The pain associated with spasms of smooth muscles of internal organs, occur frequently and are not always a sign of serious illness. They can cause eating disorders (spasms of the stomach, intestines and bile ducts), stress (may cause spasms anywhere in the body), high physical and emotional stress, and so on. Papaverine in this case it is easy to cope with the pain.

How does papaverine

Papaverine belongs to the group of drugs, relieves spasms of smooth muscles of internal organs and blood vessels by acting directly on muscle fibers (myotropic antispasmodics).

When administered into the rectum, and the intramuscular or intravenous papaverine quickly enters the bloodstream and is distributed in the tissues and has a therapeutic effect. When administered papaverine is not fully absorbed and works more slowly, so papaverine pill less effective than other dosage forms.

Once in the muscle tissue, papaverine inhibits the action of an enzyme that breaks down a substance inhibiting the formation of actomyosin - specific protein by means of which the movement in the muscle fibers. The absence of an effect of removing actomyosin spasm of smooth muscles of internal organs and blood vessel walls.

This leads to improved blood circulation body, relieve pain associated with cramps, bronchial dilation and removal of bronchospasm, some reduction in blood pressure.

Papaverine used to treat patients for many years, it has established itself as an effective and safe means enough. Adverse effects with therapeutic doses it gives a little, almost all the side effects associated with high doses or drugs, or ignoring contraindications to its use.

Despite the fact that the safety of papaverine during pregnancy are not scientifically proven, it continues to apply in hypertonicity of the uterus - a spasm of smooth muscles of the uterus, which can lead to miscarriage Miscarriage - why you lose the most precious thing? .

When and how to apply

Papaverine is widely used to relieve spasms and associated pain of the gastrointestinal tract. Papaverine well with painkillers, removing the pain arising from spasm of the stomach and intestines.

Very good papaverine relieves spasms biliary and urinary tract, so it is often prescribed for attacks of hepatic or renal colic. Often papaverine indicated for stagnation of bile in the biliary tract associated with spasm of smooth muscles (biliary dyskinesia of hyperkinetic type).

In bronchial asthma papaverine administration may withdraw an attack of bronchospasm and bronchitis Bronchitis - protection if the body has malfunctioned   improve expectoration. Therefore, papaverine often prescribed for infectious and inflammatory and allergic diseases of the respiratory system.

On the smooth muscles of blood vessel walls papaverine operates less effectively, however, it is somewhat relieves spasms of the coronary arteries at an attack of angina Angina - oxygen deficiency   and cerebral arteries during cerebrovascular disorders. May drop slightly and blood pressure. The use of papaverine as a course of treatment will reduce the spasm of peripheral arteries, for example, endarteritis obliterans.

Since papaverine well with painkillers, it is often used for sedation - preparation for surgery under general anesthesia.

Finally, papaverine can be used to remove the "random" pain - spasms of smooth muscles of the gastrointestinal tract caused by errors in diet, stress, high physical and psychological stresses and so on. Use in this case better than papaverine in rectal suppositories - so it is faster and more efficient.

Side effects and contraindications

When receiving papaverine can have side effects such as nausea, constipation, increased sweating, lethargy, drowsiness, blood pressure reduction. Occasionally may cause transient liver dysfunction in the form of increase in the blood levels of liver enzymes.

When using high doses of papaverine, as well as its rapid intravenous administration may develop heart block and cardiac arrhythmias.

Papaverine is contraindicated if you are hypersensitive its components the body of the patient, heart block, liver dysfunction in the elderly and in the first six months of life.

The caution is recommended papaverine in violation of the kidneys and adrenal glands, after head injuries, hypothyroidism (decreased thyroid function), hyperplasia Hyperplasia - do not be afraid   (swelling) of the prostate and shock. During the course of treatment can not be used alcohol.

Galina Romanenko

Papaverine - a drug that was introduced in medical practice for many years. After that were issued more effective drugs of this series. Nevertheless, papaverine almost as widely used in the treatment of various diseases, as before.

Why papaverine popular for so long

Papaverine is a "long-lived" - it is often prescribed to treat a variety of diseases. Apply papaverine as part of complex treatment, and independently, for emergency relief of painful spasms of smooth muscles of internal organs.

Available papaverine in three dosage forms - in the form of tablets for oral, rectal suppositories and 2% solution for injection. Tablets papaverine are not too successful dosage form, as not completely and sufficiently slowly absorbed in the gastrointestinal tract, therefore they are used less frequently.

Rectal suppositories, by contrast, are fast and effective - it allows you to use them as a part of complex treatment and as monotherapy for the removal of the lungs and severe painful spasms of smooth muscle.

For emergency use convenient dosage form as a solution for intramuscular and intravenous injections. With the solution, you can snimatdazhe severe cramps: intravenous injection of papaverine even able to stop an attack of acute pancreatitis.

Papaverine well with pain medication, so it is often a part of the complex preparations with antispasmodic and analgesic. These drugs are omnopon, andipal Andipal - if not the strength to bear the pain , Papazol and others.

Equally important is the price of the drugs, it is several times lower than Cna product of the same series - shpy.

The use of papaverine for the treatment of diseases of the gastrointestinal tract

Chronic diseases of the stomach and intestines often accompanied by painful spasms of smooth muscles of these organs. Furthermore, such spasms can cause severe pain, they are dangerous and those that compress small blood vessels in the walls of the gastrointestinal tract. This leads to a deterioration of food in the stomach wall or the intestines and the progression of chronic diseases.

Especially dangerous is poor circulation in the walls of the gastrointestinal tract in the ulcerous processes erosive gastritis, gastric ulcer and duodenal ulcers, ulcerative colitis. Malnutrition causes necrosis (death of) the different cell layers of the walls of the gastrointestinal tract, and this leads to the spread and deepening ulcer process.

If you do not remove the spasm of smooth muscles, the ulcerative process is complicated internal bleeding (in the destruction of the wall of a more or less large vessel) or perforation (breach of integrity) and hit the wall of the contents of the gastrointestinal tract into the sterile abdominal cavity. It always ends with heavy-infectious inflammatory process - peritonitis.

Papaverine may be applied in such diseases as a treatment (permanent spasmolysis) and a single application (for the treatment of severe pain).

The use of papaverine in hepatic and renal colic

Hepatic and renal colic - a condition that has a lot in common. They develop on the background of stone or gallstone disease and are associated with the passage of bile or urinary tract stones. Suffice it compresses a large stone wall duct, causing it ischemia Ischemia - when the brain fails to work   (sharp infringement of blood circulation), and severe pain.

Remove this attack can only be by means of antispasmodics, which are often prescribed along with analgesics. Mild attacks of hepatic or renal colic Renal colic: a signal that the danger in the bud   can be removed using rectal suppositories with papaverine Papaverine - for pain caused by spasms of smooth muscles . Severe attacks are taken as intramuscular or intravenous administration of the drug. Intravenous injection of papaverine is very effective, but it must not be forgotten that papaverine in this case should be diluted with saline and that this solution should be administered slowly, otherwise you may experience side effects from the heart.

The use of papaverine in other diseases and conditions

Papaverine is widely used in obstetrics and gynecology, urology - many chronic infectious and inflammatory diseases cause spasm of blood vessels and eating disorders of an organ, as it slows down the recovery.

Respiratory diseases papaverine enhances bronchial removal of bronchospasm and better sputum discharge.

Papaverine used in all diseases of internal organs, which are accompanied by smooth muscle spasms.

Galina Romanenko