Pariet for the treatment of gastritis with high acidity is used widely - he quickly relieves pain, heartburn, diarrhea, and prevents the transition of chronic gastritis in the stomach ulcer. In addition, pariet suppress the livelihoods of the pathogen is Helicobacter pylori, which is often the cause of chronic gastritis.

Chronic gastritis with high acidity - the cause and the main symptoms of the disease

Today, finally it found that the main cause of chronic gastritis is the bacterium Helicobacter pylori, which also causes stomach ulcers and duodenal ulcers. But the pathogen is found in the stomach of many people, with the majority of them do not get sick. What is the reason?

The fact is that the need for the development of the disease predisposing factors. Most often these factors are decreased immunity Immunity - types and characteristics in children in adults , Improper diet and irregular use of substances that irritate the stomach lining (alcohol, strong tea, coffee, hot spices and so on). Under the influence of some of these factors (or more factors), gastric mucosa becomes inflamed and permeable to infection.

The disease occurs in waves: remission alternate with exacerbations. Sometimes, chronic gastritis long asymptomatic. But more often an exacerbation of the disease, pain in the upper abdomen, nausea and sometimes vomiting, heartburn, diarrhea or constipation, bloating.

If the patient does not receive timely medical care, does not observe the diet, chronic gastritis can be complicated by gastric ulcer, stomach bleeding, perforation of the stomach wall, the transition of the inflammatory process in the malignant tumor Malignant tumor: cells are mad .

How to treat chronic gastritis with high acidity

The goal of treatment of chronic gastritis is the elimination of irritating acidic gastric contents in the stomach wall and the destruction of the pathogen Helicobacter pylori. For both purposes pariet approach - a modern drug from the group of proton pump inhibitors (PPIs).

Pariet inhibits secretion of hydrochloric acid by blocking the enzyme H + / K + -ATPase of the parietal cells of the gastric mucosa. Pariet quickly and steadily inhibits the secretion of hydrochloric acid, excelling in this respect, such a popular drug of the same series as omeprazole. The reason is that pariet converted in the body into its active form is much faster than omeprazole.

The advantage of Pariet Pariet: how to cope with gastric ulcer and duodenal ulcer   It is also that it is less dependent on the enzyme system of the liver (Cytochrome P-450). This allows you to fully anticipate the antisecretory action of the drug and reduces the risk of drug interactions (if taken multiple drugs, decomposing in the liver with the help of (cytochrome P-450). The rapid and significant antisecretory action Pariet allow a higher therapeutic efficacy compared with other drugs that line treatment of chronic gastritis with high acidity

Purpose of the drug at 10 or 20 mg per day results in a rapid disappearance of heartburn, stomach pains, nausea, vomiting and diarrhea. Thus there is a significant improvement on the first day of admission. Persistent disappearance of all symptoms of acute gastritis, respectively, achieved after two to four days after the start of treatment.

Helicobacter therapy of chronic gastritis

It was found that pariet has its own antibacterial activity against Helicobacter pylori. Therefore, even if one of his appointing exacerbation of chronic gastritis quickly docked. But to completely remove from the organism Helicobacter pylori Pariet can not, so it can not prevent the recurrence of the disease, and.

Yet pariet used as part of a comprehensive anti-helicobacter terpanes, but not their own, and with antibacterial agents. The treatment regimen includes pariet and two antibacterial drugs (amoxicillin, clarithromycin, metronidazole Metronidazole - what is it?   and others). The course of treatment is usually 7 days, but if necessary, the attending physician can extend it to 14 days.

Pariet enhances the action of antibacterial drugs to reduce their dose, it contributes to the creation in the cells of the gastric mucosa of high concentrations of Pariet. The effectiveness of this combination treatment is 95% or more.

Pariet is well tolerated, both in the short-term treatment of combination treatment and in long-term monotherapy, continuing up to a year. Due to such properties pariet now increasingly used for the treatment of exacerbations of chronic gastritis.

