tongue and oral mucosa, tremors, elevated mood, heart disorder.

Don - is an effective and safe drug for the treatment of diseases of the joints.

Galina Romanenko