In the treatment of endometriosis - a disease in which cells of endometrium throughout the body, take root in various organs and begin to function, subject to cyclical changes in the menstrual cycle and its phases typically use hormones. Utrozhestan is a hormonal agent, and is widely used in gynecological and obstetric practice. But Utrozhestan in endometriosis as a treatment of this disease is not assigned. The drug can be used only for the prevention of endometriosis, or to maintain the pregnancy occurred on the background of the disease.

Separately on progesterone

Progesterone (hormone yellow body) refers to the female sex hormone, and is produced by the ovaries. The level of progesterone increases in the second (luteal) phase of the menstrual cycle. Progesterone provides secretory changes in the endometrium, thereby preparing the uterine lining for the introduction (implantation) of a fertilized egg and its further growth and development. Since the sixteenth week of pregnancy, progesterone Progesterone - norm and pathology   It begins to be synthesized by the placenta. It is the content of progesterone in the second phase of the menstrual cycle depends on the possibility of a woman becoming pregnant and during pregnancy, the hormone ensures the development of the ovum and prevents miscarriage and premature birth.

The causes of endometriosis include hormonal failure in the body, against which develops a relative or absolute hyperestrogenia (ie there is a lack of progesterone, which reduces the likelihood of a woman becoming pregnant, and in the case of conception bear a child).

The mechanism of action utrozhestan

Utrozhestan is an analogue of progesterone and is made from herbal ingredients. Produced Utrozhestan capsules of 100 mg and can be used intravaginally (introduction into the vagina), and orally.

Active ingredient of the drug - Progesterone stimulates the formation of normal secretory endometrium during the second phase of the menstrual cycle, ie contributes to cyclical changes in the endometrium. Due Utrozhestanu, proceed endometrium from a proliferative into a secretory phase, and the incident after conception provides optimal conditions for the implanted egg. In addition, Utrozhestan decreases contractility and excitability of the muscle layer of the uterus and fallopian tubes Fallopian tubes: an important part of the reproductive system And participates in the development of mammary glands and preparing them for lactation.

Indications for utrozhestan endometriosis

As already noted, Utrozhestan may be imposed only for the prevention of pregnancy, or endometriosis, which emerged on the background of the disease. Indications for use of the drug as follows:

• infertility due to endometriosis associated with luteal insufficiency;
• menstrual disorders, which lead to the development of anovulation Anovulation - the cause of infertility?   (eg, endometrioid ovarian cyst);
• progesterone deficiency in the "idle" the ovaries;
• maintenance of the second phase of the menstrual cycle as a preparatory treatment for in vitro fertilization (often endometriosis patients have to resort to this method of treatment of infertility);
• prevention of threatened or begun miscarriage endometriosis;
• prevention of endometriosis (the presence of relative or absolute hyperestrogenism);
• in some cases, for the treatment of adenomyosis Adenomyosis - treatment should be individualized   uterus (Utrozhestan only effective in 40% of cases).

Contraindications

Despite all these advantages, the drug has a number of contraindications to the appointment. These include:

• tendency to thrombosis (blood clotting increased);
• acute phlebitis or thrombophlebitis;
• bleeding from the genital tract neutonchennogo origin;
• malignant neoplasms of the mammary glands and organs of the reproductive system or suspicion of their presence;
• expressed human liver (liver failure).

Anna Sozinova

Utrozhestan - a drug, an active substance which is the female sex hormone progesterone. A feature of the preparation is that it is available in capsule, whereas progesterone traditionally only available in the form of an oily solution for injection.

The mechanism of action utrogestan

Utrozhestan (active substance - progesterone) produced a group of pharmaceutical companies Bezen Helska capsules of 100 mg and 200 mg. The capsules can be taken both inside and inserted into the vagina instead of candles.

