Nimesil - this fine granules for oral administration. The granules contained in a sachet, typically dissolved in half a glass of water and taken after meals as an anti-inflammatory and analgesic. Nimesil can help with pain of different nature, but more often it is used for pains in the joints.

The mechanism of action nimesil

Nimesil (international non-proprietary name of nimesulide) - preparation of a new generation of nonsteroidal anti-inflammatory drugs (NSAIDs), which produced the well-known German pharmaceutical company Berlin-Chemie. Nimesil selectively inhibits the action of the enzyme cyclooxygenase II (COX-II). The enzyme cyclooxygenase (COX) is found in the body in two forms - COX I and COX II. Thus COX-I protects the gastric mucosa from any impacts, and COX-II is the development of inflammatory reactions. Existing before NSAIDs inhibited both types of COX that the negative impact on the gastric mucosa. Particularly affected patients are forced to receive NSAIDs for a long time.

Nimesil is also able to reduce the increased blood clotting and thrombus formation, reduce the symptoms of inflammatory and allergic reactions by inhibiting the action of biologically active substances that contribute to their development.

After oral granules nimesil well absorbed in the intestine and enter the bloodstream quickly, and from there to the tissues and organs. Nimesil maximum concentration in blood is reached after half an hour after ingestion.

Indications and contraindications for receiving nimesil

Nimesil apply:

• as an anesthetic with pronounced pain in the joints, including inflammation (eg rheumatoid arthritis) and degenerative distrficheskogo (exchange, such as age-related changes in the joints - arthritis) nature;
• as an anesthetic in inflammation of the tendons and synovial joints as a result of diseases and injuries;
• as an anesthetic after surgery and injuries;
• as an analgesic, anti-inflammatory agent in diseases of the ENT (for example, pain in the ear), dental (dental pain) and gynecological (painful menstruation) diseases;

Application nimesil contraindicated:

• if in the past, this patient had an allergic reaction or liver dysfunction drugs of any nonsteroidal anti-inflammatory drugs, including nimesil;
• in case of hypersensitivity to the drug;
• while the application of any other drugs that have toxic effects on the liver, and alcohol;
• in inflammatory processes in the intestine in the acute stage (for example, ulcerative colitis);
• after coronary artery bypass surgery (postoperative);
• at a fever associated with infectious and inflammatory diseases;
• when combined with bronchial asthma nasal polyps, and intolerant of aspirin and other nonsteroidal anti-inflammatory drugs (including the last);
• gastric ulcer and duodenal ulcer;
• in violation of blood clotting and increased bleeding;
• with severe diseases of internal organs with disorders of function (cardiovascular, renal, hepatic failure);
• the abuse of alcohol, psychotropic drugs or narcotics;
• Pregnancy and breast-feeding Breast-feeding: feed - and no nails!   Child;
• under the age of twelve.

Precautions nimesil prescribed for high blood pressure, diabetes, coronary heart disease, atherosclerosis, peripheral arterial disease (eg occlusive disease), smoking and old age.

Side effects that may occur while taking nimesil

In the application may experience the following side effects:

• From hemopoiesis system: decrease in the number of red blood cells and hemoglobin (anemia), and platelets (bleeding); increase of eosinophils (a tendency to allergic reactions);
• delayed allergic reaction (itching, rash, dermatitis) or immediate (urticaria, angioedema, anaphylactic shock) type;
• the central nervous system: dizziness, headache, lethargy, increased anxiety Anxiety - how to distinguish normal from disease? ;
• by the organs of vision - blurred vision;
• the part of the circulatory system - high blood pressure, tachycardia Tachycardia - the body to the limit? ;
• by the bronchopulmonary system - shortness of breath, worsening of asthma, bronchospasm;
• from the gastrointestinal tract - nausea, vomiting, diarrhea or constipation, gas in the intestines, stomach pain Abdominal pain: Types and Symptoms , Inflammation of the oral mucosa, gastrointestinal bleeding, severe liver disease;
• by the kidneys and urinary tract infections - painful urination, blood in the urine, urinary retention;
• General disorders - malaise, low temperatures, high levels of potassium in the blood.

