Domestic antiviral Kagocel - this is another weapon against viral infections, which are rampant in the late autumn, winter and early spring. According to preliminary estimates the drug has a good effect and is combined with other anti-viral diseases.

What Kagocel and who releases

Kagocel software developed by the pharmaceutical company "Niarmedik plus", established over twenty years ago on the basis of Institute of Epidemiology and Microbiology Gamaleya RAMS. Set up companies in order to introduce into clinical practice the results of its own, unparalleled research and techniques for the diagnosis, prevention and treatment of infections.

During its existence the company has established itself as a bona fide provider of quality goods, so the new Kagocel developed on its base, recommended by the Ministry of Health and Social Development of the Russian Federation for use in the prevention and treatment of acute respiratory viral infections and flu, as well as for the treatment of diseases caused by the herpes virus . To this end, the Health Ministry of the Russian Federation have developed special guidelines "Treatment and prevention of influenza caused by virus type A (H1N1) for adults." In addition, kogatsel was included in the approved list of vital and essential medicines that allowed to include it in the public procurement system.

How does Kagocel

Kagocel an inducer (increases the production), interferons, but almost not absorbed in the gastrointestinal tract (absorbed about twenty percent) as its basis is cellulose chemically firmly bound to the molecules of active substance her. As a result of Kagocel the body produces its own recent interferons (a mixture of alpha- and beta- interferons, which possess high antiviral activity) for a long time (up to five - to seven days). This allows you to apply Kagocel for the prevention of SARS and influenza in small doses and short courses at any stage of contact with the patient.

Kagocel stimulates the production of interferon Interferon - protects against diseases of the new century?   in all cells involved in antiviral immunity Immunity - types and characteristics in children in adults : T and B lymphocytes, macrophages, granulocytes, fibroblasts Fibroblasts: the mystery of the connective tissue , Endothelial cells. After oral administration of a single dose Kagocel amount of interferon in the blood increases significantly, reaching the largest numbers after 48 hours and then holds another two - three days.

In the process of preparation, as well as its further application was installed kogatsela good efficacy for the treatment of various viral infections (ARI, influenza, herpes Herpes - a virus creeping Including genital) when it completely safe and non-toxic.

Kagocel advantage is the high safety, no side effects (except for allergic reactions which can occur on any drug), common short reception circuit and the possibility of effective action at a relatively late timing of the start of reception (on the fourth day of the disease). Furthermore, the drug is not toxic and has no adverse effect on pregnant women and fetus, and not have oncogenic properties.

Kagocel disadvantage is that, apparently, were not carried out its clinical trials on pregnant women and children up to six years, with the result that the drug is not permitted to use these categories of patients.

As Kagocel excreted from the body

One day after the intake of Kagocel first begins to enter the bloodstream, and then to various organs and tissues, they accumulate in the liver, thymus, lung, spleen, kidney, lymph nodes. To a lesser extent Kagocel stored in adipose tissue, heart, muscle, brain (it hardly overcomes the blood-brain barrier, that is the penetration of the blood into the brain due to its high molecular weight). In the blood Kagocel is mainly in bound form (it binds to blood proteins and lipids), but some part of it (a little more than fifteen per cent) remain unbound. If you take Kagocel in accordance with the manufacturer's schemes, it accumulates in almost all organs, causing the desired therapeutic effect.

The bulk of the drug is excreted through the gastrointestinal tract, but a small part (about ten percent) eliminated via the kidneys. A week after the receipt Kagocel he appears almost ninety percent.

Kagocel issued on the basis of known in the Russian Scientific Research Institute of Epidemiology and Microbiology named after NF Gamalei RAMS, which allowed it to include in the List of Essential Medicines. However, the drug is not entirely finalized: not significant clinical trials conducted on all patients.

Galina Romanenko

Tsiprolet refers to a group of fluoroquinolones - drugs with a pronounced antibacterial effect, which, however, do not belong to the antibiotics. A distinctive feature of fluoroquinolones is that it is very rare to develop addictive microorganisms.

