Suprastin - it is anti-allergic drug, which has both advantages and disadvantages. It is able to provide a pronounced antipruritic effect, but significantly depresses the central nervous system. It is used to treat allergic diseases today, but if the patient does not prevent drowsiness and incoordination.

Mechanism of action

Suprastin (active ingredient - Chloropyramine hydrochloride) is an antihistamine of the first generation, which produced the Hungarian pharmaceutical company EGIS in tablets for oral administration (25 mg per tablet) in 1 ml ampoules (1 ml contains 20 mg of the drug). Other pharmaceutical companies Chloropyramine sold under the name subrestin, supramin, Chloropyramine-Verein, Chloropyramine hydrochloride. All of these drugs are analogues suprastin.

Suprastin - a blocker of histamine H1 receptors - nerve endings that are sensitive to histamine - the main substances that contribute to the development of an allergic reaction. That is, this drug, blocking the transmission of histamine interrupt the allergic reactions such as inflammation and edema. If an allergic reaction has started, it makes it easier for suprastin. It has antipruritic effect, relieves swelling and slightly reduces spasm of smooth muscles of blood vessels and internal organs (eg, bronchi). It is used for treatment of allergic diseases and allergic reactions.

After oral tablets suprastina it is rapidly and completely absorbed from the gastrointestinal tract, reaching peak concentration in the first two hours. The therapeutic concentration level is kept for three to six hours. Regardless of the method of exposure Suprastinum well distributed in tissues, passes the blood-brain barrier (i.e., enters the brain tissue). He then decomposed in the liver and excreted through the kidneys and bowels. Children suprastin excreted from the body more quickly than adults.

Indications and contraindications

Indications for use suprastin are:

• urticaria and angioedema (angioedema);
• serum sickness;
• seasonal and perennial allergic rhinitis;
• allergic conjunctivitis;
• hay fever (hay fever) - an allergy to pollen;
• allergic contact dermatitis;
• itching of any origin;
• atopic dermatitis, atopic dermatitis and eczema;
• the initial stages of asthma lung flow (in the complex therapy);
• food and drug allergies;
• allergic reactions to insect stings;
• acute respiratory infections and intestinal infections in children Intestinal infections in children - a serious risk   (in combination with antipyretics).

Contraindications for the purpose suprastin:

• acute attack of asthma;
• Pregnancy and breast-feeding Breastfeeding - a personal choice   breast;
• the neonatal period (the first four weeks of life);
• glaucoma Glaucoma - a perspective possible blindness ;
• prostate adenoma with urinary retention;
• concomitant use of certain sedative drugs (MAO inhibitors);
• stomach ulcer in the acute stage;
• Hypersensitivity to suprastin.

Precautions suprastin appointed in violation of liver and kidney function, in which case the dose is adjusted individually. Be wary appointed suprastin elderly patients and patients who receive any sedatives and sleeping pills. During the course of treatment suprastin can not drink alcohol.

Suprastin can cause impaired motor coordination and psychomotor speed, so when it is received can not engage in potentially hazardous activities, including driving a car.

Side effects and overdose

Suprastin generally well tolerated, but when taking suprastin may experience the following side effects:

• the nervous system - fatigue, lethargy, or nervous excitement, malfunction, dizziness, headache, trembling of the limbs, sometimes with a long reception - elevated mood (euphoria);
• from the gastrointestinal tract - nausea, vomiting, diarrhea or constipation, dry mouth, appetite disorders, pain in the upper abdomen;
• on the part of the cardiovascular system - lowering blood pressure, tachycardia, cardiac arrhythmias;
• from the blood - decrease in the number of white blood cells (leukopenia), reduction or complete disappearance of granular white blood cells (agranulocytosis - causes a reduction of immunity);
• and - difficulty urinating, muscle weakness, increased intraocular pressure, allergic to sunlight.

