Creon children widely used in clinical practice. Digestive disorders occur in children of any age in the pathology of the gastrointestinal tract, liver and biliary tract, and especially in diseases of the pancreas, which are often genetic and innate character.
Creon pancreatic diseases in children
Pancreatic diseases in children are often hereditary and are manifested at an early age. One of these diseases is cystic fibrosis, in which there is loss of exocrine glands, violation of electrolyte metabolism and loss of connective tissue. In cystic fibrosis glands that produce digestive enzymes, including pancreas secrete secret of high viscosity with high contents of protein and certain electrolytes and has reduced enzymatic properties. This viscous secret clogs the ducts of glands, which leads to their expansion and the formation of cysts. May join and inflammation of pancreatic tissue replacement by connective tissue.
For the first time the disease manifests in infancy, sometimes - at an older age. The sooner it appear the first symptoms, the harder it takes and the more serious prognosis. The basic appearance of cystic fibrosis is bowel syndrome, which develops due to the significant decrease in the activity of pancreatic enzymes.
As a result, broken and splitting of the absorption of food ingredients - fats, proteins and carbohydrates. Children quickens chair up to five times a day, stool becomes heavy and greasy, has a grayish color and a fetid smell. Some children, on the contrary, there is a tendency to constipation and feces in the form of small compact pellets (sheep feces) which also has a grayish color. Due to the fact that the blood does not enter the desired quantity of nutrients children suffering from mucoviscidosis behind in physical development is especially significant weight loss.
Sometimes cystic fibrosis appears immediately after birth - in the small intestine, a dense long tube from the primary stool - meconium. It can cause necrosis of the bowel and death of the child.
In some cases, cystic fibrosis child proceeds easily and its first symptoms appear after year. It manifested in the form of a disease of chronic pancreatic insufficiency
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. The child may have permanent diarrhea or alternating diarrhea and constipation, abdominal pain
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Bloating. At the same time changes can also occur in other organs of digestion.
In cystic fibrosis children used kreon 10 000, which is a gelatin capsule, within which are microspheres of diameter not greater than 2 mm. Gelatin capsules are readily soluble in the stomach and the microspheres are mixed food mass. Along with it comes the microspheres into the duodenum, where they dissolve the capsules, enzymes are activated and begin to actively break down the food evenly.
In young children also often develop a violation of motor activity (motility) of the digestive system, which is due to several reasons, including the consequences of perinatal lesions of the central nervous system. Such children food is retained in the gastrointestinal tract, which leads to intoxication and constipation - toxic decomposition products of food re-absorbed in the gastrointestinal tract and enter the bloodstream. This is especially dangerous for people with allergies - all the phenomena of atopic dermatitis in children may increase.
In this case, as prescribed Creon - it helps digest food, and the enzymes that break down proteins, stimulate the motility of the upper gastrointestinal tract.
How to take Creon and its dosage
In cystic fibrosis Creon dose is determined individually, depending on the severity of the disease. The initial dose of Creon for children under 4 years of age is 1,000 lipase units per kilogram of body weight, for children older than 4 years - 500 lipase units per kg of body weight per meal. Subsequently, the dose may be adjusted depending on the results of analysis of feces
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and whether or not it undigested fat (steatorrhea).
Creon is taken orally without chewing the capsule and squeezed it with enough water. This first meal is recommended to take half or a third of a single dose at the beginning of the meal, and the rest - during meals.
Young children who can not swallow the capsule whole, it can be opened and the right amount of microspheres mixed liquid food - it is better to do it in a tablespoon. Store such a mixture can not be - it is taken immediately after preparation.
We should not forget that in cystic fibrosis child loses a lot of liquid with liquid stool, and it must make up for the reception of liquid inside. If the child has contrary, constipation, by applying Creon it may increase, and therefore in this case should drink more liquid.
In other diseases and conditions in children, associated with impaired function of the pancreas, a dose of Creon
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10000 set taking into account the degree of deficiency of digestion and fat content in food.
Creon children should be given only pediatrician.
Galina Romanenko
