Mildronat - a drug that improves metabolic processes, including energy supply of cells and organs. He has found application in the treatment of various diseases of the heart, brain, visual disturbances, and many other diseases, as well as intense physical and mental stress.

The mechanism of action mildronata

Mildronat (meldonium) produces well-known Baltic pharmaceutical company "Grindeks". It is available in capsules and syrups for oral administration to adults and children and a solution for injection. Mildronat refers to a group of drugs that enhance metabolism Improves metabolism and losing weight without dieting   energy and textiles.

The mechanism of drug action based on that mildronat inhibits activity of certain enzymes, resulting in suspended delivery through cell membranes of long chain fatty acids and thus prevents the accumulation in the cells of toxic oxygenated derivatives of fatty acids. In the context of a lack of oxygen in tissues mildronat restores the balance between oxygen delivery and consumption in the cells, eliminates violations of transportation of ATP (an energy source), while activating other energy source - glycolysis (breakdown of glucose Glucose: The energy source   to produce energy), which is carried out without oxygen consumption.

At high physical stress occurs consuming large amounts of energy in the cells of the healthy organism is a temporary decrease in the content of fatty acids, and as soon as the load reduces, the fatty acids accumulate in the cells again. Mildronat coached cells, forcing them to adapt to the process, resulting in trained cells survive where untrained die, for example, in a lack of oxygen in ischemic heart disease.

Mildronat has the following properties:

• cardioprotective - protects myocardial cells, carrying out distribution of blood flow to ischemic foci in its tissue, slows down the process of necrosis (dying off) myocardial tissue shortens the rehabilitation period after myocardial infarction; heart failure it causes the myocardium to contract more efficiently; increases the tolerance of the myocardium of physical activity, reduces the frequency of angina attacks;
• It protects against damage to brain cells in acute and chronic disorders of cerebral circulation by improving blood circulation in the hearth of circulatory disorders;
• protects the cells in the fundus with compromised circulation and metabolism in the art;
• eliminating the accumulation of toxic products of metabolism in the cells of various organs, protecting them from damage;
• under heavy load it restores the balance between the delivery of oxygen to tissues and cells need it
• increases efficiency, reduces the symptoms of mental and physical fatigue;
• regulates cellular immunity;
• reduces the effects of a hangover (abstitentsii) in alcoholism by eliminating the disorders of the central and autonomic nervous system.

After intake of mildronat enters the blood and tissues, a field which breaks down into metabolites, and in three or six o'clock excreted by the kidneys.

Indications and contraindications for use mildronata

Admission mildronata shows:

• coronary heart disease, including angina during Angina - the consequences of the activity   and rest myocardial infarction;
• in chronic cardiovascular disease;
• pain in the heart on the background of violations of metabolic processes in the heart muscle, including the background of hormonal changes;
• in functional disorders of the cardiovascular system in adolescents;
• acute and chronic cerebral circulatory disorders, including the stroke;
• in disorders of blood circulation in the retina of the eye, bleeding in this area, and retinal vein thrombosis; in lesions of the retina of diabetes mellitus and high blood pressure;
• bronchial asthma and chronic bronchitis - to restore cellular immunity in this field;
• during withdrawal (hangover) against alcoholism;
• to improve mental and physical performance;
• postoperatively to accelerate tissue repair.

Contraindications are mildronata :

• hypersensitivity to the drug;
• organic (in violation of the structure, such as a tumor, the effects of traumatic brain injury) brain lesions with increased intracranial pressure;
• pregnancy and lactation - clinical research on these groups of patients have not been conducted.

Side effects that may occur in the application and overdose mildronata

In applying mildronata may experience the following side effects:

• the part of the circulatory system - heart rate, lower blood pressure;
• the central nervous system - excitation, sleep disturbances Dreams: how to understand our dreams ;
• from the gastrointestinal tract - nausea, vomiting, diarrhea;
• allergies - itchy rash, swelling.

Data on overdose mildronata to producers have been reported.

Mildronat - a safe drug, which helps to improve the flow of many diseases.

Galina Romanenko

Preductal - is an effective and safe drug for the treatment of ischemia (insufficient blood supply to tissues) of the heart muscle, eye and ear. He virtually no side effects, and contraindications for it is only a condition in which patients have not been laid clinical trials.

Why preduktal should be taken only on prescription

Preductal very well tolerated, almost no side effects, and its overdoses have no messages. Why, then, this drug is a prescription drug in pharmacies and taken only on prescription?

The problem is that preduktal prescribed for conditions that can threaten the patient's life or lead to disability. Such diseases include:

• Coronary heart disease, which poses a threat to life if angina Angina - oxygen deficiency   It grows into a myocardial infarction Myocardial infarction - the most formidable diagnosis ;
• vascular disorders of the inner ear, resulting in may occur total or partial loss of hearing or develop severe labirintopatiya with bouts of dizziness, nausea, vomiting, decreased blood pressure on a background of progressive hearing loss (Meniere's disease);
• vascular disorders retina and choroid of the organ of vision, which may threaten the decrease or loss of vision.

Self-treatment of such diseases is absolutely impossible, because there requires knowledge and intuition of the doctor: preduktal usually prescribe individually selected dosage to the individual duration of treatment. In the course of treatment the doctor is sometimes necessary to adjust the dose preductal or cancel it altogether in the case against the background of his admission angina or progression of other diseases continues.

Side effects

Preductal has very few side effects. This is mainly allergic reactions that also occur infrequently. Allergies in the form of various types of itchy skin rashes (including urticaria, sometimes passing into angioedema). To continue receiving preductal when the signs of an allergy is impossible, as in the subsequent admission of an allergic reaction can be much stronger.

In addition, when receiving preductal sometimes appear side effects of the gastrointestinal tract as pain in the upper abdomen, nausea, vomiting and diarrhea.

In some cases, preduktal contraindicated

Preductal contraindicated in case of hypersensitivity to it the body of the patient. Furthermore, preduktal has contraindications and virtually no action associated with it. This severe liver and kidney disease with severe disorders of these organs. Despite the fact that in the laboratory during the animal experiments no adverse effects in this case have been identified, the absence of adequate clinical trials in patients with impaired liver function and kidney function did not allow to assign preduktal these patients.

Application preductal during pregnancy as has been confirmed by clinical tests and is therefore not administered to pregnant women, despite the fact that during laboratory animals adverse effects on the fetus, including teratogenicity (leading to developmental abnormalities) have been identified.

During breastfeeding Breast-feeding: feed - and no nails!   preductal appointment means an interruption of breastfeeding, as is still not established whether this drug is released from human milk, and what impact it has on infants.

Lack of clinical trials is the cause of contraindications for appointment preductal children and adolescents.

How to take

The patient should know that preduktal - a drug for long-term use - change the cellular metabolism Improves metabolism and losing weight without dieting   not so easy. Moreover, he must know that preduktal not remove already begun angina, since it does not have vasodilating action.

How to take preduktal, that is, in what dose, how many times a day and for a time determined by your doctor.

There is a standard course of treatment. Tablets 20 mg preductal take one, two or three times a day with meals. Preductal CF, in which each tablet contains 35 mg, taken on a tablet twice a day. Receiving long.

Preductal - is an effective drug for the treatment of coronary heart disease, hearing and visual impairment in the long flowing cerebrovascular disorders. It gives almost no side effects and have few contraindications. However, preduktal can be taken only on prescription.

Galina Romanenko