Trental is a drug that enhances the permeability of the blood vessels, which leads to improvement of the blood circulation system in general. When the load on the heart does not increase and this is a major advantage trentala.

Trental and pentoxifylline - are one and the same?

Pentoxifylline is active ingredient of many drugs, including trental - such trade name given pentoxifylline pharmaceutical company Aventis Pharma (India).

These drugs are absolutely identical. They mainly promote the charging of additional energy in form of ATP smooth muscle cells of blood vessel walls, and some blood cells - red blood cells and platelets. All this leads to dilation of blood vessels, their terrain (probably a reduction in blood pressure), better saturation of hemoglobin of red blood cells with oxygen and prevents the adhesion of platelets (prevention of thrombosis). As a result of the circulatory system begins to operate more efficiently, but the load on the heart is not increased.

Such action trental allows its wide use in the treatment of many diseases, which are accompanied by poor permeability of blood vessels.

Which diseases apply trental

Trental is prescribed for various diseases that have developed against the background of atherosclerosis Atherosclerosis - a chronic disease of the arteries   and are accompanied by poor permeability of blood vessels. This may be a coronary heart disease Heart disease and heart attacks: that every woman should know   (CHD), stroke, poor circulation in the peripheral blood vessels and so on. In all these cases trental can significantly improve the health of patients.

Vascular disorders typical for diabetes. The most common blood disorders in diabetes Diabetes - threatening and incurable disease   occur in the choroid, retina, peripheral blood vessels of hands and feet. In all these cases appointed trental.

One of the serious diseases that affect mainly young men, is occlusive disease. Today it is considered that this disease is caused by an autoimmune process that is allergic to its own tissues. Under the influence of these processes begin the inflammatory process in walls of blood vessels in the lower limbs. The process is greatly enhanced by smoking and alcohol abuse.

As a result of inflammation of the inner membrane thickening of blood vessels, which greatly reduces their clearance. In addition, inflammation of the membrane covering and other vessels, as well as their surrounding adipose tissue, which condenses and compresses the blood vessels, further enhancing their obstruction. Occlusive disease most often occurs with long slow increase of symptoms. Trental can significantly slow the progression of the disease.

Apply trental well as hearing impairment of vascular origin (hearing loss), venous ulcers, post-thrombotic syndrome and so on.

Can I take Trental without prescription

Trental is usually well tolerated, but it does have contraindications and side effects, which do not allow the use of this medication without a doctor's prescription.

Application trental contraindicated in acute myocardial infarction, the expressed atherosclerotic lesions of blood vessels (including in combination with high blood pressure), any bleeding, including internal (bleeding in the brain, in the retina, and so on) - in all these states trental application can cause considerable harm to the body of the patient.

In addition, trental contraindicated in pregnancy (clinical trials in pregnant women were not conducted), feeding baby Breastfeeding - a personal choice   feeding (trental excreted in mother's milk), and increased sensitivity to trentalu and other xanthine derivatives (caffeine, theophylline, theobromine).

Be wary appoint trental under the age of 18 years (adequate clinical trials with this group of patients have not been conducted), gastric ulcer and duodenal ulcer (tablets), low blood pressure, disorders of the liver and kidneys.

Despite the fact that Trentalum generally well tolerated, and it has a number of side effects (central nervous and cardiovascular system, gastrointestinal tract, blood, organs of vision, allergic reactions) which allows for the doctor when assigning the drug.

When properly administered trental - is an effective drug, but if you take it without all the indications and contraindications, it can cause damage to the body of the patient.

Galina Romanenko

Trental - a drug, which improves blood flow in small blood vessels. It also prevents platelets from sticking together and reduces the viscosity of the blood, which is the prevention of thrombosis. It is used in disorders of blood circulation caused by different reasons.

The mechanism of action trental

Trental (INN - pentoxifylline) - lekarstrennoe is a means of improving blood circulation. Releases trental Indian pharmaceutical company Aventis Pharma tablets, coated tablets, for oral administration of 100 mg in ampoules in a concentrated solution for solution for infusion 5 ml, in tablets for oral administration called trental - 400 400 mg.

