Acyclovir - a drug for the treatment of viral diseases. It is available in different dosage forms, so it can be used inside, intravenously, topically and locally. Acyclovir is prescribed for diseases caused by the herpes virus - herpes simplex
Herpes simplex - in fact, not so simple
, Genital herpes, chicken pox, shingles and others.
The mechanism of action of acyclovir
Acyclovir - is an antiviral drug that comes in tablet form for oral administration, a lyophilized (dried with the help of modern technology) powder for solution for injection in vials, 5% ointment for topical use, ophthalmic ointment 3% and 5% cream.
The mechanism of action of acyclovir is based on the fact that, under the action of the enzyme, which is produced only in the infected cells, it is converted to its active form - acyclovir triphosphate. Acyclovir triphosphate enters the infected cell and incorporated into the process of synthesis of viral DNA, thereby inhibiting its reproduction.
Acyclovir is a non-toxic drug, as it has no harmful effects on healthy cells that do not produce an enzyme to activate it. Its action is strictly selective - only for virus cells.
Show sensitivity to acyclovir herpes simplex viruses (including causing genital herpes) causes chicken pox and shingles
Ringworm - not only infectious disease
When skin manifestations of herpes acyclovir prevents the spread of the rash, it accelerates prisyhanie bubbles, reduces the risk of complications in the internal organs, reduces the pain of shingles, has an immunostimulatory effect.
Once inside absorbed about a fifth of the dose of acyclovir. It enters the brain and spinal cord, is excreted in human milk. Acyclovir is decomposed in the liver, and then is removed by the kidneys in unchanged form or in the form of metabolic products.
Indications and contraindications for use
Acyclovir is prescribed for the appearance of the earliest signs of the disease:
- for the treatment of primary and recurrent infections of the skin and mucous membranes, herpes simplex virus, such as genital herpes, and herpes of the lips, including immunocompromised patients after organ transplantation;
- for the treatment of chickenpox and shingles caused by herpes viruses;
- for the treatment of herpes infections of internal organs (encephalitis, pneumonia, and so on);
- for the treatment of herpes infections in newborns;
- for the treatment of herpetic eye disease (herpetic keratitis).
When acyclovir is recommended to drink more water - it will warn the deposition of salts in the kidneys (sand). The application of an ointment or cream is recommended to wear gloves to prevent the spread of the rash to other areas of the body.
Contraindications for the purpose of acyclovir is an idiosyncrasy of the drug and breast-feeding. When pregnancy acyclovir is assigned when the intended benefits to the woman's body than the potential risk to the body of the child.
Not recommended to prescribe acyclovir
Acyclovir - as it is safe?
with severe kidney disease in violation of their functions.
When the pill atsikolvira: nausea, vomiting, diarrhea, abdominal pain
Abdominal pain: Types and Symptoms
, Headache, dizziness, decreased performance and concentration, hallucinations, drowsiness or insomnia, mild fever, body rash, alopecia, transient effects on the liver and kidneys, reduced the number of blood leukocytes and erythrocytes.
With the introduction of acyclovir intravenously, general reactions: nausea, vomiting, acute renal failure due to deposition in the kidney tissue salt crystals, sand (salt crystals) in the urine, impaired consciousness, hallucinations, agitation, tremors, convulsive readiness, acute mental disorders (psychosis), drowsiness or insomnia, coma; at the site of injection: inflammation of the skin or the walls of the veins (phlebitis).
When topically applied acyclovir ophthalmic ointment: burning and itching at the site overlay ointment surface inflammation.
Prolonged external application: at the site of an ointment or cream burning, itching, rash, redness and dryness of skin peeling; on the mucous membranes - irritation, which is accompanied by burning and itching.
Signs of an overdose of acyclovir include nausea, vomiting, diarrhea, severe headache, dizziness, shortness of breath, acute renal failure, seizures, coma. When these signs need to call an ambulance: treatment should be carried out only in a hospital.
Acyclovir - a drug that has to appoint a doctor.