Furagin: antimicrobial agent - Mechanism of Action

The mechanism of action furagin

Furagin (INN - furazidin) - is an antimicrobial agent from the group of nitrofurans. Such nitrofurans as furadonin Furadonin - protects the kidneys and urinary tract   and furagin particularly effective in urinary tract infections. They are used to treat other infections. Recently, with the emergence of a large number of new antibiotic nitrofurans are used much less frequently. But they are indispensable in the case where develop resistance to antibiotics. Furthermore, nitrofurans may be used together with antibiotics in mixed species infection.

The mechanism of action is inhibition of furagin biochemical processes that make up the metabolism Improves metabolism and losing weight without dieting   microbial cells, which leads to the destruction of their shell and death.

Furagin active against streptococci, staphylococci, E. coli, Salmonella, bacterial pathogens of dysentery. In addition, it inhibits the ability to live protozoa, such as Giardia.

Large doses nitrofurans, including furagin cause destruction of pathogens, lower - suspension of their life (the bacteria secrete toxins less, which leads to improvement in the overall condition of the patient prior to the complete suppression of growth of pathogens). Nitrofurans favorably with antibiotics that activate the immune system of the body (under the action furagin increased number of leukocytes and their ability to absorb microorganisms) while antibiotics it largely suppressed.

Nitrofuranam resistance, including the furagin develops slowly and does not reach a high degree.

Furagin ingestion is absorbed mainly in the final section of the small intestine into the blood, and stored there for three to eight hours. The urine drug begins to stand out in just three hours after ingestion. He lingers long in the lymph, thereby preventing the spread of infection through the lymphatic vessels. Decomposed furagin slightly, excreted through the kidneys.

Indications and contraindications for receiving furagin

Furagin used in the treatment of the following infections caused by susceptible to the microorganism:

• infections of the kidneys and urinary tract infections - acute and chronic inflammatory diseases of the kidneys (pyelonephritis), bladder Urinary bladder - structure and function   (cystitis), urethra (urethritis);
• Infections of female genital mutilation;
• skin infections (including purulent wounds) and soft tissues;
• deep burns, complicated by infection;
• for the treatment of purulent diseases of the eye - conjunctivitis, keratitis;
• to prevent infections of the kidneys and urinary tract in operations and manipulation tools in this area.

Admission furagin contraindicated:

• with severe renal impairment;
• Pregnancy and breast-feeding Breast-feeding: feed - and no nails!   Child;
• in children up to three years;
• hypersensitivity to nitrofuranam.

Side effects that may occur when using furagin

In applying furagin, like other nitrofurans, may experience the following side effects:

• on the part of the gastrointestinal tract - poor appetite, nausea, vomiting;
• from the liver - a transient dysfunction;
• of the central and peripheral nervous system - headache, dizziness, peripheral nerve;
• Allergic reaction - skin rash, itching, angioedema.

When receiving furagin along with some antibiotics (for example, ristomycin), and sulfonamides may appear side effects such as depression of blood formation, so you should not use them at the same time.

It does not also, along with furaginom used drugs that can acidify the urine (eg, ascorbic acid).

In order to reduce the side effects from taking furagin it recommended to drink it more fluid. If side effects are expressed significantly, it is recommended to stop receiving furagin. Increase the side effects and reception with furaginom alcohol. In order to avoid the danger of peripheral nerves, together furaginom recommended to take B vitamins

Furagin - good antimicrobial drug, which is now increasingly used as a reserve antimicrobial agent in the case, if antibiotics cease to apply.

Galina Romanenko