The pain associated with spasms of smooth muscles of internal organs, occur frequently and are not always a sign of serious illness. They can cause eating disorders (spasms of the stomach, intestines and bile ducts), stress (may cause spasms anywhere in the body), high physical and emotional stress, and so on. Papaverine in this case it is easy to cope with the pain.
How does papaverine
Papaverine belongs to the group of drugs, relieves spasms of smooth muscles of internal organs and blood vessels by acting directly on muscle fibers (myotropic antispasmodics).
When administered into the rectum, and the intramuscular or intravenous papaverine quickly enters the bloodstream and is distributed in the tissues and has a therapeutic effect. When administered papaverine is not fully absorbed and works more slowly, so papaverine pill less effective than other dosage forms.
Once in the muscle tissue, papaverine inhibits the action of an enzyme that breaks down a substance inhibiting the formation of actomyosin - specific protein by means of which the movement in the muscle fibers. The absence of an effect of removing actomyosin spasm of smooth muscles of internal organs and blood vessel walls.
This leads to improved blood circulation body, relieve pain associated with cramps, bronchial dilation and removal of bronchospasm, some reduction in blood pressure.
Papaverine used to treat patients for many years, it has established itself as an effective and safe means enough. Adverse effects with therapeutic doses it gives a little, almost all the side effects associated with high doses or drugs, or ignoring contraindications to its use.
Despite the fact that the safety of papaverine during pregnancy are not scientifically proven, it continues to apply in hypertonicity of the uterus - a spasm of smooth muscles of the uterus, which can lead to miscarriage
Miscarriage - why you lose the most precious thing?
When and how to apply
Papaverine is widely used to relieve spasms and associated pain of the gastrointestinal tract. Papaverine well with painkillers, removing the pain arising from spasm of the stomach and intestines.
Very good papaverine relieves spasms biliary and urinary tract, so it is often prescribed for attacks of hepatic or renal colic. Often papaverine indicated for stagnation of bile in the biliary tract associated with spasm of smooth muscles (biliary dyskinesia of hyperkinetic type).
In bronchial asthma papaverine administration may withdraw an attack of bronchospasm and bronchitis
Bronchitis - protection if the body has malfunctioned
improve expectoration. Therefore, papaverine often prescribed for infectious and inflammatory and allergic diseases of the respiratory system.
On the smooth muscles of blood vessel walls papaverine operates less effectively, however, it is somewhat relieves spasms of the coronary arteries at an attack of angina
Angina - oxygen deficiency
and cerebral arteries during cerebrovascular disorders. May drop slightly and blood pressure. The use of papaverine as a course of treatment will reduce the spasm of peripheral arteries, for example, endarteritis obliterans.
Since papaverine well with painkillers, it is often used for sedation - preparation for surgery under general anesthesia.
Finally, papaverine can be used to remove the "random" pain - spasms of smooth muscles of the gastrointestinal tract caused by errors in diet, stress, high physical and psychological stresses and so on. Use in this case better than papaverine in rectal suppositories - so it is faster and more efficient.
Side effects and contraindications
When receiving papaverine can have side effects such as nausea, constipation, increased sweating, lethargy, drowsiness, blood pressure reduction. Occasionally may cause transient liver dysfunction in the form of increase in the blood levels of liver enzymes.
When using high doses of papaverine, as well as its rapid intravenous administration may develop heart block and cardiac arrhythmias.
Papaverine is contraindicated if you are hypersensitive its components the body of the patient, heart block, liver dysfunction in the elderly and in the first six months of life.
The caution is recommended papaverine in violation of the kidneys and adrenal glands, after head injuries, hypothyroidism (decreased thyroid function), hyperplasia
Hyperplasia - do not be afraid
(swelling) of the prostate and shock. During the course of treatment can not be used alcohol.