Pariet - instructions for a drug that clearly shows all the indications and contraindications for its use. Pariet is used in diseases of the digestive system, associated with increased secretion of gastric juice. At the same therapeutic efficacy increases during continuous use.

The mechanism of action Pariet

Pariet (active substance - rabeprazole sodium) - a drug with anti-ulcer action, a proton pump inhibitor, the manufacturer - an international pharmaceutical concern Janssen. The drug is available in tablets for oral administration, enteric-coated. Each tablet contains 10 or 20 mg of active principle and adjuvants - mannitol, magnesium oxide, magnesium stearate, low substituted hydroxypropylcellulose, ethylcellulose, hypromellose phthalate, monoglyceride diacetylated, talc, titanium dioxide, red iron oxide, ethanol (evaporates during manufacture ), Purified Water (evaporates during production), carnauba wax, gray edible food gray ink, 1-butanol (evaporates during manufacture).

Pariet mechanism of action is related to the suppression of the enzyme of the hydrogen-potassium adenosine triphosphatase (H + / K + -ATPase) in the gastric parietal cells, which leads to blocking of the final stage of the formation of hydrochloric acid. Pariet converted to the active form in the intracellular canaliculi of the parietal cell, where the suppression action H + -K + -ATPase. The result is a decrease in the secretion of hydrochloric acid until its complete cessation.

In addition, Pariet, having a high lipophilicity (prone to fat tissue), easily penetrates the parietal cells of the stomach, is concentrated in them and has cytoprotective (protecting cells) action. The action comes fast and Pariet depends on the size of the dose and duration of use. Ingestion Pariet 20 mg tablet an hour causes a decrease in gastric acid secretion. The maximum therapeutic effect is achieved after about three hours and kept for 48 hours. The therapeutic effect of the drug with regular admission increases and becomes stable after three days. Once the drug is stopped, the secretion of gastric juice is recovered within three days.

Pariet may also suppress the vital activity of Helicobacter pylori - the infectious agent of bacterial origin, which is a common cause of stomach ulcers and duodenal ulcers.

Indications and contraindications for the use of Pariet

Indications for use Pariet Pariet: how to cope with gastric ulcer and duodenal ulcer   are diseases of the digestive system, accompanied by high acidity of gastric juice:

• duodenal ulcer in the acute phase, including those caused by Helicobacter pylori;
• gastroesophageal reflux disease (GERD) - a disease associated with irritation of the esophagus from the stomach throw-acidic gastric juice;
• Zollinger-Ellison syndrome - a benign tumor of the pancreas that produces gastrin, which stimulates the secretion of gastric juice, causing ulcerative lesions of the stomach and duodenum;
• ulcerative lesions of the stomach from chronic administration of nonsteroidal anti-inflammatory drugs;
• as part of a treatment with antibiotics in detecting gastric contents in patients with gastric ulcer or chronic gastritis, Helicobacter pylori.

Pariet is contraindicated reception during pregnancy, infant feeding Breastfeeding - a personal choice   breast in childhood and hypersensitivity to its components or drugs of the same group of the patient.

Side effects

In most cases pariet well tolerated, but there are side effects:

• from the gastrointestinal tract - dry mouth, diarrhea or constipation, abdominal pain Abdominal pain: Types and Symptoms , Flatulence, nausea, vomiting, loss of appetite;
• of the liver - transient disturbances of the liver in the form of changes in laboratory parameters;
• the central nervous system - headache, malaise, weakness, drowsiness or insomnia, dizziness;
• From hemopoiesis system: seldom - a reduction of blood platelets and leukocytes, that long-term use Pariet can lead to decreased immunity and increased bleeding;
• may occur as back pain, joint and muscle pain, weight gain, depression Depression - a little more than a bad mood , Blurred vision and taste, stomatitis, increased sweating, and allergic reactions.

Pariet - it is an effective anti-ulcer drug, which is generally well tolerated and rarely has significant side effects.

Galina Romanenko

A Normoflorin actively restores intestinal microflora, particularly in children under one year and enhances immunity Strengthening the immune system - help the immune system . Children after a course of the drug get sick less often and less seriously reduced the number of colds, recurrence of infectious and inflammatory and allergic diseases.

Normoflorin A - Bad overall health

Normoflorin A - is a biologically active food additive, which consists of lactobacilli in an amount not less than 10 ^ 10 CFU / mL (CFU - koloneobrazuyuschaya this unit, which is up to 240 bacterial cells). Produced Normoflorin A domestic pharmaceutical company Bifilyuks as a liquid concentrate in flakonah- 20 mL (up to years), as well as conventional bottles of 50 or 100 ml.

All Normoflorin (they produced three species) are symbiotic - drugs that contain not only useful for intestinal bacteria (probiotics), and substances necessary for their "feeding" that they did not die after being hit in the gut, but settled down and active bred (prebiotics). The structure includes normodipin A metabolic products lactic acid bacteria (amino acids, organic acids, vitamins, micro and macro) and prebiotic lactitol, which enhances the process of life of colonies of lactic acid bacteria.

Under the influence of Normoflorin A reduced amount of conditionally pathogenic and pathogenic intestinal microflora and output formed during their metabolic toxins, restore normal motor activity of the intestine. Because the body is also displayed excess cholesterol, which contributes to the formation of cholesterol plaques in blood vessels. Derivation of certain salts (eg, salts of oxalic acid - oxalate), which are capable of forming stones in the biliary and urinary tracts.

A Normoflorin activates the formation of a protective immunoglobulin A, which is in the mucous membranes of the body and protects against the penetration of pathogenic bacteria. Restoration of the gastrointestinal tract contributes to the overall improvement of metabolism Metabolism: The basis of life of all living things Including the absorption of the cells of nutrients and oxygen - it reinforces cell resistance to any external influences.

We heal the digestive organs

Normoflorin A particularly recommended premature babies - it actively prevents the growth of harmful microflora, resulting in the child actively sucks the breast, putting on weight and growing.

In preschool and primary school age under the influence of malnutrition and high nervous and mental stress begin to form chronic gastrointestinal disease. If at this moment is not to try to prevent this process, it is formed in this period, the disease will accompany human life. A reception Normoflorin courses will restore the proper functioning of the gastrointestinal tract and prevent the development of chronic diseases.

Not less frequently at this age are developing the disease biliary tract and gall bladder Gall bladder: structure and function . This contributes to a relatively sedentary lifestyle and student information and great emotional stress at school. This reduces the motor activity of muscles of biliary tract and the bile starts to stagnate. Over time in the biliary tract stones can be formed on the basis of some kinds of salts. Remediation of the gastrointestinal tract results in increased locomotor activity in the biliary tract, wherein the body is actively excreted salts such as oxalates.

What other agencies can improve by taking Normoflorin A

Oxalates may be postponed and in the urinary tract, of which here can be formed rocks and stones in the urinary tract is almost always cause inflammation. Thus, reception Normoflorin Normoflorin - used to prevent   A is the prevention of various diseases and kidney.

A reception Normoflorin help improve and nasopharynx, because work properly gut produce more immune cells that protect the body from infections. And in the mucous membranes of a large number of immunoglobulin A, which does not allow the ingestion of infection.

Admission Normoflorin A is recommended in allergic processes in the lungs and airways. Removing toxins from the gut - this is a warning exacerbation of allergic diseases, because very often it is the emergence of new toxins provoke skin rash or asthma attacks.

With the purpose of improvement Normoflorin A can be taken alone, in accordance with the instructions attached to it.

Galina Romanenko