Ascorutin - a drug, the effectiveness of which is verified by decades. It operates slowly enough, however, the effect is always positive, and it passes immediately after the end of treatment. It is used both for treatment and prevention of changes in the small blood vessels - capillaries.

How does Ascorutinum

Ascorutin - a drug whose active substance is ascorbic acid (vitamin C) and rutin (vitamin P). This two vitamins that have a significant positive effect on the blood vessel walls (angioprotective action). They reduce the inflammation in the vascular wall and reduce swelling. As a result, the blood vessels become denser and less permeable to the liquid portion of blood. Angioprotective effect is particularly pronounced in relation to the small blood vessels - capillaries.

Another important property Ascorutinum - the ability to inhibit the toxic effects of free radicals, which are formed as a result of metabolism Metabolism: The basis of life of all living things   in the body and cause death or rapid aging of cells (antioxidant effect). A special feature is ideal Ascorutinum compatibility of vitamins C and P, the latter helps to transport ascorbic acid to tissues.

Ascorbic acid - is the active component of the oxidation-reduction reactions, it is also involved in carbohydrate, fat and protein metabolism in the formation of steroid hormones, connective tissue. Ascorbic acid has angioprotective properties, strengthens the immune system - the body's ability to resist various influences, including infectious agents. By optimizing the metabolic processes in cells, ascorbic acid reduces their need for vitamins B, A, E. A very useful property of ascorbic acid is its ability to enhance the absorption of iron fabrics, and therefore try to iron drugs administered together with ascorbic acid.

Rutin - bioflavonoid derived from some plants, for example, from rue. It is an active angioprotector, which is prepared on the basis of a known drug with angioprotective properties as troksevazin Troxevasin - will help if there are problems with veins . This routine reduces inflammation and swelling in the walls of blood vessels and prevents the formation of blood clots. It activates the blood circulation in the capillaries and is an excellent prevention of thromboembolism. When taken together with ascorbic acid delivers it directly into the tissue cells without increasing the power consumption.

Who and how to take

Ascorutin available in tablets and refers to the non-prescription drugs, but to make it all better if indicated and prescribed by a doctor - it is more efficient.

The main indication for receiving Ascorutinum is a deficiency of vitamins C and E in the body (hypovitaminosis C and P).

Almost always Ascorutinum part of the complex treatment of hemorrhagic diathesis - diseases in which impaired permeability of blood vessels and blood clotting. This is manifested in the form of increased bleeding and the appearance of the skin of small, medium and large bleeding (hemorrhage).

Changes in the walls of blood vessels and capillaries is especially characteristic for a number of other diseases. For example, radiation sickness (it can develop after radiation therapy of cancer), infectious and allergic diseases (rheumatic fever, glomerulonephritis), infectious diseases (influenza, typhus, measles Measles in children - may cause serious complications , Scarlet fever), hypertension and so on. Ascorutin designated as part of an integrated treatment of these serious diseases, capable of gradually improve the condition of blood vessels and alleviate the condition of patients.

Sometimes Ascorutinum prescribed prophylactically with drugs, could adversely affect the capillary walls and significantly reduce rolling capacity of the blood (eg, aspirin and anticoagulants).

Take Ascorutinum after meals with water. The dose of the drug is assigned a doctor and depends on the application. For example, for the prevention Ascorutinum designate one or two tablets a day, and for the treatment - the same dose of two to three times per day. The duration of treatment as determined by a physician, but the average is three - four weeks.

Do Ascorutinum contraindications and side effects?

The main contraindication to receiving Ascorutinum is an idiosyncrasy of its components. Do not take it in the first 12 weeks of pregnancy - it is dangerous to the fetus, as well as children up to three years. In addition, it can not be applied at an elevated blood clotting and a tendency to thrombosis, diabetes Diabetes - threatening and incurable disease , Gout.

Side effects are rare, mainly in long-term uncontrolled taking the drug - it is high blood pressure, insomnia, formation of stones (oxalate) in the urinary tract. For short courses may cause nausea, vomiting, headaches, flares.

Galina Romanenko

Curantil - a phosphodiesterase inhibitor, increases adenosine in plasma and having a vasodilator and antiplatelet properties.

