Causes of psoriasis is currently not known exactly. And this despite the fact that psoriasis has been known since the time of Hippocrates. This is one of the most common and at the same time the mysterious skin disease. Mystery of psoriasis have tried to solve for centuries. Today over it to reveal remove only the edge of the veil.

The main cause of psoriasis - a genetic predisposition

The primary cause of psoriasis today universally recognized genetic predisposition. In a family where one parent suffers from psoriasis, the likelihood of developing the disease in children increases dramatically.

It identified several genes involved in the development of psoriasis, which are called psoriasis susceptibility genes. These genes affect the metabolic processes in the body, control the operation of immunity, including those involved in the development of autoimmune diseases.

And yet, not all people with psoriasis genes, the disease develops. Why is that? It is believed that one of heredity is not enough, you also need triggers.

Immunocompromised

It was found that the active participation in the development of psoriasis takes the immune system. The skin of psoriasis patients have hypersensitivity and hyperreactivity. As a result, mechanical, physical or chemical effects on the skin and shows the characteristic of psoriatic lesions. In the blood of patients showed disruption ratio of immunoglobulins (increases the level of IgG, IgA, IgE level is normal IgM), an antibody in the blood appear to their own skin cells.

In this regard, there is an assumption that the development of the primary focus of psoriatic epidermal damage contributes to an autoimmune process. Inflammation in the skin in psoriasis occurs due to accumulation of T cells, but has not yet understood why activated T lymphocytes in autoimmune processes and the like can be suppressed by this process, without causing serious complications.

Disturbances in metabolism

A significant importance in the development of psoriasis is a metabolic disorder Metabolism: The basis of life of all living things . Under the influence of genetic factors is disturbed protein metabolism - genes encode protein korneodesmosin, the content of which is increased in psoriasis.

But the fundamental importance fat metabolism - in psoriasis always increased lipids and cholesterol in the blood. It was also found that the transition to vegetarian food and malnutrition can reduce and even suppress the exacerbation of psoriatic process. Identified in patients with psoriasis and disorders of carbohydrate metabolism.

Recent studies have revealed a sharp acceleration of metabolic processes in the skin cells in psoriasis. This increases the amount of toxic metabolites (including the free radicals formed as a result of redox reactions), which also contribute to inflammation. This process is enhanced due to a dysfunction of the liver involved in the decomposition of toxic metabolic products into neutral.

Endocrine diseases and foci of infection

Many psoriasis patients are identified endocrine diseases such as diabetes mellitus Diabetes - threatening and incurable disease , Obesity, thyroid dysfunction The thyroid gland - is responsible for your hormones , Hypothalamus, gonads, and so on. Such diseases may play the role of a provoking factor in the development of psoriasis. Nevertheless, the clear association between psoriasis and endocrine diseases to date have not been established.

What matters is the availability of patient foci of infection and chronic infectious-inflammatory processes - they can also trigger the development of exacerbation of psoriasis.

Psychological causes

The nervous system is very important in psoriasis. High stress and emotional stress can trigger the development of an exacerbation of the disease. But sometimes, a lot of stress How to beat stress? Create an oasis   It may be the cause of the disappearance of psoriatic lesions.

Recent studies in this area have made it possible to assume that the strong neuro-psychological experiences can trigger a chain of metabolic and immunological processes leading to the appearance of skin changes.

At the same time, neuropsychiatric disorders as neuroses may be a consequence of a chronic inflammatory process of the skin - all depending on the initial condition of the nervous system of the patient.

Causes of psoriasis today finally installed. The basic causes of the disease and predisposing factors, but have not yet always seen a clear link between them. It is to identify the interaction of all the factors that can cause psoriasis, directed the current research.

Galina Romanenko

The main ingredient in Nizoral shampoo is an antifungal agent ketoconazole. Ketoconazole has the property to kill fungi and yeast microorganisms, affecting their cell membranes. It prevents fungus production of a substance called ergosterol, which is an essential component of fungal cell membranes. Violation generation ergogesterola disturbs the structure of the cell membrane.

Cell membranes are critical for the survival of the fungus, as they hinder the penetration in the cells of various potentially harmful substances. Fungi, which are destroyed by the cell membranes, die quickly and thus, ketoconazole wins infection.

Nizoral is recommended for the treatment of various diseases of the skin caused by a fungus Pitirosporumom, including multi-colored lichen and dandruff, which is considered a mild form of seborrheic dermatitis.

What is dandruff?

Contrary to popular opinion, the cause of dandruff is not dry skin Dry skin: care and treatment   head. This happens, obviously, when dead skin cells begin to peel faster than usual. Normally, the scalp is completely updated in the past month. However, in people suffering from dandruff, this occurs every 10-15 days; when seborrheic dermatitis - even faster. As a result, there are white flakes, which are collected on the hair, neck and clothes; Sometimes this involves a strong itching.

Fungus Pitirosporum which causes occurrence of these symptoms is present in human skin and is almost always a small amount does not cause harm. However, these triggers, such as climate change, the level of hormones and / or stress How to beat stress? Create an oasis   may result in that Pitirosporum begin to accumulate in the scalp. He prefers the skin area, because there is concentrated the largest number of sebaceous glands.

In some cases, seborrheic dermatitis applied to eyebrows, cheeks and breasts.

How to use Nizoral?

Nizoral Apply to wet hair and scalp, a little massage, leave on for 3-5 minutes and then rinse. For the treatment of dandruff Dandruff: where it comes from, and what to do   and seborrheic dermatitis use shampoo twice a week for 2-4 weeks. Once symptoms disappear, to prevent recurrence of infection is sufficient to wash your hair nizoralom once a week or once every two weeks.

To cure pityriasis versicolor Colorful lichen: relapses , Wash your hair nizoralom every day for no more than five days. Relapses of the disease often occur in autumn and summer. To prevent this, use Nizoral every day for three days.

Side effects

Nizoral is a fairly safe drug, it can be used in pregnant or lactating women, but it can have some side effects. For example:

• Burning sensation on the skin
• Itching
• Allergic skin inflammation (contact dermatitis)
• Dry hair
• greasy hair
• Diskoloratsiya hair (rare side effect, usually occurs in people with gray hair or hair damaged by exposure to chemicals)
• Eczema
• Hair loss

Nizoral is not designed for use in conjunction with any other medicated shampoos or ointments. This combination may cause severe irritation to the scalp.

Despite the fact that diskoloratsiya hair using Nizoral rarely observed, it is recommended to first test the shampoo using a small bundle of hair.

Security Nizoral for children under 12 years of age is not confirmed yet, so until this age is not recommended to use it.