Novinet - side effects: beware of blood clots

Novinet contains synthetic progestin and estrogen components which are more active than the natural sex hormones. The drug prevents the release of FSH and LH hormones that prevent ovulation Ovulation - How to determine as accurately as possible? . The effect is enhanced by increasing the viscosity of the cervical mucus, which hinders the penetration of sperm into the uterus.

A distinguishing feature of the preparation is the minimum content of the estrogen component, which reduces the risk of estrogen-dependent side effects, such as nausea, breast pain, weight gain, thromboembolic complications.

Pharmacokinetics

Ethinyl estradiol and desogestrel is rapidly and almost completely absorbed in the upper small intestine. Both components have a high (90%) of plasma protein binding. The maximum concentration of the components in blood is achieved after 1, 0-1, 5 hours. They are well distributed to organs and tissues, ethinyl estradiol accumulates in adipose tissue. About 10% of the dose enters the breast milk. The half-life averages 24 hours for ethinyl estradiol and about 31 hours for desogestrel. Ethinylestradiol 40% eliminated by the kidneys as metabolites by 60% - the liver.

Indications

Novinet - means of oral contraception, as shown in the functional disorders of the menstrual cycle, dysmenorrhea Dysmenorrhea - the basis of infertility , Premenstrual syndrome.

Use during pregnancy and lactation

Oral contraceptives, which preceded the pregnancy does not increase the risk of various defects in the fetus. Inadvertent use of hormonal contraceptives in the early stages of pregnancy has no teratogenic or mutagenic effects and does not affect the sex of the fetus. The possible risks associated with taking oral contraceptives, in this case far exceeds the benefit; when established pregnancy and suspected it should be abolished steroid hormones. Combined oral contraceptives reduce the release of milk in nursing mothers, so they are not recommended during lactation. A small number of active substances may be excreted in breast milk.

Contraindications

• hypersensitivity to the drug;
• hypertension, moderate or severe;
• hyperlipidemia (familial forms);
• arterial thromboembolic disorders, including history (myocardial infarction, cerebrovascular disease);
• the risk of arterial or venous thromboembolism;
• venous thromboembolism in a personal or family history;
• diabetic angiopathy;
• the presence or indication of a history of severe liver disease, cholestatic jaundice, hepatitis, jaundice during pregnancy syndrome Dubin - Johnson and Rotor, liver cancer, porphyria, medication containing steroids;
• hepatitis Hepatitis - the scourge of our time   (before restoration of laboratory parameters and for 3 months following their normalization);
• cholelithiasis;
• estrogen-dependent tumors (including suspected them), genital bleeding of unknown etiology; systemic lupus erythematosus (including history);
• severe itching, genital herpes, otosclerosis, or deterioration of otosclerosis during a previous pregnancy or steroids;
• migraine;
• pregnancy (including suspected pregnancy);
• sickle cell anemia, chronic hemolytic anemia;
• vaginal bleeding of unknown etiology;
• otosclerosis.

Safety measures

If between taking pills more than 12 chsov, reliability of contraception in the cycle can not be guaranteed. Omitting one tablet on the first or second week of the cycle should take 2 tablets the next day and then regularly. Omitting 2 tablets in a row in first or second week of the cycle - 2 tablets for the next 2 days and then - regular intake of using additional methods of contraception until the end of the cycle; when skipping pills in the third week of the cycle - further ruled seven break. With caution used Novinet heart diseases non-ischemic etiology, hypertension, diabetes, renal dysfunction, epilepsy, chorea Sydenham, bronchial asthma.

Note that oral contraceptives reduced tolerance to carbohydrates and increase the need for insulin or oral antidiabetic agent .  During the reception Novinet require medical supervision at least every 6 months .  After suffering a viral hepatitis application is possible not earlier than 6 months (with normalization of liver function) .  In the case of vomiting or diarrhea you must use additional mechanical contraceptive method .  During the reception should give up smoking (increases the frequency of thromboembolism various sites, especially in women older than 35 years) .  Admission should be discontinued 3 months before the planned pregnancy for 4 weeks before planned surgery and during prolonged immobilization (eg after injuries), as well as immediately upon creation or strengthening of migraine or unusually severe headache, sudden loss of vision, suspected thrombosis or cerebral infarction, sudden increase in blood pressure, jaundice or hepatitis without jaundice, generalized itching, or shortness of occurrence of epileptic seizures .