Galina Romanenko

Joint inflammation is the body's response to various diseases or irritants. Its causes may be, for example, injuries, including fractures and deep cuts, which resulted in the infection of the joint can occur by bacteria or viruses. However, the most common cause of arthritis is the inflammation of the joints Arthritis - a variety of forms and complications . The body responds to this condition by increasing the blood flow to the affected joint. White blood cells and certain chemicals found in the blood and cause inflammation of the joints.

Diseases that can cause inflammation of the joints

The most common type of arthritis, which often causes inflammation of the joints is osteoarthritis. In this disease on the bones in the joints formed small processes, which cause irritation and inflammation of the surrounding muscle tissue, tendons, and ligaments.

Gout - another type of arthritis. It causes inflammation of the joints that can last for weeks. Often, the inflammatory process is concentrated in the big toe joint. The cause of inflammation are uric acid crystals that accumulate in the joints, like shards of glass. Gout develops when the body can not be processed protein called purine, resulting from an excess of uric acid which is formed. In some cases, gout is inherited; in others it is a side effect of various medications.

Third, and much less common form of arthritis that causes inflammation of the joints - is rheumatoid arthritis Rheumatoid arthritis - when the sore joints . It refers to autoimmune diseases - in these disorders the body's immune system reacts to the healthy tissue as it normally responds to infection. In rheumatoid arthritis, the immune system "attacks" on the joints.

Lupus - another autoimmune disease that can lead to inflammation of the joints.

Some infections, such as tick-borne Lyme disease also causes inflammation of the joints.

Much less of the above conditions causes inflammation of the joints are diseases such as polymyalgia rheumatica, and ankylosing spondylitis.

Treatment

For example, in Lyme borreliosis need treatment with antibiotics, and rheumatoid arthritis are sometimes appointed by the administration of drugs that suppress the immune system.

When gout is recommended to drink plenty of water (which is washed out of the body uric acid) and limit the intake of purines. Particularly rich in purine meats and seafood.

Against inflammation of the joints in other types of arthritis can help warm moist compresses or moderate physical activity.

Anti-inflammatory drugs are also effective in relieving symptoms, but they have a long list of side effects that often occur during long-term treatment.

Signs of inflammation of the joints

The main signs of joint inflammation are pain in the joints Joint pain - how to understand what is going on? Swelling, redness of the skin over the joint, change its shape, rise in temperature of the skin of the diseased joint and impaired function.

The pain in inflammation of the joints has the characteristic features, it is called - "inflammatory." Inflammatory pain occur suddenly, usually in the second half of the night or in the morning and decrease after the beginning of the movement. If the inflammation is acute, pain more severe and persistent, chronic pain appears during mostly in motion.

Sick joint changes its shape due to the swelling of the soft tissues, arising on a background of persistent inflammation of the muscles and tendons of information (contractures) and partial exits from joint acetabulum (subluxation).

Employment of the joint is broken from both of sharp pain, and because of changes in the tissues surrounding the joint. In some arthritic disorders of the joint can be so severe that the joint becomes immobile and the patient is completely deprived of the opportunity to engage in employment. At the same time in other types of arthritis-resistant limitation of movement may not occur and joint function after treatment is completely restored.

The course and complications of arthritis

Inflammation of the joints can occur acutely, subacute and chronic. Acute forms of arthritis usually occur fairly quickly and end in complete recovery with the restoration of joint function. Since flows, for example, rheumatoid arthritis. When this long, progressive chronic inflammation of the joints may occur complete loss of joint function with the patient's disability. This happens, for example, rheumatoid arthritis.

The early complications include various festering soft tissue surrounding the joint, for example, abscess (abscess is not limited to the capsule). By late complications include inflammation of the transition to the bones forming the joint (osteomyelitis), blood infection, a persistent reduction in violation of the joint (sometimes pronounced) of his work, sprains Dislocation - Prevention and Treatment   and joint subluxations (complete or incomplete output of the joint head of the glenoid fossa).

Diagnostics

As the inflammation of the joints may be a sign of another no less serious illness, a patient with arthritis fully examined, revealing the external signs of inflammation and correlating them with additional research (eg, X-ray) and laboratory testing of blood, urine and synovial fluid, confirming the presence of inflammation.

  Galina Romanenko