The mechanism of action tsiprolet

Tsiprolet (INN - ciprofloxacin) refers to a group of drugs, called fluoroquinolones. This artificial chemicals that can easily penetrate human tissue cells and microorganisms.

The mechanism of action tsiprolet (and all fluoroquinolones) based on inhibition of DNA gyrase products - the enzyme that is involved in the multiplication of bacteria. Action fluoroquinolones differs from the action of antibiotics, so often they are effective where there is already used without success, certain antibiotics.

Today produced four generations of fluoroquinolones, tsiprolet refers to the second generation of these drugs. The drug is available in tablets and has a strong bactericidal (kills the pathogens) action. For most species tsiprolet sensitive staphylococcus, streptococcus, E. coli. No sensitivity to tsiprolet in certain species of streptococci, as well as in Mycoplasma and Ureaplasma. Tsipolet activity against intestinal microflora. And another positive quality tsiprolet: addiction pathogens to it almost happens.

Tsiprolet smoothly absorbed in the intestine and enters the bloodstream first, and then in the tissue, mainly in inflammation, where there is more acidic environment than in other tissues. Because the body tsiprolet appears unchanged mainly via the urine.

Indications and contraindications for receiving tsiprolet

Tsipolet appointed after the establishment of the final diagnosis with determination to his susceptibility of infection. But in some acute diseases requiring emergency antibacterial therapy, a patient taking and analysis without waiting for the outcome, designate tsiprolet and after will result, if necessary adjusting treatment. Tsiprolet prescribed for the following infectious and inflammatory diseases:

• upper respiratory tract and the bronchopulmonary system - pharyngitis, bronchitis, pneumonia;
• Otolaryngology - angina, exacerbation of chronic tonsillitis, acute and chronic otitis, sinusitis, pharyngitis;
• Eye - purulent conjunctivitis, keratitis;
• kidney and urinary tract & - pyelonephritis, cystitis, urethritis;
• male and female sexual organs, including with gonorrhea;
• skin and subcutaneous tissue - abscess, phlegmon, boils, carbuncles, mastitis;
• musculoskeletal system - arthritis, osteomyelitis;
• gastrointestinal tract - acute gastroenteritis, enterocolitis;
• gallbladder and biliary tract - acute and chronic cholecystitis and cholangitis;
• in severe infections, complicated by sepsis (blood poisoning) and peritonitis (inflammation of the peritoneum - a thin film that lines the abdominal cavity);

Tsiprolet course of treatment must be accompanied by a large volume of liquid intake to prevent loss of insoluble salts in the urinary tract.

Tsiprolet should not be taken with the following diseases and conditions:

• hypersensitivity thereto patient;
• pregnancy and lactation;
• in childhood and adolescence;
• patients prone to the appearance of seizures of any origin;
• patients with severe injuries and tumors of the brain and spinal cord.

Side effects that occur while taking tsiprolet

When receiving tsiprolet may occur following side effects:

• the part of the circulatory system: tachycardia Tachycardia - the body to the limit? , Flushing, fainting;
• on the part of the stomach and intestines: violation of appetite, nausea, vomiting, diarrhea, abdominal pain Abdominal pain: Types and Symptoms , Flatulence;
• From the nervous system: fatigue, sleepiness, but sleep disturbance Dreams: how to understand our dreams   night; may occur, on the contrary, increased agitation, headache (including migraine type), tremor (shaking) of hands and feet, a violation of the sensitivity, increased sweating, loss of coordination, jerking, anxiety, depression Depression - a little more than a bad mood , Hallucinations, disturbances of vision and hearing;
• in the blood: anemia, increase in the number of eosinophils (allergic disposition), including a decrease of granular white blood cells (low immunity) and platelets (increased bleeding);
• Allergic reactions of immediate and delayed type;

During the course of treatment can not be engaged in work tsiprolet that require attention and coordination of movements, including driving motor vehicles.

Tsiprolet proven itself as an active antimicrobial agent.

Galina Romanenko