Interaction with Drug

Novinet compatible with other pharmacological agents, but before taking the drug should consult a doctor and inform about all medicines Phytopreparations nutritional supplements that you are taking, including non-prescription.

Novinet should not be used in conjunction with:

• inducers of hepatic microsomal oxidation, such as rifampicin derivatives, phenobarbital, anticonvulsants (phenytoin, carbamazepine), dihydroergotamine, some tranquilizers, phenylbutazone, ketoconazole as well as broad spectrum antibiotic (tetracycline, chloramphenicol, ampicillin, neomycin) because of the high reduce the risk of contraceptive effect Novinet.

Novinet should be used with caution in combination with:

• anticoagulants - coumarin derivatives or indandiona (you may need to monitor the prothrombin time and change the dose of anticoagulant);
• tricyclic antidepressants, maprotiline; beta-blockers (can increase the bioavailability and therefore the toxicity of these drugs);
• oral antidiabetic drugs, insulin (may need to change their dose);
• bromocriptine (decrease effectiveness);
• hepatotoxic drugs, primarily dantrolenom (risk of increased hepatotoxicity, especially in women older than 35 years).

Dosage

Oral administration of the drug, it is desirable to start the day of occurrence of menstruation (ie, the first day of the menstrual cycle). Duration - 21 days. The daily dose Novinet - 1 tablet. The tablets should preferably be taken at certain times. After the use of the contents of the package (21 tablets) is a seven-day break. During this period there menstrualnopodobnoe bleeding due to the termination of Novinet. After the break the drug scheme resumes. Capable of receiving the first pill from the first and from the second to fifth day of the menstrual cycle The days of the menstrual cycle: Four phases . In such a case, you should use additional methods of contraception during the first seven days of use of the drug. Start receiving Novinet after five days from the onset of menstruation is not advisable. After delivery drug is given after 21 days (after the abortion - after 1 day). In the case took place during this period, initiation of sexual contact is delayed until menstruation.

Storage conditions

Novinet Store in a dry, dark place at a temperature of 15-30 ° C. Shelf life - 3 years.

Side effects

Like all hormonal contraceptives Novinet effectively prevent pregnancy, but in some cases can cause individual reactions. Carefully read the instructions to the drug, exactly follow all the regulations and instructions of the doctor.

Side effects of the nervous system and sensory organs:

• headache;
• migraine;
• mood changes;
• depression;
• hearing loss;
• Sydenham's chorea (in this case the drug should immediately stop).

Side effects of the drug on the part of the cardiovascular system and blood:

• increased risk of arterial and venous thromboembolic diseases such as myocardial infarction, stroke, deep vein thrombosis of the lower extremities, pulmonary embolism);
• hypertension.

Side effects of the drug from the gastrointestinal tract:

• nausea (most common in young girls and women with low weight to eliminate this symptom is sometimes enough to make Novinet of food);
• vomiting;
• ulcerative colitis;
• cholelithiasis;
• cholestatic jaundice.

Side effects of the drug on the part of the genitourinary system:

• intermenstrual bleeding (usually disappear within five to six menstrual cycles);
• amenorrhea (5% of cases, after stopping the menstrual cycle is fully restored in six months);
• changes in vaginal mucus;
• candidiasis.

Side effects of the drug with the skin:

• nodular erythema;
• rash;
• chloasma;
• Allergic reactions: seldom - reactive exacerbation of systemic lupus erythematosus.

Other side effects of the drug:

• tension;
• pain;
• hair loss;
• and an increase in the allocation of milk from the breasts;
• increased sensitivity of mammary glands;
• improving corneal sensitivity while wearing contact lenses;
• fluid retention;
• decreased libido;
• changes in body weight;
• reduced tolerance to carbohydrates.

While birth control pills Novinet require medical supervision at least every 6 months. After suffering a viral hepatitis Novinet application may not be earlier than 6 months (with normalization of liver function). In the case of vomiting or diarrhea you must use additional mechanical contraceptive method. While birth control pills Novinet should stop smoking, since smoking increases the risk of venous thromboembolism various sites, especially in women older than 35 years.