- Pituitary adenoma - a benign tumor dangerous
- Diagnostics
- Treatment
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Diagnosis of pituitary adenomas
Pituitary adenoma - a benign tumor of glandular tissue, which is located in the anterior pituitary. Why begin the development of this tumor studied enough, some believe that the primary changes occur in the hypothalamus, and then formed under their influence pituitary adenoma.
Well-known factors that contribute to this process, an infectious disease that affects the nervous system, head injuries, adverse factors acting on the fetus during pregnancy, hormonal changes, including long-term use of hormonal contraceptives.
All pituitary adenoma divided into hormonally active (they produce hormones) and hormonally inactive (not produce hormones, but they can compress the surrounding tissue). The size of pituitary adenoma divided into small (1 cm in diameter) and large (more than 1 cm in diameter).
Symptoms of pituitary adenomas
Manifestations pituitary adenoma depend on whether the hormone producing cells adenomas and adenomas of its growth rate. So, adenoma producing prolactin (a hormone that promotes the development of breast milk) is shown the increase in mammary glands, the release of these milk and menstrual irregularities. This adenoma is found most often grows slowly and sometimes does not manifest.
Adenoma, secreting growth hormone, seen rapid growth in childhood (gigantism) or acromegaly (overgrowth of bones and soft tissue), which is observed in tumors in adults.
When adenoma producing adrenocorticotropic hormone (increased production of adrenal hormones) showing signs of the disease Cushing's weakness, fatigue and constantly in a bad mood (depression), swelling, weakening of the heart, high blood pressure, obesity, the body and the face, combined with atrophy (desiccation) of the limbs. Do women have hirsutism (male pattern of body hair). This tumor grows slowly, but more often than other adenomas goes into a malignant tumor.
Adenoma, produces hormones that stimulate the thyroid, occurs more often in patients with a deficiency of thyroid function. Thus there is an excess of thyroid hormone, which is manifested by weight loss, palpitations, irritability
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.
The appearance of adenomas, which produces hormones that regulate gonadal function in men causes of impotence
Impotence - a female perspective on the problem
and the emergence of female sexual characteristics (such as breast growth) in women - menstrual cycle, uterine bleeding and infertility.
As the adenoma it can compress the surrounding tissue, causing a variety of symptoms from the central nervous system, such as blurred vision, even blindness.
Diagnostic tests
In the diagnosis of pituitary adenomas accounted features of its manifestations, be sure to investigate the blood on hormones, giving a basic understanding of what could cause disease. Radioimmunoassay serum to determine the amount of the pituitary hormones in the blood serum.
Additionally, using radiographic (X-ray of the skull, computer and magnetic resonance imaging) methods.
The grounds for suspicion of pituitary adenoma may be available to the patient's symptoms, its history, and the results of various diagnostic procedures.
Description of symptoms is of great importance for the diagnosis, since it gives the doctor information on the basis of which it can decide what methods should be used for further examination.
During diagnostics necessarily do a blood test, however, as the hormones produced by the pituitary gland is not constant, and at certain time intervals, this may be insufficient to evaluate the function of the pituitary gland, and determine which hormone is produced in insufficient or too much. Therefore, the diagnosis also conducted the following tests:
The patient is administered adrenocorticotropic hormone (ACTH), which stimulates the adrenal glands, and 60 minutes later checked cortisol levels. When the pituitary adenoma violates production of ACTH, the adrenal glands lose their ability to produce cortisol in response to stimulation.
This test is also used to determine how pituitary adenoma effect on the production of ACTH. Before bedtime
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the patient is given 12 tablets (3 g), metyrapone, and in the morning take a blood sample to ACTH.
Since metyrapone blocks the production of adrenal hormones, healthy body reacts to this large number of secretion of ACTH. If the level of ACTH in the morning will not be increased, this indicates that the pituitary adenoma has influenced you the production of this hormone.
In this test the patient to lower blood sugar
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Administered insulin. The normal reaction to this is the secretion of ACTH and growth hormone. In patients with growth hormone deficiency and ACTH caused by a pituitary adenoma, this reaction is not observed.
Tests for hormone levels to help confirm the presence of functional adenomas, and take it to Nome or type. Some functional pituitary adenomas, such as prolactinomas, can be successfully treated without surgery, so it is important to analyze hormones before choosing a treatment.
Medical imaging in the diagnosis of pituitary adenoma
At the moment the diagnosis of pituitary adenoma commonly used method such as magnetic resonance imaging (MRI). Using MRI can detect an adenoma with a diameter greater than 4 mm. The most powerful magnetic resonance scanners can "see" even smaller adenomas. Although MRI is the preferred tool for the diagnosis of pituitary adenoma, is sometimes used computed tomography (CT).
Some other tumors cause symptoms similar to the symptoms of pituitary adenoma - they must be excluded during the diagnosis. Such tumors include:
- Craniopharyngiomas;
- Rathke's pouch cyst;
- Meningioma;
- Arachnoid cysts;
- Granulomatous disease;
- Metastatic tumors;
- Chordoma.