Overdose suprastin manifested gain any side effects. There are nervous anxiety, confusion, impaired coordination of movements, hallucinations, convulsions, dilated pupils, flushing of the face. If the patient is not provided timely help, there may come a coma followed by death of the patient. First aid: call an ambulance and its arrival to try to wash out the stomach, and then give the patient a few tablets of activated charcoal Activated carbon - old but indispensable . Further treatment occasion in the hospital.

Suprastin - a drug that is taken only on prescription.

Galina Romanenko

Tavegil one of the first drugs that block the action of histamine in the outbreak of an allergic reaction. It relieves allergy such as swelling and itching of the skin, and reduces the exudation - exudation of fluid from the small blood vessels in inflammatory and allergic reactions.

How does tavegil

Tavegil (INN - clemastine) refers to a group of antihistamines - H1-blockers of histamine receptors. This means that prevents access to the site of histamine allergic reaction. And since this is the main manifestation of histamine causes an allergic reaction (swelling, pain, exudation, reduction in blood pressure with anaphylactic shock, and so on), decrease or prevent the symptoms of allergies.

Thus, while suppressing the action of histamine decreases the permeability of small blood vessels, which leads to the removal of edema and exudation (e.g. common cold).

Tavegil has a number of side effects which are not present in modern antihistamines, however, he is now widely used in the treatment of allergic diseases and reactions. The peculiarity of drugs blocker of H1-histamine receptors of the first generation is a rapid onset of action. Tavegil, moreover, also has sufficient duration - 12 hours.

Tavegil available in the following dosage forms:

• in the form of ingestible tablets, 1 mg;
• as a syrup for oral administration (mainly used to treat children and contains 500 mg in 5 ml);
• in a solution for injection in ampoules of 2 ml (1 ml solution containing 1 mg of the drug).

With which diseases and how to take tavegil

Tavegilum prescribed for seasonal allergic diseases, such as hay fever is caused by pollen of various plants. Manifest pollinozy nasal congestion, profuse nasal discharge, eye redness, watery eyes. Unfortunately, the reception Tavegilum difficult to combine with the work, because it causes drowsiness, lethargy and decreased disability. Nevertheless, it is prescribed for certain activities that do not require precise coordination and concentration. Take tavegil exacerbations and year-round allergies - runny nose and conjunctivitis.

It will tavegil as hives - spotted or papular rash, allergic reactions that quickly appears, grows, merges, and quickly disappears. Manifestations of chronic urticaria associated with various physical influences (cold, heat, light) are also reduced by the action Tavegilum.

Assign tavegil as part of comprehensive treatment of all skin diseases which are accompanied by severe itching, including the treatment of a simple contact dermatitis caused by an irritant effect on the skin mechanical and chemical factors.

But it is especially effective for skin diseases of allergic nature - atopic dermatitis (exudative diathesis), atopic dermatitis, eczema. Contact allergic dermatitis, the skin develops from contact with substances that cause allergies, as well to treatment tavegilom.

Bites some insects often cause allergic and inflammatory reactions, such as bee stings - tavegil in this case, remove tissue swelling, itching and pain.

When you can not take tavegil

It does not take tavegil elevated sensitivity to the body, at the age of about one year, and during the feeding of the child Breastfeeding - a personal choice   feeding. Furthermore, it is not co-administered with drugs affecting the central nervous system, especially with antidepressant belonging to the group of drugs - MAO inhibitors.

It should also be aware that it is not necessary to appoint tavegil bronchitis, pneumonia Pneumonia - Symptoms and Causes   and asthma as it increases the viscosity of sputum expectoration and prevents it.

In some cases, the use of Tavegilum has no absolute contraindications, but requires caution. For example, with caution, and only on prescription should be used during pregnancy.

There are other diseases that require careful Tavegilum destination. It glaucoma Glaucoma - a perspective possible blindness , Stenosis (narrowing) of the place of transition of the stomach into the duodenum of any origin, violation of patency of the bladder neck, prostatic enlargement with urine retention, increased thyroid function The thyroid gland - is responsible for your hormones , Severe heart disease, high blood pressure.

Tavegil today, like many years ago, has been successfully used in the treatment of allergic diseases and allergic reactions.

Galina Romanenko