Part of the progesterone utrogestan Progesterone - norm and pathology   It is a natural micronized drug, which is well absorbed in the gastrointestinal tract and the vagina. When taken into capsules within one to three hours in the blood is sufficient therapeutic concentration of progesterone effect of the drug is maintained for at least eight hours. At introduction into the vagina capsules absorption into the bloodstream with achieving maximum concentration occurs within two to six hours, when administered twice daily it operates 24 hours.

Progesterone is produced in the corpus luteum of the ovary (in place of the ruptured follicle, which comes from the egg) in the second half of the menstrual cycle after ovulation. In the first half of the menstrual cycle were the main hormones estrogen under the influence of the mucous membrane of the uterus thickens, preparing to accept a fertilized egg. In the second half of the cycle produces the hormone progesterone, which is under the influence of the mucous membrane of the uterus stops increasing in volume and starts to produce the secret necessary for development of pregnancy.

If pregnancy occurs, progesterone helps the uterus in a state of transition, necessary for development of the fertilized egg. At the same time he was actively inhibits motor activity of muscles of the uterus, thereby wearing out pregnancy. At the same time, progesterone prepares the mammary glands to function by stimulating the growth of terminal elements ducts of the breast and lactation.

Under the influence of progesterone metabolism changes Improves metabolism and losing weight without dieting , An organism accumulates the nutrients that are needed for it to continue pregnancy. It's fat reserves, which are deposited in the thighs and abdomen, protecting the fetus from injury, glycogen (the substance from which, if necessary, can be easily obtained glucose - the energy necessary material), insulin (it promotes the absorption of glucose into cells). Progesterone also reduces the content of nitrogen in the blood of toxic metabolic products, increases the excretion of nitrogen in urine.

Indications for use

Indications for use utrogestan are diseases and conditions caused by lack of progesterone in a woman's body. Admission into capsules utrogestan appointed:

• infertility caused by lack of progesterone;
• premenstrual syndrome caused by an excess of estrogen and progesterone disadvantage;
• anovultornom during the menstrual cycle (it is not accompanied by the release of an egg from the ovary, or ovulation);
• when mastitis - hormonal disorders of breast work associated with high concentration of estrogen in the blood, contributing to the widening of breast tissue; Progesterone inhibits the growth of tissue;
• under condition before menepauzoy and menopause - as a replacement therapy with estrogen.

Introduction utrogestan capsules into the vagina (vaginally) to designate:

• as replacement therapy with a lack of progesterone, for example, if a woman spayed at early menopause;
• to support the luteal phase of the menstrual cycle (second half of the cycle) in preparation for in vitro fertilization;
• infertility, develop on the background of lack of progesterone;
• to support the luteal phase of the menstrual cycle when progesterone deficiency in spontaneous (natural) or induced (eg, in patients receiving hormonal contraceptives) menstrual cycle;
• during pregnancy to suppress the contractility of the muscles of the uterus and prevent miscarriage;
• for preventing hormonal diseases caused by elevated blood levels of estrogen - endometriosis and uterine fibroids.

Contraindications

Admission utrogestan contraindicated in increased blood clotting (it promotes the formation of blood clots), bleeding of unknown origin from the genital tract, incomplete abortion (when the fetus to save can not be), porphyria (metabolic disorders that manifest photophobia), hormone-dependent tumors of the breast and female genital organs , severe liver disease in violation of its functions, hypersensitive to the components of the drug.

Precautions utrozhestan Utrozhestan - corrects the deficiency of progesterone   prescribed for cardiovascular disease, severe kidney disease in violation of their function, diabetes, asthma, epilepsy, migraine, depression, disorders of lipid metabolism, in feeding the baby Breastfeeding - a personal choice   feeding.

Side effects utrogestan appears when taking it into a lethargy, drowsiness, dizziness (this prevents the occupation of potentially hazardous activities), reducing the length of the menstrual cycle, intermenstrual bleeding, jaundice on the background of stagnation of bile, itching, allergic reactions.

Galina Romanenko