Sumamed and pregnancy: only in exceptional cases
January 8, 2012
Pregnant women are often faced with the necessity of taking any medication. Usually medicines prescribed by the doctor, taking into account the security of receiving them during pregnancy. Yet, according to some statistics, about eighty percent of pregnant women on their own and take prescribed different drugs without knowing what effect they may have on the fetus. But sometimes and gynecologists have to prescribe these drugs, which are capable of adversely during pregnancy. The need for the appointment of such drugs is justified by the potential benefit of treatment of the expectant mother, which exceeds the potential risk to the fetus.
Very often pregnant women are appointed antibiotics, which is associated with decreased immunity
Immunity - types and characteristics in children in adults
and development of various infections. However, not all antibiotics are allowed to take during pregnancy. It is still controversial question of the effect of the antibiotic Sumamed pregnancy.
Medication during pregnancy
If the expectant mother suddenly felt any malaise (fever, fatigue, nausea, heartburn, etc.), it should remember the following rule: before taking any medicine, you must consult a doctor (even if it considers that the drug is absolutely safe ). It must be remembered that pregnancy has a certain effect on the body due to hormonal changes, and all organs and systems begin to function differently, especially the liver and kidneys. With some "harmless" drug the liver can not cope, and the kidneys remove them from the body.
Especially desirable to take drugs in the first trimester (16 weeks). Because in this period the placenta has not yet formed, and, therefore, not someone to protect the embryo against the harmful effects of drugs. And yet, if it so happened that taking dangerous drugs took place in the first three weeks of pregnancy (21 days), in this case the law of all or nothing. That is, either spontaneously aborted pregnancy or continues to develop without any consequences for the embryo.
Classification of drugs taken during pregnancy
All drugs that are taken during pregnancy can be divided into several groups:
- completely safe products (such as magnesium B6, paracetamol and other);
- drugs do not affect the animals during the study, but not studied their effect on human pregnancy (sumamed);
- drugs have a negative effect on pregnancy, but the benefits they receive exceeds the potential risk (aminophylline);
- absolutely contraindicated medications to take during pregnancy (aminoglycosides, tetracyclines, TB, psychiatric, etc.).
A few words about sumamed
Sumamed is a very strong antibiotic
Antibiotics - whether they will help you in the foreseeable future?
and is appointed in cases of severe or untreatable infections other antibiotics. Sumamed is macrolide antibiotic group (erythromycin) and is the first representative of a new subgroup of macrolide - azalides. The main active agent Sumamed is Azithromycin. This drug has a bactericidal effect, that is, inhibits the growth of bacteria.
Sumamed antibiotics wisely
when: upper respiratory tract infection (sore throat, tonsillitis, sinusitis), scarlet fever
Scarlet fever - threatening complications
, Lower respiratory tract infections (pneumonia, bronchitis), infections of the skin and soft tissues (erysipelas, impetigo), urogenital tract infections.
Sumamed in pregnancy
Sumamed during pregnancy is not indicated (in some cases only in the third trimester). But sometimes there is a necessity of the drug, if the benefits of its use exceeds possible risks. Although there is still action Sumamed during pregnancy remains unexplored. However, it is proved that the drug in animal studies did not have a negative impact. Furthermore, side effects should be considered during reception Sumamed that can be particularly pronounced during pregnancy. These side effects include: nausea, vomiting, diarrhea, rash and allergic reactions.
Rimantadine during pregnancy: impact on the fetus
December 7, 2011
Rimantadine (rimantadine) is not indicated during pregnancy because it can cross the placenta to the fetus and has a number of side effects that can adversely effect both the pregnant woman and the developing fetus. For prevention of influenza in this case it is necessary to use other means, such as interferon.
The mechanism of action of rimantadine
Rimantadine - is an antiviral drug that inhibits the virus replication at an early stage, i.e. at the time of their introduction into the cells of the human body. It operates for 6 - 8 hours, then rapidly degraded in the liver by metabolic products (metabolites). Less than a quarter of the dose is excreted in the urine in unchanged form via the kidneys. It was then, lies the main danger, as the kidneys, and so women are double burden and rimantadine can linger in the blood. Doses higher than normal may have a toxic effect on the body. The body of a pregnant woman is particularly sensitive to any kind of toxic stress. Even a drug that can be applied to most patients in pregnancy are often contraindicated.
Furthermore, the influenza virus is located within the cells of the human body and it is not possible to influence, absolutely without damaging the cells. There is no assurance that the action of rimantadine are damaged cells of vital organs, such as kidneys. And if a healthy person it happens quite easily, the slightest change in the pregnancy status of various organs necessarily affect the status of the fetus.
What is dangerous for pregnant women rimantadine
Clinical trials of the drug in pregnant women and nursing mothers have not been conducted, but animal experiments found that rimantadine crosses the placental barrier and is excreted in breast milk. Rimantadine concentration in breast milk after three hours after a single dose than the concentration in the blood plasma. In the presence of high load on the kidneys, pregnant women and increase plasma concentrations of rimantadine in her blood it becomes really dangerous to the fetus.
Side effects of rimantadine may also adversely affect the pregnancy. For example, the side effects from the digestive organs, like stomach pain
Abdominal pain: Types and Symptoms
, Bloating, abnormal liver function, dry mouth, disturbances of appetite, nausea, vomiting may exacerbate symptoms of early toxemia of pregnancy and disorders of the digestive system that arise during the whole period of pregnancy, such as bloating and constipation.
Side effects in the central nervous system (headache, insomnia, nervousness, dizziness, impaired concentration, drowsiness, anxiety
Anxiety - how to distinguish normal from disease?
, Irritability, fatigue, convulsive readiness) also exacerbate some discomfort during pregnancy. Especially desirable effects of strengthening in the second half of pregnancy, when a woman is threatened toxicosis second half (preeclampsia). Rimantadine in this case, able to stimulate the rise in blood pressure, which is typical for gestosis. And in severe preeclampsia he can provoke increase in cerebrovascular accidents and seizures in pregnant women.
Admission rimantadine official also contraindicated in case of hypersensitivity to the drug, severe liver disease in violation of their functions (due to the increased concentration of drug in the blood of pregnant women, which is unacceptable), under any kidney disease (the same as a high concentration of rimantadine in blood plasma ) at elevated thyroid
The thyroid gland - is responsible for your hormones
(This reinforces the increased excitability and nervousness, and so peculiar how such patients and pregnant women), and children up to one year (the toxic effect of this drug may be harmful for them because of the imperfection of the liver and kidneys).
With caution and only on prescription rimantadine are recommended in the seizure (including epilepsy), stroke and diabetes
Diabetes - threatening and incurable disease
- All these problems are particularly aggravated during pregnancy.
Therefore, to use rimantadine in pregnancy is contraindicated. During the influenza epidemic of influenza disease and pregnant women are much safer to use human interferons, which have no contraindications, as are natural drugs. Better yet, a pregnant woman during a flu epidemic did not attend public places (shops, cinemas), not to go to public transport as far as possible cases of influenza isolated from family members.
Rimantadine - it's a good antiviral drug, but it is contraindicated in pregnant women.