Like all other antihistamines drugs diazolin has a number of contraindications. Nevertheless, it is considered the safest drug that in some cases (and only on prescription) take even pregnant women.
Diazolin - how it works
Diazolin is antigistaminnymy drugs that inhibit the action of histamine. Histamine - a neurotransmitter (a substance through which nerve impulses are transmitted), cause an allergic reaction. Cause an allergic reaction and other biologically active substances, but histamine is a fundamental one.
Under the influence of diazolin reduced permeability of the walls of small blood vessels, reduces tissue swelling and itching that is suspended development of an allergic reaction. Once inside diazolin rapidly absorbed into the blood and distributed in the tissues. Almost does not penetrate it only in the brain and spinal cord.
Side effects that may occur while taking diazolin
Diazolin generally well tolerated and rarely give side effects, however, they are found. He may have side effects on the digestive organs, for example, cause irritation of the mucous membrane of the stomach, so it is administered after a meal. Irritation of the gastric mucosa manifested as loss of appetite, nausea, rarely - vomiting, stomach pains. Furthermore, the reception Diazolinum can cause dry mouth
On the part of the central and peripheral nervous system may cause headaches, dizziness
Dizziness - if the ground is slipping from under his feet
, Crawling sensations on the body (paresthesia), lethargy, sleepiness, decreased performance, shaking limbs.
Very rare side effects such as a reduction in the blood of granular white blood cells (granulocytes) which are actively involved in protecting the body from infection. Sometimes disappear completely granulocytes (agranulocytosis) - a serious complication, leading to a sharp decline in immunity - the person becomes vulnerable to infection.
It occurs (but very rarely), and side effects such as frequent painful urination - dysuria.
Paradoxically, there may be an allergic reaction to diazolin which often manifest themselves in the form of urticaria (rapidly appearing and disappearing as quickly as large rash, blisters merging as from contact with nettles).
Contraindications diazolin
Since diazolin irritate the stomach lining, it is contraindicated in patients with erosive and ulcerative processes in this area: erosive gastritis, gastric ulcer and duodenal ulcer in the acute stage. It is undesirable to take diazolin for any inflammatory diseases of the gastrointestinal tract in the acute stage. It is not necessary to appoint diazolin also when pyloric stenosis - narrowing of the space transition persistent stomach into the duodenum.
Contraindications diazolin is angle-closure glaucoma
Glaucoma - a perspective possible blindness
- A disease that often develops in women after age 30, suffering from hyperopia
Hyperopia - than it is fraught?
. This gives rise to frequent headaches caused by a sudden increase in intraocular pressure, typically in one eye. This happens due to the fact that the angle-closure glaucoma space between the cornea and iris through which liquid withdrawn from the eye, more narrow than normal. Therefore, anything that can cause mydriasis (poor lighting, eye drops, assigned to mydriasis before the test, some drugs, such as Diazolinum) may result in the outflow of liquid ceases, which leads to a sudden increase in intraocular pressure.
Since receiving diazolin may cause side effects such as trembling of the limbs and sometimes the entire body, this drug is not prescribed for epilepsy - it can provoke an attack of cramps. In addition, it should not be given to patients with signs of central nervous system depression.
Diazolin not prescribed for heart rhythm disturbances - in this case it can cause improvement of cardiac conduction pulses that arrhythmia will further failure rate.
It does not take diazolin when individual intolerance, as well as an enlarged prostate.
Diazolin excreted in human milk, therefore it should not be taken during breast-feeding
Breast-feeding: feed - and no nails!
. It also crosses the placental barrier, in connection with which it is administered during pregnancy only if the expected benefit to the mother's body than the potential harm to the fetus. With care (often in smaller doses) administered diazolin for liver and kidney with a violation of their functions.
Cooperation
Diazolin interacts with alcohol and enhances the effect of oppressive central nervous system. Diazolin it is forbidden to be used in conjunction with drugs that irritate the mucous membrane of the gastrointestinal tract. Diazolin compatible with ethanol. Before taking drugs containing diazolin, consult your doctor to determine the appropriate dosage and if necessary, choose another drug.
Side effect
- Anaphylactic shock;
- Angioedema;
- Ataxia;
- Diseases of the blood;
- Blurred vision;
- Bronchospasm;
- Cardiac arrhythmias;
- Convulsions;
- Poor coordination of movements (dyspraxia);
- Depression;
- Drowsiness;
- Dry mouth;
- Excessive sweating;
- Extrapyramidal movement;
- Headache;
- Hypertension (high blood pressure);
- Insomnia;
- Leukopenia;
- Abnormal liver function tests;
- Musculoskeletal disorders;
- Muscle pain;
- Cardiopalmus;
- Photosensitivity;
- Paresthesia;
- Rash;
- Vomiting;
- Constipation;
- Dizziness;
- Agranulocytosis (absence or reduction in the number of granulocytes in the blood);
- Tremor;
- Urination disorders
Symptomatic side effects diazolin quite tolerant, but when they gain may require symptomatic treatment. In connection with numerous side effects diazolin may pose a threat to health; in this case the treatment is stopped immediately.
Dosing and Administration
Diazolin are inside (after eating): adults and children over 10 years prescribed by 50-200 mg 1-2 times a day. The maximum doses: single - 300 mg daily - 600 mg; children 5 to 10 years - 100-200 mg / day, from 2 to 5 years - 50-150 mg / day, up to 2 years - 50-100 mg / day.
Safety measures
Care should be taken when using diazolin against the backdrop of the liver and kidneys (a correction dose and intervals between doses), otherwise there is a risk of coma. Diazolin should be used with caution in patients involved in potentially hazardous activities that require increased attention and psychomotor speed reactions. Diazolin also not recommended in patients with epilepsy.
Toxicity
- Nervousness;
- Irritability;
- Depression;
- Hallucinations;
- Anxiety and worry;
- Convulsions;
- Drowsiness;
- Delirium tremens;
- Tachycardia;
- Violation of spatial orientation;
- Hyperthermia (elevated body temperature)
Storage conditions
Make sure to store in a dry, dark place. Shelf life - 3, 5 years.
