Ersefuril - instructions for use of the drug's manufacturer - the pharmaceutical company Sanofi (France). It details the mechanism of action, indications and contraindications for its use, possible side effects and so on.
The mechanism of action ersefuril
Ersefuril - it is an antibacterial drug broad spectrum to treat infections of the gastrointestinal tract, the active substance of which is nifuroxazide belonging to the group of nitrofurans. Produced ersefuril capsules for oral use, each containing 200 mg nifuroxazide in a 4% suspension in 5 ml which contained 200 mg as nifuroxazide. Nifuroxazide is also the active substance of such drugs as diastat, Enterofuril
Enterofuril - help with the intestinal infection
Auxiliaries ersefuril capsules are corn starch, sucrose and magnesium stearate. The composition of the capsule comprises gelatin, titanium dioxide, dye - yellow iron oxide.
When used in recommended doses ersefuril has a bacteriostatic effect (suppress the livelihoods of pathogens intestinal infections), high doses - bactericidal (kills these pathogens). The mechanism of action associated with suppression ersefuril some redox enzyme reactions in the cells of pathogens.
Sensitivity to ersefurilu
Ersefuril - to cope with a slight diarrhea of infectious origin
shows the majority of microorganisms that cause intestinal infections: Staphylococcus, Streptococcus, Clostridium, E. coli, salmonella
Salmonella: unknown facts
, Shigella, enterobacteria Yersinia and Vibrio cholerae even. Immune to ersefurilu Klebsiella, some strains of Proteus and some other agents of intestinal infections. A feature ersefuril (like all nitrofurans) is that they have not developed resistance (immunity) agents of intestinal infections and inhibits the development of intestinal microflora.
Ersefuril acts only locally in the gut and practically not absorbed into the blood and does not have a general (systemic) action.
Indications and contraindications for use ersefuril
The indications for use are ersefuril diarrhea of infectious origin caused by susceptible pathogens to ersefurilu. Ersefuril it makes sense to apply only in the case where the infectious process occurs without fever or worsening of general condition. Simultaneously with the reception ersefuril need to replenish lost fluids in the form of abundant drinking or saline solutions prepared based drugs (eg, rehydron).
Do not use this ersefuril hypersensitivity to nitrofuran derivatives or any of the excipients of the drug, fructose intolerance, a syndrome of glucose-galactose malabsorption or failure sucrase and isomaltase (due to the presence in the preparation of sucrose) and during pregnancy (no clinical experience with ersefuril in pregnant ). Capsules ersefuril not approved for use in children under six years old, the slurry - children under the age of one month. In some countries, the suspension is not allowed for the use of children under the age of two years.
Breastfeeding is not a contraindication for use ersefuril as a short course of treatment.
Side effects and possible overdose
Ersefuril very well tolerated by both adults and children. Drug overdose is practically impossible, since 99% of it does not get into the blood and has no systemic effects.
But even 1% of the substance has got into the blood enough to cause an allergic reaction. Allergic reactions while taking ersefuril may take the form of various kinds of itchy allergic rash, quickly appearing and disappearing hives (rash of blisters run together), angioedema (angioedema subcutaneous tissue, which can lead to respiratory failure). The most severe allergic reaction to the reception ersefuril may be anaphylactic shock, which is quite rare and is accompanied by a sharp decrease in blood pressure
Blood pressure - dangerous if his swing?
, Collapse and loss sznaniya. If you suspect an allergic reaction ersefuril intake should be discontinued.
Ersefuril - a drug nitrofuran series, which is used for the treatment of mild intestinal infections without disrupting the overall condition of the patient. For treatment of more severe intestinal infections, antibiotics are used, providing general (systemic) action.