Curantil - a drug that dilates coronary vessels, increases coronary blood flow volume rate, improves myocardial oxygen supply and increases its tolerance to hypoxia.
Indications
Basically chimes is used in combination with anticoagulants, such as warfarin
Warfarin - indirect anticoagulants
For the prevention of postoperative thrombosis (thrombosis can cause strokes, heart attacks and pulmonary embolism) as well as myocardial infarction, cerebrovascular disorders. Curantil belongs to a class antiagregatsionnyh (preventing platelets from sticking together) means (antiplatelet agents). The mechanism of action of vasodilator curantyl plays an important role strengthening the formation of adenosine, one of the participants of autoregulation of the coronary blood flow (flow rate regulation of the heart blood vessels it).
In addition, under the influence of curantyl improved rheological parameters (characteristics of the physical condition of the blood) and kidney function in patients with chronic glomerulonephritis
Glomerulonephritis - a severe infection of the kidneys
. Curantil also acts on arachidonic acid metabolism and increases production of prostacyclin in the vessel walls.
By antiplatelet activity chimes inferior ticlopidine, similar to acetylsalicylic acid. However, it is better tolerated than aspirin, has no ulcerogenic (causing stomach ulcers) action.
Before applying curantyl should always consult with a physician. Use the medication only to treat diseases and conditions specified in the instructions to him or prescribed by a doctor. Curantil can also be used as a preventive measure to reduce the risk of stroke in patients with high risk of blood clots, such as patients undergoing mini stroke (transient ischemic attack), stroke, myocardial (heart attack) or heart surgery.
Contraindications
- widespread atherosclerosis of the coronary arteries;
- acute myocardial infarction;
- decompensated heart failure;
- arrhythmia;
- hypotension;
- renal insufficiency;
- pregnancy;
- Hypersensitivity to Curantylum.
Mode of application
Curantil taken orally as an antithrombotic agent on 0, 025 g (25 mg) four times a day or in accordance with prescribed. As a means to treat angina
Treatment of angina - a versatile approach
Curantylum taken internally (fasting for 1 hour before a meal, but an upset stomach can be taken with food) for 0, 025-0, 05 g (1-2 tablets at 0, 025 g) three times a day. The dosage is determined by the disease, the individual patient and the response to therapy. The course of treatment lasts from several weeks to several months. Do not stop taking the drug after the appearance of favorable results, without consulting a doctor.
Side effects
Nausea, upset stomach, vomiting, headache, tachycardia
Tachycardia - the body to the limit?
, Diarrhea, drop in blood pressure, general weakness are rare, mainly in the initial phase of therapy when the body adapts to the drug. If any of these side effects over time does not disappear, but only intensifies, be sure to consult a doctor. However, in most cases, it chimes well tolerated. In some cases, there are also short-term reddening of the face (vasodilator effect), increased heart rate, and allergic skin rashes. On the part of the cardiovascular system are also marked: palpitations, tachycardia, bradycardia, flushing, coronary steal syndrome, lower blood pressure, anemia, changes in the functional properties of platelets, bleeding, increased bleeding. When these symptoms as soon as possible to see a doctor.
Safety measures
Before taking, tell your doctor about curantyl are hypersensitive (if any), and allergies, as well as heart disease that you are suffering (eg, coronary heart disease, a recent heart attack), as well as lower blood pressure and liver failure
. If you have coronary steal syndrome to improve intracardiac blood flow shows the assignment of aminophylline
. Violation of the liver and biliary tract obstruction necessitate dose reduction
. In addition, the drug can cause dizziness and loss of coordination of movements, so after taking the drug is prohibited to drive vehicles and other complex mechanisms, as well as engage in any activity that requires attention and concentration
. During treatment Curantylum strongly recommended to limit the consumption of alcohol
. If you have an operation (including dental), inform the surgeon that take Curantylum
. Use of the drug during pregnancy, especially during the second and third trimesters may in cases of extreme necessity
. Also, the drug is transferred to the baby through breast milk, so breastfeeding it is not recommended
. To reduce diarrheal events take chimes with milk
. In the treatment should avoid natural coffee and tea reduces the effect of the drug
. For parenteral administration, should not be allowed to enter the drug under the skin (irritative effect possible)
. You can not be administered intravenously at prekollaptoidnom condition and collapse
. Daily doses may be reduced in elderly patients, and while receiving with acetylsalicylic acid
.
Interaction with other drugs
The solution of the drug can not be mixed in the same syringe with other drugs (possibly precipitation). Curantil incompatible with products containing caffeine, xanthine derivatives, which reduce its effectiveness. At simultaneous reception with anticoagulants, aspirin, penicillin antibiotics, cephalosporins, tetracycline, chloramphenicol curantyl antiplatelet effect is enhanced. Simultaneous reception curantyl with cholinesterase inhibitors may lead to a deterioration of the disease in patients with myasthenia gravis.
Overdose
With rapid intravenous possible transient reduction in blood pressure. In case of overdose may intensify the side effects of the drug. Treatment - introduction of vasopressor agents.
Cautions
Do not share your medication with others. If long-term treatment are regularly conducted laboratory and medical tests to monitor the patient's condition and identify side effects.
Missed dose
If you miss a dose, take it as soon as possible. If you need to quickly take the next dose, forget about the missed reception and follow the established mode of treatment. In no case do not double the dose.
Safekeeping
Store in a cool, dry, protected from light and the reach of children and pets at room temperature (25ºC). Permitted short-term storage at a temperature of 15-30ºC). Do not store medication in the bathroom. Do not flush unused product or its residues in the toilet or sink. Shelf life - 1 year 6 months. After expiry dispose of the drug according to instructions.