Trental has many analogues, various pharmaceutical firms pentoxifylline sold under the name: agapurin, agapurin retard arbifleks, atsupentat, flowerpots, dartelin, kinetal, mellinorm, pentamon, pentilin, pentilin fort pentogeksal, pentoxy, pentoxifylline, pentoxifylline Rivo, pentoxifylline-ICN, Acre pentoxifylline, pentoxifylline, Darnitsa, pentoxifylline-MIC, pentoxifylline-ratiopharm, Teva, pentoxifylline, pentoxifylline-farkos, pentoxifylline-PVD pentomer, Radomin, ralofekt, trenpental, trental, Trental 400 fleksital.

Trentala mechanism of action is based on the fact that it improves the energy potential of the smooth muscle cells of blood vessel walls and blood cells (erythrocytes and platelets) .  This leads to expansion of the small blood vessels, reducing the total peripheral resistance (TPR), an increase in stroke volume and cardiac output without significantly altering the heart rate (HR) .  As a result, improve blood circulation reduces its viscosity, the tendency of platelets to stick together (aggregation) and the formation of blood clots, increased elasticity of erythrocytes .  As a result of the mechanism of action expands the small blood vessels, red blood cells carry more oxygen to the tissues .  If trental administered intravenously, it contributes to the development of collateral (bypassing the main blood vessel) circulation, which is important in diseases such as cerebrovascular disease and ischemic stroke, coronary heart disease, arterial occlusive disease (obstruction of the arteries) and so on .

Indications and contraindications for use

Indications for use trental are:

• cerebrovascular accidents on the background of atherosclerosis, including ischemic stroke;
• peripheral circulatory disorders in the background of atherosclerosis, diabetes (diabetic angiopathy), inflammation;
• peripheral circulatory disorders related to the violation of their innervation (eg, Raynaud's disease);
• trophic disorders of tissues (tissue malnutrition) associated with the defeat of the arteries, veins, or in violation of the circulation in the capillaries (trophic ulcers, gangrene, frostbite);
• circulatory disorders of view - in the retina and choroid;
• disorders of the inner ear vascular origin associated with impaired hearing;
• chronic lung disease, promote blood circulation in the small circle - obstructive bronchitis, bronchial asthma, emphysema;
• sexual dysfunction of vascular origin.

Contraindications trental are:

• myocardial infarction;
• porphyria - an inherited disorder of pigment metabolism, manifested intolerance to light, anemia, gastrointestinal and neuropsychiatric disorders;
• severe bleeding, including internal (hemorrhagic stroke, bleeding in the retina of the eye, and so on);
• pregnancy, breast-feeding Breastfeeding - a personal choice   breast;
• idiosyncrasy trental and other xanthine derivatives (caffeine, theophylline, theobromine);
• intravenous administration is contraindicated cardiac arrhythmias, marked atherosclerosis of the coronary or cerebral arteries, lower blood pressure.

C care to apply trental low blood pressure, congestive heart failure, gastric ulcer and duodenal ulcer (in tablets) directly after previous surgical interventions, in hepatic and renal failure (to be revised dosage), at the age of 18 years.

Trental may increase the effects of blood pressure lowering drugs. On the background of intravenous administration in high doses may enhance insulin action The principles of action of insulin - the science of saving lives   in patients with diabetes.

Side effects trental

Trental is usually well tolerated, but there are side effects:

• the central nervous system - headache, dizziness, insomnia or drowsiness, feeling of anxiety, convulsive readiness;
• from the gastrointestinal tract - dry mouth, loss of appetite, decreased motor activity of the bowel and constipation, cholecystitis exacerbation of hepatitis Hepatitis - the scourge of our time   against the backdrop of stagnation of bile with impaired liver function;
• by the organs of vision - blurred vision;
• from circulation - palpitations, irregular heartbeat, heart pain Pain in the heart - always consult a doctor , Lowering blood pressure, increased frequency of angina attacks;
• from the blood - decrease in the number of platelets, white blood cells, sometimes - all blood cells; violation of blood clotting, and bleeding;
• Other side effects - redness of the face in the form of a "tide", edema, brittle nails;
• allergic reactions.

Trental - a drug that has to appoint a doctor.

Galina Romanenko