Galina Romanenko

Virtually all known helminth infections can be treated with one of five anthelmintic drugs - albendazole, mebendazole, diethylcarbamazine, ivermectin or praziquantel. Task anthelmintic therapy is to reduce the intensity of the infection; At the same time it is necessary to take measures against the development of resistance to the tablets used for worms.

Infected more than a quarter of the world population

• All the worms that infect man can be divided into three major groups: n nematodes (roundworms, pinworms);
• Trematodes (flatworms);
• Cestodes (tapeworms).

Together, these worms Worms - how dangerous they are?   are the causes of infections more than a quarter of the world's population; the total number of deaths caused by them almost beyond counting. With few exceptions, caused by worms complications depend on the intensity of infection: the more severe the symptoms, the more severe effects of the disease can be. Thus, although ideally should be the result of treatment complete recovery, reducing the intensity of the infection also is a satisfactory outcome.

The drugs recommended by WHO

For the treatment of infections caused by nematodes, the WHO recommends the use of pyrantel Pyrantel: a means to combat intestinal parasites , Levamisole and piperazine, in addition to albendazole and mebendazole. In the treatment of infections caused by a other types of worms Types of worms and the consequences of their occurrence , Recommended metrifonate, oxamniquine and praziquantel.

Useful combinations of drugs

In addition to the monotherapy, in some cases, for the treatment of parasitic infections, you can use a combination of several drugs.

• Cimetidine increases drug concentration

In the combined use of cimetidine and mebendazole mebendazole indicated greater concentration in serum, and more pronounced therapeutic effect than if a single mebendazole. A similar effect was observed in the combined use of cimetidine and albendazole.

• More than one infection

The combined use of praziquantel and benzimidazole eliminates simultaneously from three main types of worms. This combination does not reduce the effectiveness of each of the drugs, and does not increase the likelihood of side effects.

Preparations for worms during pregnancy

Treatment of worms during pregnancy - a fairly common need, which, however, involve some problems. Particularly important operatively treat infections caused by nematodes, since they are associated with an increased risk of iron deficiency anemia Iron deficiency anemia: how dangerous it is? Especially in regions where anemia is a common problem due to dietary habits.

Mebendazole

Although in the experiments on rats it was found that mebendazole is teratogenic in retrospective study 112 pregnant women was found that only one of them, the use of the drug has led to violations of embryonic development. In Sri Lanka, where the anemia during pregnancy is a widespread problem, and nematodes are endemic in many parts of the country, since 1994, all pregnant women after the first trimester of pregnancy prescribe a course of reception of mebendazole. Experience in this country suggests that mebendazole to pregnant women is relatively safe, and if necessary, it can be used to treat worms - at least after the twelfth week.

Albendazole

Since albendazole absorbed active than mebendazole, it is believed that the likelihood of side effects when used above. However, in the study of 10 cases in which pregnant women are randomly taken high doses of albendazole (for the treatment of systemic infections) was not marked teratogenic effects of this drug.

Diethylcarbamazine and ivermectin

Diethylcarbamazine for the past several decades is widely used for the treatment of filariases (a type of helminth infections caused by nematodes). Application ivermiktina began to spread relatively recently, but efficacy has been confirmed many times. While there is no evidence that these drugs are teratogenic. In the experimental mice ivermectin led to the birth of babies with cleft palate, and sometimes the death of pregnant mice for unclear reasons. For rats and rabbits drug was much more secure. Nevertheless, applied ivermectin during pregnancy is not recommended.

Praziquantel

Praziquantel is not teratogenic in animals, but so far no studies that would allow to draw conclusions about its safety for pregnant women who use it during pregnancy should not be.

Comparative efficacy of the five most frequently used anthelmintic drugs to treat various helminthiases.

• ++ High efficiency;
• : + Moderate effectiveness;
• ±: minimum efficiency;
• -: Not effective, or not used to treat the disease;
• (++) Is effective but is associated with severe side effects;
• ? : Not available.