Ampioks - a drug that combines antimicrobial action ampicillin and oxacillin; It is active against both Gram-positive (Staphylococcus aureus, streptococcus, pneumococcus) and Gram (gonococcus, meningococcus, E. coli, bacillus Pfeiffer influenza bacillus, salmonella Salmonella: unknown facts , Shigella) microorganisms. Thanks to the oxacillin effective against penitsilinazoobrazuyuschih (penicillinase forming - an enzyme that destroys penicillin) staphylococci. Ampioks well into the blood when administered and parenteral (bypassing the digestive tract) administration.

Indications

Ampioks apply in the following cases:

• infectious diseases of the respiratory tract and lungs (bronchitis, pneumonia);
• with angina;
• when cholangitis (inflammation of the bile duct);
• cholecystitis (inflammation of the gallbladder);
• when pyelitis (inflammation of the renal pelvis);
• pyelonephritis Pyelonephritis - kidney disease   (inflammation of the kidney tissue and renal pelvis);
• cystitis (inflammation of the bladder);
• when infected wounds, skin infections;
• when unidentified antibiotikogramme (spectrum activity of the antibiotic Antibiotics - whether they will help you in the foreseeable future? Characterizing the sensitivity to pathogens) and unallocated exciter;
• a mixed infection caused by sensitive and insensitive to benzylpenicillin staphylococcus or streptococcus and Gram negative bacteria;
• in burn disease;
• infections of the kidneys.

Especially shown ampioks in severe cases of the following diseases:

• septicemia (blood poisoning microbes from home purulent inflammation);
• endocarditis (inflammation of the inner cavities of the heart);
• postpartum infection.

The drug is also used to prevent purulent post-operative complications in surgical operations and for the prevention and treatment of infections in neonates.

Side effect

Side effects ampioksa individual; the following side effects are observed not in all cases:

• tenderness at the injection site, and allergic reactions, in rare cases - anaphylactic shock (for parenteral administration ampioksa);
• nausea, vomiting, diarrhea, allergic reactions (when taking into ampioksa).

If necessary, designate desensitizing (warning or braking allergic reactions) funds.

Contraindications

Ampioks contraindicated in toxic-allergic reactions Allergic reactions: how to understand why you tickle in the throat   on the preparations of penicillin.

Dosage

Before the appointment of the drug is recommended to determine sensitivity to the hair that caused the disease in a patient. Newborns, premature infants and children under 1 year administered in a daily dose of 100-200 mg per 1 kg of body weight; children from 1 year to 7 years - 100 mg / kg per day; Children from 7 to 14 years - 50 mg / kg per day; children over the age of 14 years are designated adult dose. In severe infections the dose may be increased to 1, 5-2 times. The duration of treatment is from 5-7 days to 3 weeks or more.

Safekeeping

Keep ampioks should be at room temperature in a dry, dark place, away from children and pets.

The combination of any drug with alcohol, which has a significant effect on the metabolism Metabolism: The basis of life of all living things   and on the central nervous system is undesirable, since the effectiveness of treatment is always reduced. Is no exception and ampicillin, which also has a number of side effects that increase the negative effects of alcohol.

Blow to the liver

Ampicillin may have a negative effect on the liver, causing a violation of its functions stagnation of bile in the biliary tract and cholestatic (bile stasis in the background) jaundice. But this side effect seen in some patients, while most patients tolerate ampicillin without whatsoever disorders of the liver. Why is this happening? It is obvious that those patients who have side effects of ampicillin by the liver, the organ has some possibly very minor changes that do not appear in the form of the disease, but are felt when taking substances that have toxic effects on liver.

Alcohol has a direct toxic effect on the liver cells - it kills them, and in their place grow connective tissue cells. That is formed cirrhosis with slow but irreparable decline in the function of this organ.

If the liver from any minor congenital changes affect two concurrent hepatotoxic agents, the consequences can be very different, for example, in the form of minor liver dysfunction, transient jaundice or toxic hepatitis Toxic hepatitis - the impact of harmful substances on the liver Which is often the cause of death of patients.

The action on the stomach and intestine

Side effect of ampicillin on the gastro-intestinal tract is also evident, not all patients, most of them suffer ampicillin very well. But some patients while taking ampicillin appear nausea, vomiting and diarrhea, which usually does not require discontinuation of the drug and tested independently. The use of alcohol, which irritates the mucous membranes of the gastrointestinal tract, only exacerbate these symptoms and make the drug unbearable.

But the main danger to the gastrointestinal tract while taking ampicillin and alcohol is that both of these substances help to reduce blood clotting. In chronic gastritis, gastroduodenitis and enterocolitis inflammation of the mucosa of the stomach and intestines prone to ulceration and reducing blood clotting increases the risk of internal bleeding. Of course, a healthy person will not be such complications, but if there are any violations of the gastrointestinal tract (especially from unscreened patients), it is better not to risk it.

Strengthening of allergic reactions

All the antibiotics penicillin group often cause allergic reactions. Including a variety allergic reaction may cause and ampicillin. It may be a small rash on the skin, rapidly spreading and merging hives, swelling of turning into the subcutaneous tissue in the throat (angioedema) and causing respiratory failure, anaphylactic shock, a sharp decrease in blood pressure Blood pressure - dangerous if his swing?   and loss of consciousness, Stevens-Johnson syndrome, when vast areas of the skin and mucous membranes become a bleeding ulcer. If the patient takes ampicillin, then he may well develop one of these allergic reactions.

Alcohol itself does not cause allergies, but in alcoholic beverages often contain various impurities, which may well cause allergic reactions. Moreover, alcohol can significantly affect the metabolism Improves metabolism and losing weight without dieting That may cause blood to enter the allergens amplifying any other allergic reaction.

The simultaneous use of ampicillin and alcohol can magnify the risk of severe allergic reactions.

The impact on the treatment of the underlying disease

Ampicillin prescribed for the treatment of infectious and inflammatory diseases. If the drink alcohol, it will break the body's metabolism, thus reducing the effect of the drug ampicillin. Therefore, it is obvious that you need to make a choice between treating a disease ampicillin and alcohol. From their joint application to the patient better not be.

Alcohol is not compatible with any drugs. In this respect, ampicillin is not the most dangerous tool, however, use of alcohol during the course of treatment with ampicillin can backfire.

Galina Romanenko