Pharmacological properties

Curantil is a competitive inhibitor of adenosine deaminase - an enzyme that breaks down adenosine, thereby increasing myocardial concentrations of adenosine participating in coronary blood flow autoregulation .  Curantil dilates coronary vessels, increases coronary blood flow volume rate, improves the myocardial oxygen supply, improves its resistance to hypoxia .  The drug inhibits platelet aggregation and prevents thrombosis .  This effect is probably due to the stimulation of the synthesis of prostacyclin and inhibition of the biosynthesis of thromboxanes .  Curantil improves blood circulation in collateral vessels for violations thereof in the major coronary arteries .  Decreases total peripheral vascular resistance, significantly reduces systemic arterial pressure, improves cerebral blood circulation; contributes to the improvement of renal function at giomerunonefrite .

Description of the therapeutic properties of the drug

Curantil sometimes called anticoagulant since it prevents the formation of thrombi. The drug dilates blood vessels of the heart and increases the amount and speed of blood flow, improve myocardial oxygen supply. This increases the stability of the heart muscle to lack of oxygen.

Indications curantyl

The main indications for use curantyl are various types of angina, especially angina Angina - the consequences of the activity Arising under emotional and physical stress, cerebrovascular accident, encephalopathy and placental insufficiency in pregnancy complications. Curantil indicated for the prevention of postoperative thrombosis and myocardial infarction and thrombosis Thrombosis - the cause of heart attack and stroke   cerebral vessels. Used Courant and in pediatric practice.

Mode of application

Curantil taken orally as tablets or pills. When taken orally drug is rapidly absorbed from the gastrointestinal tract. Is drug inside an empty stomach one hour before a meal, usually three times a day. Intramuscular and intravenous drug administered is very rare because of the numerous side effects. Curantil not be injected under the skin, as this manifests his irritating. The drug can not be combined in the same syringe with other drugs as possible precipitation. The course of treatment and the dose prescribed by the doctor.

Side effects curantyl

When receiving curantyl in some cases, side effects are the following:

• lowering blood pressure;
• nausea;
• noise in the head and vertigo;
• nose bleed;
• increased sensitivity of the gums;
• headache;
• heart pain Pain in the heart - always consult a doctor   (rarely);
• short-term reddening of the face;
• dyspepsia;
• pain in the liver;
• darkening of the urine or stool.
• itching.

When one or more of these symptoms should immediately seek medical attention.

Contraindications

Curantil contraindicated in advanced atherosclerotic heart disease, atherosclerosis, coronary artery disease, acute myocardial infarction, heart failure, arrhythmias, hypotension, renal failure Kidney failure - when treatment is vital   and during pregnancy. It is also contraindicated in case of hypersensitivity to the active ingredient of the drug, in particular, dipyridamole.

Safekeeping

All dosage forms curantyl should be stored in a dry, dark, cool and out of reach of children and pets, in its original packaging, shelf life of tablets, dragees, and ampoules - five years. Unused or expired medication should be disposed of in accordance with the instructions on the packaging or the physician.

Missed dose

If you miss a dose, take it as soon as possible. If you need to quickly take the next dose, forget about the missed reception and follow the established mode of treatment. In no case do not double the dose.

Curantyl Interaction with other drugs

Action chimes weaken xanthine derivatives (eg, coffee, tea), and reinforce - oral indirect anticoagulants (heparin, thrombolytics) or acetylsalicylic acid (increases the risk of hemorrhagic complications). Curantil enhances the hypotensive effect of antihypertensive drugs, weakens the cholinergic properties of cholinesterase inhibitors and enhances antiaggregatory effect with antibiotics-cephalosporins (cefamandole, ceftazidime, tsefotetan).

Additional information about Curantylum

Inside chimes recommended to be taken with food to avoid irritation. Coffee and tea weaken the effect Glockenspiel. Synonyms: dipyridamole, dipiridamin. Absorbability: 70%. Curantil rapidly absorbed from the stomach (most) and small intestine (a small amount). Almost completely bound to plasma proteins (99%). It accumulates primarily in the heart and erythrocytes. It is metabolized by the liver by binding to glucuronic acid, is excreted in the bile of monoglukuronida.

Application curantyl during pregnancy and lactation is possible only after the evaluation of potential risks and expected benefits. Children under the age of twelve years is not recommended to take chimes. Curantil can cause a decrease in blood pressure, which arises as a result of the lack of blood supply to the brain can affect the ability to drive and operate potentially dangerous machinery.